Fast mapping of the T2 relaxation time of cerebral metabolites using proton echo-planar spectroscopic imaging (PEPSI)

Magnetic Resonance in Medicine

Volumn 57, Issue 5, 2007, Pages 859-865

  Tsai, Shang Yueh ^a   Posse, Stefan ^b,c   Lin, Yi Ru ^d   Ko, Cheng Wen ^e   Otazo, Ricardo ^c   Chung, Hsiao Wen ^a   Lin, Fa Hsuan ^a,f,g  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c University of New Mexico   (United States)

^d NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cerebral metabolites; Gray white matter difference; Proton echo planar spectroscopic imaging; Single voxel spectroscopy; T 2 relaxation time

Indexed keywords

BIOMOLECULES; CORRELATION METHODS; DATA ACQUISITION; MAPPING; RELAXATION TIME; SIGNAL TO NOISE RATIO;

ACCURATE QUANTIFICATIONS; ACQUISITION TIME; CEREBRAL METABOLITES; ECHO-PLANAR SPECTROSCOPIC IMAGING; GRAY/WHITE MATTER DIFFERENCE; N-ACETYL ASPARTATE; PEARSON'S CORRELATION COEFFICIENTS; SINGLE-VOXEL SPECTROSCOPIES;

METABOLITES;

CHOLINE; CREATININE; N ACETYLASPARTIC ACID; ASPARTIC ACID; CREATINE; DRUG DERIVATIVE; N-ACETYLASPARTATE; PROTON; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BRAIN METABOLISM; CORRELATION COEFFICIENT; ECHO PLANAR IMAGING; FEMALE; GRAY MATTER; HUMAN; MALE; NORMAL HUMAN; RELAXATION TIME; SIGNAL NOISE RATIO; SPECTROSCOPY; WHITE MATTER; BRAIN; BRAIN LEVEL; IMAGE PROCESSING; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ADULT; ASPARTIC ACID; BRAIN; BRAIN CHEMISTRY; CHOLINE; CREATINE; ECHO-PLANAR IMAGING; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PROTONS;

EID: 34248142559     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21225     Document Type: Article

References (34)

1. Brief EE, Whittall KP, Li DK, MacKay AL. Proton T2 relaxation of cerebral metabolites of normal human brain over large TE range. NMR Biomed 2005;18:14-18.
2. Traber F, Block W, Lamerichs R, Gieseke J, Schild HH. 1H metabolite relaxation times at 3.0 Tesla: measurements of T1 and T2 values in normal brain and determination of regional differences in transverse relaxation. J Magn Reson Imaging 2004;19:537-545.
3. Mlynarik V, Gruber S, Moser E. Proton T(1) and T(2) relaxation times of human brain metabolites at 3 Tesla. NMR Biomed 2001;14:325-331.
4. Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hanicke W, Sauter R. Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolites. Magn Reson Med 1989;11:47-63.
5. van der Toorn A, Dijkhuizen RM, Tulleken CA, Nicolay K. T1 and T2 relaxation times of the major 1H-containing metabolites in rat brain after focal ischemia. NMR Biomed 1995;8:245-252.
6. Walker PM, Ben Salem D, Lalande A, Giroud M, Brunotte F. Time course of NAA T2 and ADC(w) in ischaemic stroke patients: 1H MRS imaging and diffusion-weighted MRI. J Neurol Sci 2004;220:23-28.
7. Lei H, Zhang Y, Zhu XH, Chen W. Changes in the proton T2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T. Magn Reson Med 2003;49:979-984.
8. Kamada K, Houkin K, Hida K, Matsuzawa H, Iwasaki Y, Abe H, Nakada T. Localized proton spectroscopy of focal brain pathology in humans: significant effects of edema on spin-spin relaxation time. Magn Reson Med 1994;31:537-540.
9. Isobe T, Matsumura A, Anno I, Yoshizawa T, Nagatomo Y, Itai Y, Nose T. Quantification of cerebral metabolites in glioma patients with proton MR spectroscopy using T2 relaxation time correction. Magn Reson Imaging 2002;20:343-349.
10. Fujimori H, Michaelis T, Wick M, Frahm J. Proton T2 relaxation of cerebral metabolites during transient global ischemia in rat brain. Magn Reson Med 1998;39:647-650.
11. Wilkinson ID, Paley M, Chong WK, Sweeney BJ, Shepherd JK, Kendall BE, Hall-Craggs MA, Harrison MJ. Proton spectroscopy in HIV infection: relaxation times of cerebral metabolites. Magn Reson Imaging 1994;12:951-957.
12. Christensen JD, Kaufman MJ, Frederick B, Rose SL, Moore CM, Lukas SE, Mendelson JH, Cohen BM, Renshaw PF. Proton magnetic resonance spectroscopy of human basal ganglia: response to cocaine administration. Biol Psychiatry 2000;48:685-692.
13. Cady EB. Metabolite concentrations and relaxation in perinatal cerebral hypoxic-ischemic injury. Neurochem Res 1996;21:1043-1052.
14. Rooney WD, Ebisu T, Mancuso A, Graham S, Weiner MW, Maudsley AA. Metabolite 1H relaxation in normal and hyponatremic brain. Magn Reson Med 1996;35:688-696.
15. Sijens PE, Oudkerk M. 1H chemical shift imaging characterization of human brain tumor and edema. Eur Radiol 2002;12:2056-2061.
16. Choi CG, Frahm J. Localized proton MRS of the human hippocampus: metabolite concentrations and relaxation times. Magn Reson Med 1999;41:204-207.
17. Hetherington HP, Mason GF, Pan JW, Ponder SL, Vaughan JT, Twieg DB, Pohost GM. Evaluation of cerebral gray and white matter metabolite differences by spectroscopic imaging at 4.1T. Magn Reson Med 1994;32:565-571.
18. Posse S, Cuenod CA, Risinger R, Le Bihan D, Balaban RS. Anomalous transverse relaxation in 1H spectroscopy in human brain at 4 Tesla. Magn Reson Med 1995;33:246-252.
19. Duyn JH, Moonen CT. Fast proton spectroscopic imaging of human brain using multiple spin-echoes. Magn Reson Med 1993;30:409-414.
20. Mansfield P. Spatial mapping of the chemical shift in NMR. Magn Reson Med 1984;1:370-386.
21. Adalsteinsson E, Irarrazabal P, Topp S, Meyer C, Macovski A, Spielman DM. Volumetric spectroscopic imaging with spiral-based k-space trajectories. Magn Reson Med 1998;39:889-898.
22. Posse S, Dager SR, Richards TL, Yuan C, Ogg R, Artru AA, Muller-Gartner HW, Hayes C. In vivo measurement of regional brain metabolic response to hyperventilation using magnetic resonance: proton echo planar spectroscopic imaging (PEPSI). Magn Reson Med 1997;37:858-865.
23. Posse S, Tedeschi G, Risinger R, Ogg R, Le Bihan D. High speed 1H spectroscopic imaging in human brain by echo planar spatial-spectral encoding. Magn Reson Med 1995;33:34-40.
24. Chu A, Alger JR, Moore GJ, Posse S, Proton echo-planar spectroscopic imaging with highly effective outer volume suppression using combined presaturation and spatially selective echo dephasing. Magn Reson Med 2003;49:817-821.
25. Dager SR, Friedman SD, Heide A, Layton ME, Richards T, Artru A, Strauss W, Hayes C, Posse S. Two-dimensional proton echo-planar spectroscopic imaging of brain metabolic changes during lactate-induced panic. Arch Gen Psychiatry 1999;56:70-77.
26. Dager SR, Layton ME, Strauss W, Richards TL, Heide A, Friedman SD, Artru AA, Hayes CE, Posse S. Human brain metabolic response to caffeine and the effects of tolerance. Am J Psychiatry 1999;156:229-237.
27. Haase A, Frahm J, Hanicke W, Matthaei D. 1H NMR chemical shift selective (CHESS) imaging. Phys Med Biol 1985;30:341-344.
28. Prato FS, Drost DJ, Keys T, Laxon P, Comissiong B, Sestini E. Optimization of signal-to-noise ratio in calculated T1 images derived from two spin-echo images. Magn Reson Med 1986;3:63-75.
29. Bottomley PA. Spatial localization in NMR spectroscopy in vivo. Ann NY Acad Sci 1987;508:333-348.
30. Bendszus M, Warmuth-Metz M, Klein R, Burger R, Schichor C, Tonn JC, Solymosi L. MR spectroscopy in gliomatosis cerebri. AJNR Am J Neuroradiol 2000;21:375-380.
31. Wiggins GC, Triantafyllou C, Potthast A, Reykowski A, Nittka M, Wald LL. 32-Channel 3 Tesla receive-only phased-array head coil with soccer-ball element geometry. Magn Reson Med 2006;56:216-223.
32. Posse S, Otazo R, Caprihan A, Bustillo J, Chen H, Zuo C, Renshaw P, Magnotta V, Mueller B, Lim KO, Ugurbil K, Mullins P, Gasparovic C, Alger JR. Rapid brain glutamate mapping in central and peripheral gray matter at 3 and 4 Tesla using short TE proton-echoplanar-spectroscopic-imaging (PEPSI). In Proceedings of the 14th Annual Meeting of ISMRM; Seattle, USA, 2006. p 484.
33. Posse S, Otazo R, Tsai SY, Wald LL, Lin FH. Sensitivity encoded proton echo planar spectroscopic imaging (PEPSI) in human brain at 7 Tesla. In: Proceedings of the 14th Annual Meeting of ISMRM, Seattle, WA, USA, 2006 (Abstract 3079).
34. Dydak U, Weiger M, Pruessmann KP, Meier D, Boesiger P. Sensitivity-encoded spectroscopic imaging. Magn Reson Med 2001;46:713-722.