Analysis of loss of heterozygosity in single-system and multisystem langerhans' cell histiocytosis

Pediatric and Developmental Pathology

Volumn 10, Issue 1, 2007, Pages 18-24

  Chikwava, Kudakwashe R ^a   Hunt, Jennifer L ^b   Mantha, Geeta S ^a   Murphy, Justin E ^a   Jaffe, Ronald ^c  

^a PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Allelic imbalance; Langerhans' cell histiocytosis; Loss of heterozygosity; Mutations; Tumor suppressor genes

Indexed keywords

DNA;

ADOLESCENT; ALLELE; ARTICLE; CAPILLARY ELECTROPHORESIS; CHILD; CHROMOSOME 5Q; CLINICAL ARTICLE; DISEASE COURSE; DNA EXTRACTION; FEMALE; FISHER EXACT TEST; GENE AMPLIFICATION; GENETIC ANALYSIS; HETEROZYGOSITY LOSS; HIGH RISK PATIENT; HISTIOCYTOSIS X; HUMAN; HUMAN TISSUE; INFANT; MALE; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; TUMOR SUPPRESSOR GENE; GENETIC MARKER; GENETICS; PRESCHOOL CHILD; RETROSPECTIVE STUDY;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; GENES, TUMOR SUPPRESSOR; GENETIC MARKERS; HISTIOCYTOSIS, LANGERHANS-CELL; HUMANS; INFANT; LOSS OF HETEROZYGOSITY; MALE; POLYMERASE CHAIN REACTION; PROGNOSIS; RETROSPECTIVE STUDIES;

EID: 34247899162     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/06-02-0045.1     Document Type: Article

References (15)

1. Shimakage M, Sasagawa T, Kimura M, et al. Expression of Epstein-Barr virus in Langerhans' cell histiocytosis. Hum Pathol 2004;35: 862-868.
2. Glotzbecker MP, Carpentieri DF, Dormans JP. Langerhans cell histiocytosis: a primary viral infection of bone? Human herpes virus 6 latent protein detected in lymphocytes from tissue of children. J Pediatr Orthop 2004;24:123-129.
3. Egeler RM, Favara BE, van Meurs M, Laman JD, Claassen E. Differential in situ cytokine profiles of Langerhans-like cells and T cells in Langerhans cell histiocytosis: abundant expression of cytokines relevant to disease and treatment. Blood 1999;94:4195-4201.
4. Bank MI, Gudbrand C, Rengtved P, et al. Immunohistochemical detection of the apoptosis-related proteins FADD, FLICE and FLIP in Langerhans cell histiocytosis. J Pediatr Hematol Oncol 2005;27:301-306.
5. Willman CL. Detection of clonal histiocytes in Langerhans cell histiocytosis: biology and clinical significance. Br J Cancer Suppl 1994;23:S29-S33.
6. Laman JD, Leenen PJ, Anneis NE, Hogendoorn PC, Egeler RM. Langerhans-cell histiocytosis 'insight into DC biology.' Trends Immunol 2003;24:190-196.
7. Fadeel B, Henter JI. Langerhans-cell histiocytosis: neoplasia or unbridled inflammation? Trends Immunol 2003;24:409-410.
8. Willman CL, Busque L, Griffith BB, et al. Langerhans'-cell histiocytosis (histiocytosis X): a clonal proliferative disease. N Engl J Med 1994;331:154-160.
9. Yu RC, Chu C, Buluwela L, Chu AC. Clonal proliferation of Langerhans cells in Langerhans cell histiocytoses. Lancet 1994;343: 767-768.
10. Murakami I, Gogusev J, Fournet JC, Glorion C, Jaubert F. Detection of molecular cytogenetic aberrations in Langerhans cell histiocytosis of bone. Hum Pathol 2002;33:555-560.
11. Dacic S, Trusky C, Bakker A, Finkelstein SD, Yousem SA. Genotypic analysis of pulmonary Langerhans cell histiocytosis. Hum Pathol 2003;34:1345-1349.
12. Ladisch S, Gadner H, Arico M, et al. LCH-1: a randomized trial of etoposide vs. vinblastine in disseminated Langerhans cell histiocytosis. The Histiocyte Society. Med Pediatr Oncol 1994;23:107-110.
13. Minkov M, Grois N, Heitger A, Potschger U, Westermeier T, Gadner H. Response to initial treatment of multisystem Langerhans cell histiocytosis: an important prognostic indicator. Med Pediatr Oncol 2002;39:581-585.
14. Steiner M, Matthes-Martin S, Attarbaschi A, et al. Improved outcome of treatment-resistant high-risk Langerhans cell histiocytosis after allogeneic stem cell transplantation with reduced-intensity conditioning. Bone Marrow Transplant 2005;36:215-225.
15. Bank MI, Rengtved P, Carstensen H, Petersen BL. p53 expression in biopsies from children with Langerhans cell histiocytosis. J Pediatr Hematol Oncol 2002;24:733-736.