Hypoglycemia due to ectopic release of insulin from a paraganglioma

Hormone Research

Volumn 67, Issue 6, 2007, Pages 292-295

  Uysal, M ^a   Temiz, S ^a   Gul, N ^a   Yarman, S ^a   Tanakol, R ^a   Kapran, Y ^b  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Ectopic insulin secretion; Hyperinsulinemia; Hypoglycemia; Paraganglioma

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CATECHOLAMINE; GLUCOSE; INSULIN; PHENOXYBENZAMINE;

ADRENERGIC SYSTEM; AGED; ARTICLE; CASE REPORT; CATECHOLAMINE BLOOD LEVEL; DIET RESTRICTION; ECTOPIC HORMONE PRODUCTION; FEMALE; HISTOPATHOLOGY; HUMAN; HYPOGLYCEMIA; IMMUNOPHENOTYPING; INSULIN RELEASE; LABORATORY TEST; NEUROENDOCRINE TUMOR; PARAGANGLIOMA; PHYSICAL EXAMINATION; PRIORITY JOURNAL;

AGED; FEMALE; HORMONES, ECTOPIC; HUMANS; HYPOGLYCEMIA; INSULIN; PARAGANGLIOMA; RADIOGRAPHY, ABDOMINAL; RETROPERITONEAL NEOPLASMS;

EID: 34247893843     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000099291     Document Type: Article

References (25)

1. Service FJ: Hypoglycemic disorders. N Engl J Med 1995;332:1144-1152.
2. Koch CA, Rother KI, Roth J: Tumor hypoglycemia linked to IGF-II; in Rosenfeld R, Roberts C Jr (eds): Contemporary Endocrinology: The IGF System. Totowa, Humana Press, 1999, pp 675-698.
3. Daughaday WH, Trivedi B: Measurement of derivatives of proinsulin-like growth factor-II in serum by a radioimmunoassay directed against the E-domain in normal subjects and patients with nonislet cell tumor hypoglycemia. J Clin Endocrinol Metab 1992;75:110-115.
4. Seckl MJ, Mulholland PJ, Bishop AE, Teale JD, Hales CN, Glaser M, Watkins S, Seckl JR: Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix. N Engl J Med 1999;341:733-736.
5. Shames JM, Dhurandhar NR, Blackard WG: Insulin-secreting bronchial carcinoid tumor with widespread metastases. Am J Med 1968;44:632-637.
6. Fujino K, Yamamoto S, Matsumoto M, Sunada M, Ota T: Paraganglioma associated with hypoglycemia. Intern Med 1992;31:1239-1241.
7. Jacobs P, Wood L: Recurrent benign erythropoietin-secreting pheochromocytomas. Am J Med 1994;97:307-308.
8. Landsberg L, Young JB: Catecholamines and the adrenal medulla; in Wilson JD, Foster DW (eds): Williams Textbook of Endocrinology, ed 8. Philadelphia, Saunders, 1992, p 669.
9. Heath H 3rd, Edis AJ: Pheochromocytoma associated with hypercalcemia and ectopic secretion of calcitonin. Ann Intern Med 1979;91:208-210.
10. Manger WM, Gifford RW Jr: Pheochromocytoma: current diagnosis and management. Cleve Clin J Med 1993;60:365-378.
11. O'Brien T, Young WF Jr, Davila DG, Scheithauer BW, Kovacs K, Horvath E, Vale W, van Heerden JA: Cushing's syndrome associated with ectopic production of corticotrophin-releasing hormone, corticotrophin and vasopressin by a phaeochromocytoma. Clin Endocrinol (Oxf) 1992;37:460-467.
12. Sparagana M, Feldman JM, Molnar Z: An unusual pheochromocytoma associated with an androgen secreting adrenocortical adenoma: evaluation of its polypeptide hormone, catecholamine, and enzyme characteristics. Cancer 1987;60:223-231.
13. Sano T, Saito H, Yamasaki R, Hosoi E, Kameyama K, Saito S, Hirose T, Hizawa K: Production and secretion of immunoreactive growth hormone-releasing factor by pheochromocytomas. Cancer 1986;57:1788-1793.
14. Viale G, Dell'Orto P, Moro E, Cozzaglio L, Coggi G: Vasoactive intestinal polypeptide-, somatostatin-, and calcitonin-producing adrenal pheochromocytoma associated with the watery diarrhea (WDHH) syndrome: first case report with immunohistochemical findings. Cancer 1985;55:1099-1106.
15. Mune T, Katakami H, Kato Y, Yasuda K, Matsukura S, Miura K: Production and secretion of parathyroid hormone-related protein in pheochromocytoma: participation of an alpha-adrenergic mechanism. J Clin Endocrinol Metab 1993;76:757-762.
16. Hassoun J, Monges G, Giraud P, Henry JF, Charpin C, Payan H, Toga M: Immunohistochemical study of pheochromocytomas: an investigation of methionine-enkephalin, vasoactive intestinal peptide, somatostatin, corticotropin, beta-endorphin, and calcitonin in 16 tumors. Am J Pathol 1984;114:56-63.
17. Sasaki A, Yumita S, Kimura S, Miura Y, Yoshinaga K: Immunoreactive corticotropin-releasing hormone, growth hormone-releasing hormone, somatostatin, and peptide histidine methionine are present in adrenal pheochromocytomas, but not in extraadrenal pheochromocytoma. J Clin Endocrinol Metab 1990;70:996-999.
18. Hashimoto K, Suemaru S, Hattori T, Sugawara M, Ota Z, Takata S, Hamaya K, Doi K, Chretien M: Multiple endocrine neoplasia with Cushing's syndrome due to paraganglioma producing corticotropin-releasing factor and adrenocorticotropin. Acta Endocrinol (Copenh) 1986;113:189-195.
19. Apple D, Kreines K: Cushing's syndrome due to ectopic ACTH production by a nasal paraganglioma. Am J Med Sci 1982;283:32-35.
20. Lieberum B, Jaspers C, Munzenmaier R: ACTH-producing paraganglioma of the paranasal sinuses. HNO 2003;51:328-331.
21. Kitahara M, Mori T, Seki H, Washizawa K, Amano Y, Nakahata T, Takeuchi S, Inaba H, Hotchi M, Komiyama A: Malignant paraganglioma presenting as Cushing syndrome with virilism in childhood. Production of cortisol, androgens, and adrenocorticotrophic hormone by the tumor. Cancer 1993;72:3340-3345.
22. Park HK, Park CM, Ko KH, Rim MS, Kim YI, Hwang JH, Im SC, Kim YC, Park KO: A case of Cushing's syndrome in ACTH-secreting mediastinal paraganglioma. Korean J Intern Med 2000;15:142-146.
23. Omura M, Sato T, Cho R, Iizuka T, Fujiwara T, Okamoto K, Tashiro Y, Chiba S, Nishikawa T: A patient with malignant paraganglioma that simultaneously produces adrenocorticotropic hormone and interleukin-6. Cancer 1994;74:1634-1639.
24. Linnoila RI, Lack EE, Steinberg SM, Keiser HR: Decreased expression of neuropeptides in malignant paragangliomas: an immunohistochemical study. Hum Pathol 1988;19:41-50.
25. Erickson D, Kudva YC, Ebersold MJ, Thompson GB, Grant CS, van Heerden JA, Young WF Jr: Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab 2001;86:5210-5216.