Genetic polymorphisms in CYP1A1, CYP2D6, UGT1A6, UGT1A7, and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 70, Issue 11, 2007, Pages 916-924

  Gu, Shou Yong ^a   Zhang, Zhong Bin ^a   Wan, Jun Xiang ^a   Jin, Xi Peng ^a   Xia, Zhao Lin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE; CHLOROFORM; CYTOCHROME P450 1A1; CYTOCHROME P450 2D6; GENOMIC DNA; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; PHENOL; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; UNCLASSIFIED DRUG;

ADULT; ALLELE; BENZENE INTOXICATION; BLOOD SAMPLING; CANCER RISK; CARCINOGENESIS; CHINA; CHINESE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA ISOLATION; FEMALE; GENE FUNCTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL TOXICOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUESTIONNAIRE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; ARYLSULFOTRANSFERASE; BENZENE; CASE-CONTROL STUDIES; CHINA; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2D6; DNA FINGERPRINTING; ENZYMES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUCURONOSYLTRANSFERASE; HUMANS; INHALATION EXPOSURE; MALE; MIDDLE AGED; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SOLVENTS;

EID: 34247891534     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390701290139     Document Type: Conference Paper

References (36)

1. Alvan, G., Bechtel, P., Iselius, L., and Gundert-Remy, U. 1990. Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations. Eur. J. Clin. Pharmacol. 39:533-537.
2. Anwar, W. A., Abdel-Rahman, S. Z., El-Zein, R. A., Mostafa, H. M., and Au, W. W. 1996. Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients. Carcinogenesis 17:1923-1929.
3. Caporaso, N., Hayes, R. B., Dosemeci, M., Hoover, R., Ayesh, R., Hetzel, M., and Idle, J. 1989. Lung cancer risk, occupational exposure and the debrisoquine metabolic phenotype, Cancer Res. 49:3675-3679.
4. Ciotti, M., Marrone, A., Potter, C., and Owens, I. S. 1997. Genetic polymorphism in the human UGT1A6(planar phenol) UDP-glucuronosyltransferase: Pharmacological implications. Pharmacogenetics 7:485-495.
5. Dosemeci, M., Yin, S. N., Linet, M., Wacholder, S., Rothman, N., Li, G. L., Chow, W. H., Wang, Y. Z., Jiang, Z. L., Dai, T. R., Zhang, W. U., Chao, X. J., Ye, P. Z., Kou, Q. R., Fan, Y. H., Zhang, X. C., Lin, X. F., Meng, J. F., Zho, J. S., Blot, W. J., and Hayes, R. B. 1996. Indirect validation of benzene exposure assessment by association with benzene poisoning. Environ. Health Perspect. 104(suppl.6):1343-1347.
6. Gu, D., Wu, X., Reynolds, K., Duan, X., Xin, X., Reynolds, R. F., Whelton, P. K., He, J., and InterASIA Collaborative Group. 2004. Cigarette smoking and exposure to environmental tobacco smoke in China: The international collaborative study of cardiovascular disease in Asia. Am. J. Public. Health 94:1972-1976.
7. Hao, W., Su, Z., Liu, B., Zhang, K., Yang, H., Chen, S., Biao, M., and Cui, C. 2004. Drinking and drinking patterns and health status in the general population of five areas of China. Alcohol Alcoholism 39:43-52.
8. Hayes, R. B., Yin, S. N., Dosemeci, M., Li, G. L., Wacholder, S., Travis, L. B., Li, C. Y., Rothman, N., Hoover, R. N., and Linet, M. S. 1997. Benzene and the dose-related incidence of hematologic neoplasms in China. Chinese academy of preventive medicine, national cancer institute benzene study group, JNCI 89:1065-1071.
9. Hayes, R. B., Yin, S., Rothman, N., Dosemeci, M., Li, G., Travis, L. T., Smith, M. T., and Linet, M. S. 2000. Benzene and lympohematopoietic malignancies in China. J. Toxicol. Environ. Health A 61:419-432.
10. Henderson, R. F., Sabourin, P. J., Bechtold, W. E., Griffith, W. C., Medinsky, M. A., Birnbaum, L. S., and Lucier, G. W. 1989. The effect of dose, dose rate, route of administration, and species on tissue and blood levels of benzene metabolites. Environ. Health Perspect. 82:9-17.
11. Heim, M., and Meyer, U. A. 1990. Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification. Lancet 336:529-532.
12. Hemminki, K., Dickey, C., Karlsson, S., Bell, D., Hsu, Y., Tsai, W. Y., Mooney, L. V. A., Savela, K., and Perera, F. P. 1997. Aromatic DNA adducts in foundry workers in relation to exposure, life style and CYP1A1 and glutathione transferase M1 genotype. Carcinogenesis 18:345-350.
13. Inoue, H., Kiyohara, C., Marugame, T., Shinomiya, S., Tsuji, E., Handa, K., Hayabuchi, H., Onuma, K., Hamada, H., Koga, H., and Kono, S. 2000. Cigarette smoking, CYP1A1 MspI and GSTM1 genotypes, and colorectal adenomas. Cancer Res. 60:3749-3752.
14. Jiafang, Z., Jiachun, W., Yunxia, L., Xiaoxia, Q., and Ya, F. 2004. Alcohol abuse in a metropolitan city in China: A study of the prevalence and risk factors. Addiction 99:1103-1110.
15. Johansson, I., Yue, Q. Y., Dahl, M. L., Heim, M., Sawe, J., Bertilsson, L., Meyer, U. A., Sjoqvist, F., and Ingelman-Sundberg, M. 1991. Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine. Eur. J. Clin. Pharmacol. 40:553-556.
16. Jones, A. L., Hagen, M., Coughtrie, M. W. H., Roberts, R. C., and Glatt, H. 1995. Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form. Biochem. Biophys. Res. Commun. 208:855-862.
17. Kagimoto, M., Heim, M., Kagimoto, K., Zeugin, T., and Meyer, U. A. 1990. Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. J. Biol. Chem. 265:17209-17214.
18. Kawajiri, K., Nakachi, K., Imai, K., Yoshii, A., Shinoda, N., and Watanabe, J. 1990. Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450 IA1 gene. FEBS Lett. 263:131-133.
19. Miners, J. O., McKinnon, R. A., and Mackenzie, P. I. 2002. Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance. Toxicology 27:456-456.
20. Mucci, L. A., Wedren, S., Tamimi, R. M., Trichopoulos, D., and Adami, H. O. 2001. The role of gene-environment interaction in the etiology of human cancer: Examples from cancers of the large bowel, lung and breast. J. Intern. Med. 249:477-493.
21. Nagar, S., Zalatoris, J. J., and Blanchard, R. L. 2004. Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics 14:487-499.
22. Nakachi, K., Imai, K., Hayashi, S., and Kawajiri, K. 1993. Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population. Cancer Res. 53:2994-2999.
23. Nebert, D. W. 1991. Role of genetics and drug metabolism in human cancer risk, Mutat. Res. 247: 267-281.
24. Raftogianis, R. B., Wood, T. C., Otterness, D. M., van Loon, J. A., and Weinshilboum, R. M. 1997. Phenol sulfotransferase pharmacogenetics in humans: Association of common SULT1A1 alleles with TS PST phenotype. Biochem. Biophys. Res. Commun. 239: 298-304.
25. Ross, D. 2000. The role of metabolism and specific metabolites in benzene-induced toxicity: evidence and issues. J. Toxicol. Environ. Health A 61:357-372.
26. Snyder, R. 2000. Overview of the toxicology of benzene. J. Toxicol. Environ. Health A 61:339-346.
27. Snyder, R., and Hedli, C. C. 1996. An overview of benzene metabolism. Environ. Health Perspect. 104:1165-1171.
28. Seiji, K., Jin, C., Watanabe, T., Nakatsuka, H., and Ikeda, M. 1990. Sister chromatid exchanges in peripheral lymphocytes of workers exposed to benzene, trichloroethylene, or tetrachloroethylene, with reference to smoking habits. Int. Arch. Occup. Environ. Health 62:171-176.
29. Subrahmanyam, V. V., Kolachana, P., and Smith, M. T. 1991. Hydroxylation of phenol to hydroquinone catalyzed by a human myeloperoxidase-superoxide complex: Possible implications in benzene-induced myelotoxicity. Free Radical Res. Commun. 15:285-296.
30. Strassburg, C. P., Vogel, A., Kneip, S., Tukey, R. H., and Manns, M. P. 2002. Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. Gut 50:748-749.
31. Villeneuve, L., Girard, H., Fortier, L. C., Gagne, J. F., and Guillemette, C. 2003. Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. J. Pharmacol. Exp. Ther. 307:117-128.
32. Wang, S. L., Huang, J. D., Lai, M. D., Liu, B. H., and Lai, M. L. 1993. Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: Polymorphism in RFLP and DNA sequene of CYP2D6. Clin. Pharmacol. Ther. 53:410-418.
33. Wan, J., Shi, J., Hui, L., Wu, D., Jin, X., Zhao, N., Huang, W., Xia, Z., and Hu, G. 2002. Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning. Environ. Health Perspect. 110:1213-1218.
34. WHO Working Group. 1996. Updating and REVISION of the Air Quality Guidelines for Europe; Report on the WHO Working Group on Volatile Organic Compounds. EUR/ICP/EHAZ9405/MT12.
35. Wong, O. 2000. Recent findings and new initiatives for epidemiologic research on benzene. J. Toxicol. Environ. Health A 61:457-466.
36. Xu, X., Kelsey, K. T., Wiencke, J. K., Wain, J. C., and Christiani, D. C. 1996. Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility. Cancer Epidemiol. Biomarkers Prev. 5:687-692.