Detection of nandrolone administration to the entire male horse by a provisional concentration threshold for urinary oestranediol determined by gas chromatography-mass spectrometry

Equine Veterinary Journal

Volumn 39, Issue 2, 2007, Pages 186-188

  Dehennin, L ^a   Bonnaire, Y ^a   Plou, P ^a  

^a Laboratoire des Courses Hippiques   (France)

Author keywords

Gas chromatography mass spectrometry; Horse; Nandrolone; Oestranediol; Stallion; Threshold

Indexed keywords

EQUIDAE;

ANDROGEN; BIOLOGICAL MARKER; ESTRANE DERIVATIVE; NANDROLONE;

ANIMAL; ANIMAL DISEASE; AREA UNDER THE CURVE; ARTICLE; HORSE; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; METHODOLOGY; REFERENCE VALUE; URINE;

ANDROGENS; ANIMALS; AREA UNDER CURVE; BIOLOGICAL MARKERS; ESTRANES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HORSES; MALE; NANDROLONE; REFERENCE VALUES;

EID: 34247862148     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516407X170418     Document Type: Article

References (9)

1. Dehennin, L., Bonnaire, Y. and Plou, P. (2002) Human nutritional supplements in the horse: comparative effects of 19-norandrostenedione and 19-norandrostenediol on the 19-norsteroid profile and consequences for doping control. J. Chromatogr. B 766, 257-263.
2. Dehennin, L., Reiffsteck, A. and Scholler, R. (1980) Simple methods for the synthesis of twenty different, highly enriched deuterium labelled steroids, suitable as internal standards for isotope dliution mass spectrometry. Biomed. Mass Spectrom. 7, 493-499.
3. Dehennin, L., Petit, E., Bonnaire, Y., Bruyas, J-F., Le Bizec, B. and Plou, P. (2007) Urinary excretion of 5(10)-estrene-3β,17α-diol and estrone by the female horse: complementary indicators of early pregnancy screened with regard to a putative anabolic doping practice. J. Steroid Biochem. Mol. Biol. Jan 5; [Epub ahead of print].
4. Dumasia, M.C., Houghton, E. and Jackiw, M. (1989) Steroids in equine testes: the identification of endogenous 19-hydroxy and 19-nor neutral steroids by gas chromatography-mass spectrometry. J. Endocrinol. 120, 223-229.
5. Eisenhauer, K.M., McCue, P.M., Nayden, D.K., Osawa, Y. and Roser, J.F. (1994) Localization of aromatase in equine Leydig cells. Domest. Anim. Endocrinol. 11, 291-298.
6. Houghton, E. (1977) Studies related to the metabolism of anabolic steroids in the horse: 19-nortestosterone. Xenobiotica 7, 683-693.
7. Houghton, E., Copsey, J., Dumasia, M.C., Haywood, P.E., Moss, M.S. and Teale, P. (1984) The identification of C-18 neutral steroids in normal stallion urine. Biomed. Mass Spectrom. 11, 96-99.
8. Houghton, E., Ginn, A., Teale, P., Dumasia, M.C. and Moss, M.S. (1986) Detection of administration of anabolic preparations of nandrolone to the entire male horse. Equine vet. J. 18, 491-493.
9. Reiffsteck, A., Dehennin, L. and Scholler, R. (1982) Estrogens in seminal fluid of human and animal species: Identification and quantitative estimation by gas chromatography-mass spectrometry associated with stable isotope dilution. J. Steroid Biochem. 17, 567-572.