Effect of flumazenil-augmentation on microsleep and mood in depressed patients during partial sleep deprivation

Journal of Psychiatric Research

Volumn 41, Issue 10, 2007, Pages 876-884

  Hemmeter, Ulrich ^a,b   Hatzinger, Martin ^b   Brand, Serge ^b   Holsboer Trachsler, Edith ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Flumazenil; GABA; Major depression; Microsleep; Polysomnography; Sleep deprivation

Indexed keywords

FLUMAZENIL; MOOD STABILIZER; PLACEBO; TRIMIPRAMINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ELECTROENCEPHALOGRAM; FEMALE; GABAERGIC SYSTEM; HUMAN; MAJOR DEPRESSION; MALE; MONOTHERAPY; MOOD CHANGE; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SLEEP DEPRIVATION;

EID: 34247860847     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2006.07.004     Document Type: Article

References (40)

1. Bech P., Gram L.F., Dein E., Jacobsen O., Vitger J., and Bolwig T.G. Quantitative rating of depressive states. Acta Psychiatrica Scandinavica 51 (1975) 161-170
2. Borbèly A.A. A two process model of sleep regulation. Human Neurobiology 1 (1982) 195-204
3. Cheetham S.C., Crompton M.R., Katona C.L., Parker S.J., and Horton R.W. Brain GABAA/benzodiazepine binding sites and glutamic acid decarboxylase activity in depressed suicide victims. Brain Research 460 1 (1988) 114-123 September 13
4. Duka T., Ackenheil M., Noderer J., Doenicke A., and Dorow R. Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15-1788. Psychopharmacology (Berl.) 90 3 (1986) 351-357
5. Flugy A., Gagliano M., Cannizzaro C., Novara V., and Cannizzaro G. Antidepressant and anxiolytic effects of alprazolam versus the conventional antidepressant desipramine and the anxiolytic diazepam the forced swim test in rats. European Journal of Pharmacology 214 2-3 (1992) 233-238 April 22
6. Freye E., and Fournell A. Postoperative reversal of loss of vigilance following midazolam with the use of the antagonist flumazenil (Ro 15-1788). A comparative study with a placebo and the use of EEG-power spectra. Anaesthesist 37 3 (1988) 162-166
7. Gaillard J.M., and Blois R. Differential effects of flunitrazepam on human sleep in combiantion with flumazenil. Sleep 12 2 (1989) 120-132
8. Giedke H., and Schwarzler F. Therapeutic use of sleep deprivation in depression. Sleep Medicine Reviews 6 5 (2002) 361-377
9. Hamilton M. Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6 (1967) 278-296
10. Hemmeter U., Bischof R., Hatzinger M., Seifritz E., and Holsboer-Trachsler E. Microsleep during partial sleep deprivation in depression. Biology of Psychiatry 43 (1998) 829-839
11. Hemmeter U., Hatzinger M., Seifritz E., and Holsboer-Trachsler E. GABAergic modulation during PSD, effects on microsleep and NonREM-sleep in volunteers and patients with major depression. Pharmacopsychiatry 36 5 (2003) 232
12. Higgitt A., Lader M., and Fonagy P. The effects of the benzodiazepine antagonist Ro 15-1788 on psychophysiological performance and subjective measures in normal subjects. Psychopharmacology (Berl). 89 4 (1986) 395-403
13. Holsboer-Trachsler E., and Ernst K. Sustained antidepressive effect of repeated partial sleep deprivation. Psychopathology 19 2 (1986) 172-176
14. Knowles J.B., Southmayd S.E., Delva N., Maclean A.W., Cairns J., and Letemendia F.J. Five variations of sleep deprivation in a depressed woman. British Journal of Psychiatry 135 (1979) 403-410
15. Lancel M. Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and agonists. Sleep 22 1 (1999) 33-42 February 1
16. Lavie P. Ro 15-1788 decreases hypnotic effects of sleep deprivation 1987. Life Science 41 2 (1987) 227-233 July 13
17. Lavie P. Intrinsic effects of the benzodiazepine receptor antagonist RO 15-1788 in sleepy and alert subjects. International Journal of Neuroscience 46 (1989) 131-137
18. Leibenluft E., and Wehr T.A. Is sleep deprivation useful in the treatment of depression?. American Journal of Psychiatry 149 2 (1992) 159-168
19. Lloyd K.G., Zivkovic B., Scatton B., Morselli P.L., and Bartholini G. The gabaergic hypothesis of depression. Progresse in Neuropsychopharmacology and Biological Psychiatry 13 3-4 (1989) 341-351
20. Mendelson W.B. Sleep-inducing effects of adenosine microinjections into the medial preoptic area are blocked by flumazenil. Brain Research 852 2 (2000) 479-481 January 10
21. Miyata S., Hirano S., and Kamei J. Abnormal benzodiazepine receptor function in the depressive-like behavior of diabetic mice. Pharmacology Biochemistry and Behaviour 82 4 (2005) 615-620
22. Ozone M., Itoh H., Ohbuchi K., Ohyama E., Hayashida K., Sato M., et al. The effects of flumazenil on sleepiness, task performance and nocturnal sleep after anesthesia with midazolam. Psychiatry and Clinical Neuroscience 55 3 (2001) 235-237
23. Patat A., Naef M.M., van Gessel E., Forster A., Dubruc C., and Rosenzweig P. Flumazenil antagonizes the central effects of zolpidem, an imidazopyridine hypnotic. Clinical Pharmacology and Therapeutics 56 4 (1994) 430-436
24. Petty F., Trivedi M.H., Fulton M., and Rush A.J. Benzodiazepines as antidepressants: does GABA play a role in depression?. Biological Psychiatry 38 9 (1995) 578-591 November 1
25. Pregler J.L., Mo M.S., and Steen S.N. Effectiveness of flumazenil on return of cognitive functions after a general anestetic. Acta Anaesthesiology 32 2 (1994) 153-158
26. In: Rechtschaffen A., and Kales A. (Eds). A manual of standardized terminology techniques and scoring system for sleep stages of human subjects (1968), Public Health Service, US Government Printing Office, Washington (DC)
27. Riemann D., Wiegand M., Lauer C.J., and Berger M. Naps after total sleep deprivation in depressed patients: are they depressiogenic?. Psychiatry Research 49 2 (1993) 109-120
28. Seifritz E., Hemmeter U., Traxel L., Lauer C.J., Hatzinger M., Emrich H.M., et al. Effects of flumazenil on recovery sleep and hormonal secretion after sleep deprivation in male controls. Psychopharmacology 120 (1995) 449-456
29. Sonntag A., Rothe B., Guldner J., Yassouridis A., Holsboer F., and Steiger A. Trimipramine and imipramine exert different effects on the sleep EEG and on nocturnal hormone secretion during treatment of major depression. Depression 4 1 (1996) 1-13
30. Steiger A., Guldner J., Lauer C.J., Meschenmoser C., Pollmächer T., and Holsboer F. Flumazenil exerts intrinsic activity on sleep EEG and nocturnal hormone secretion in normal controls. Psychopharmacology 113 3-4 (1994) 334-338
31. Ware J.C., Brown F.W., Moorad Jr. P.J., Pittard J.T., and Cobert B. Effects on sleep: a double-blind study comparing trimipramine to imipramine in depressed insomniac patients. Sleep 12 6 (1989) 537-549
32. Wesensten N.J., Balkin T.J., Davis H.Q., and Belenky G.L. Reversal of triazolam- and zolpidem-induced memory impairment by flumazenil. Psychopharmacology 121 2 (1995) 242-249
33. Wiegand M., and Berger M. Action of trimipramine on sleep and pituitary hormone secretion. Drugs 38 Suppl. 1 (1989) 35-42
34. Wiegand M., Berger M., Zulley J., Lauer C., and von Zerssen D. The influence of daytime naps on the therapeutic effect of sleep deprivation. Biological Psychiatry 22 (1987) 389-392
35. Wiegand M., Riemann D., Schreiber W., Lauer C.J., and Berger M. Effect of morning naps on mood after total sleep deprivation in patients with major depression. Biological Psychiatry 33 (1993) 467-476
36. Wiegand M.H., Veselý Z., Krumbholz V., Kronseder J., and Diplich S. Antidepressant effect of sleep deprivation: relationship with spontaneous sleep episodes. Journal of Sleep Research 11 Suppl. 1 (2002) 251
37. Wirz-Justice A., Benedetti F., Berger M., Lam R.W., Martiny K., Terman M., et al. Chronotherapeutics (light and wake therapy) in affective disorders. Psychological Medicine 35 7 (2005) 939-944
38. Wittchen U, Zaudig M, Schramm E, Spengler P, Mombour W, Klug J, et al. Strukturiertes klinisches Interview für DSM-III-R. Deutschsprachige erweiterte Bearbeitung der amerikanischen Orginalversion des SCID von R.L. Spitzer, J.B.W. Williams M. Gibbon, Weinheim: Beltz-Test; 1987.
39. Wu J.C., and Bunney W.E. The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis. American Journal of Psychiatry 147 (1990) 1297-1303
40. Ziegler G., Ludwig L., and Fritz G. Reversal of slow wave sleep by benzodiazepine antagonist Ro 15-1788. Lancet 2 (1986) 8453 510