Efficient synthesis of protected l-phosphonophenylalanine (Ppa) derivatives suitable for solid phase peptide synthesis

Tetrahedron Letters

Volumn 48, Issue 23, 2007, Pages 4051-4054

  Chauhan, Satendra S ^a   Varshney, Arti ^a   Verma, Bhavana ^a   Pennington, Michael W ^a  

^a Bachem Holding AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 IODOPHENYLALANINE; PALLADIUM; PHENYLALANINE DERIVATIVE; PHOSPHITE; PHOSPHONOPHENYLALANINE DERIVATIVE; PHOSPHOTYROSINE; TRIETHYLAMINE; UNCLASSIFIED DRUG;

ARBUZOV REACTION; ARTICLE; CHEMICAL BOND; CHEMICAL STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; PEPTIDE SYNTHESIS; SOLID PHASE SYNTHESIS;

EID: 34247858965     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.04.027     Document Type: Article

References (18)

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7. 3): δ 7.75-7.70 (m, 2H), 7.70-7.65 (m, 1H), 7.50-7.45 (m, 1H), 4.95-5.1 (d, br, 1H), 4.65-4.55 (m, br, 1H), 4.20-4.10 (m, 4H), 4.10- 4.04 (m, 2H), 3.25-3.15 (dd, 1H), 3.15-3.05 (dd, 1H), 1.40 (s, 9H), 1.30 (t, 6H), 1.25 (t, 3H).
8. 6): δ 7.95-7.85 (d, 2H), 7.80-7.75 (d, 1H), 7.75-7.65 (m, 2H), 7.65- 7.55 (m, 2H), 7.45-7.35 (m, 2H), 7.35-7.25 (m, 2H), 4.28-4.10 (overlapping, m, 4H), 3.25-3.15 (m, 1H), 2.95-2.85 (m, 1H).
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14. 3): δ 7.76-7.54 (m, 2H), 7.37-7.24 (m, 2H), 5.32-5.15 (d, 1H), 4.69-4.55 (m, 1H), 3.34-3.17 (m, 2H), 1.43 (s, 9H), 1.41 (s, 9H), 1.40 (s, 9H).
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18. 6): δ 7.87-7.81 (d, 2H), 7.70-7.55 (br, m, 4H), 7.55-7.35 (m, 2H), 7.35- 7.25 (m, 2H), 7.25-7.10 (br, m, 7H), 4.65 (s, 2H), 4.30-4.12 (overlapping, m, 4H), 3.12-3.05 (br, m, 1H), 2.95-2.88 (br, m, 1H).