Cytokine-induced osteoprotegerin expression protects pancreatic beta cells through p38 mitogen-activated protein kinase signalling against cell death

Diabetologia

Volumn 50, Issue 6, 2007, Pages 1243-1247

  Schrader, J ^a,c   Rennekamp, W ^a,d   Niebergall, U ^a   Schoppet, M ^a   Jahr, H ^b   Brendel, M D ^b   Horsch D ^a,e   Hofbauer, L C ^a,f  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d KLINIKUM DORTMUND   (Germany)

^e Central Clinic Bad Berka   (Germany)

^f DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Apoptosis; Beta cell; Cytokine; Diabetes; IL 1 ; MAPK; Osteoprotegerin; p38

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYTOKINE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOPROTEGERIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CELL DEATH; CELL SURVIVAL; HUMAN; HUMAN CELL; IMMUNOASSAY; NORTHERN BLOTTING; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; CELL DEATH; CELL LINE; CYTOKINES; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; KINETICS; OSTEOPROTEGERIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34247857465     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0672-6     Document Type: Article

References (11)

1. Eizirik DL, Mandrup-Poulsen T (2001) A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44:2115-2133
2. Shapiro AM, Ricordi C, Hering BJ et al (2006) International trial of the Edmonton protocol for islet transplantation. N Engl J Med 355:1318-1330
3. Robertson RP (2004) Islet transplantation as a treatment for diabetes - a work in progress. N Engl J Med 350:694-705
4. Saldeen J, Lee JC, Welsh N (2001) Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis. Biochem Pharmacol 61:1561-1569
5. Kong YY, Boyle WJ, Penninger JM (2000) Osteoprotegerin ligand: a regulator of immune responses and bone physiology. Immunol Today 21:495-502
6. Hofbauer LC, Kluger S, Kühne CA et al (2002) Detection and characterization of RANK ligand and osteoprotegerin in the thyroid gland. J Cell Biochem 86:642-650
7. Cardozo AK, Kruhoffer M, Leeman R, Orntoft T, Eizirik DL (2001) Identification of novel cytokine-induced genes in pancreatic β-cells by high-density oligonucleotide arrays. Diabetes 50:909-920
8. Huang L, Xu JK, Wood DJ, Zheng MH (2000) Gene expression of osteoprotegerin ligand, osteoprotegerin, and receptor activator of NF-kB in giant cell tumor of bone. Possible involvement in tumor cell-induced osteoclast-like cell formation. Am J Pathol 156:761-767
9. Emery JG, McDonnell P, Burke MB et al (1998) Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem 273:14363-14367
10. Ou D, Metzger DL, Wang X, Huang J, Pozzilli P, Tingle AJ (2002) TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction. Diabetologia 45:1678-1688
11. Standal T, Seidel C, Hjertner O et al (2002) Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells. Blood 100:3002-3007