Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 11, 2007, Pages 3028-3033

  Ho, Ginny D ^a   Bercovici, Ana ^a   Tulshian, Deen ^a   Greenlee, William J ^a   Fawzi, Ahmad ^a   Fernandez, Xiomara ^a   McLeod, Robbie L ^a   Smith Torhan, April ^a   Zhang, Hongtao ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

G protein coupled receptor; Nociceptin; Nociceptin receptor (NOP); Opioid receptor like 1 (ORL 1); Opioid receptors (MOP, KOP, DOP); Orphnin FQ

Indexed keywords

4 HYDROXY 2 PHENYLPIPERIDINE DERIVATIVE; ANTITUSSIVE AGENT; NOCICEPTIN; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTITUSSIVE AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; GUINEA PIGS; HUMANS; LIGANDS; PIPERIDINES; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247855968     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.062     Document Type: Article

References (15)

1. Please see the preceding paper in this journal.
2. Mollereau C., Parmentier M., Mailleux P., Butour J., Moisand C., Chalon P., Caput D., Vassart G., and Meunier J.-C. FEBS Lett. 341 (1994) 33
3. Fukada k., Kato S., Mori K., Nishi M., Takeshima H., Iwabe N., Miyata T., Houtani T., and Sugomoto T. FEBS Lett. 343 (1994) 42
4. Chen Y., Fan Y., Liu J., Mestek A., Tian M., Kozak C.A., and Yu L. FEBS Lett. 347 (1994) 279
5. Wang J.B., Johnson P.S., Imai Y., Persico A.M., Ozenberger B.A., Eppler C.M., and Uhl G.R. FEBS Lett. 348 (1994) 75
6. Meunier J.-C., Mollereau C., Toll L., Suaudeau C., Moisand C., Alvinerie P., Butour J.-L., Guillemot J.-C., Ferrara P., Monsarrat B., Mazarguil H., Vassart G., Parmentier M., and Costentin J. Nature 377 (1995) 532
7. Reinscheid R.K., Nothacker H.P., Bourson A., Ardati A., Henningsen R.A., Bunzow J.R., Grandy D.K., Langen H., Monsma Jr. F.J., and Civelli O. Science 270 (1995) 792
8. Mcleod R.L., Parra L.E., Mutter J.C., Erickson C.H., Carey G.J., Tulshian D.B., Fawzi A.B., Smith-Torhan A., Egan R.W., Cuss F.M., and Hey J. Br. J. Pharmacol. 132 6 (2001) 1175
9. Mcleod R.L., Bolster D.C., Jia Y., Parra L.E., Mutter J.C., Wang X., Tulshian D.B., Egan R.W., and Hey J.A. Pulm. Pharmacol. Ther. 15 3 (2002) 213
10. Meunier J.-C. Expert Opin. Ther. Patents 10 (2000) 371 and references cited therein
11. Bignan G.C., Connolly P.J., and Middleton S.A. Expert Opin. Ther. Patents 15 4 (2005) 357 and references cited therein
12. Calo G., Guerrini R., Rizzi A., Salvadori S., and Regoli D. Br. J. Pharmacol. 129 7 (2000) 1261 and references cited therein
13. Allen C.N., Jiang Z.-G., Teshima K., Darland T., Ikeda M., Nelson C.S., Quigley D.I., Yoshioka T., Allen R.G., Rea M.A., and Grandy D.K. J. Neurosci. 2152 (1999)
14. Teshima, K.; Minoguchi, M. World Patent 2003082333, 2003; Chem. Abstr. 2003, 139, 302062.
15. Fawzi A.B., Zhang H., Weig B., Hawes B., and Graziano M.P. Eur. J. Pharmacol. 336 (1997) 233