Theophylline improves esophageal chest pain - A randomized, placebo-controlled study

American Journal of Gastroenterology

Volumn 102, Issue 5, 2007, Pages 930-938

  Rao, Satish S C ^a,b   Mudipalli, Ranjit S ^a   Remes Troche, Jose M ^a   Utech, Craig L ^a   Zimmerman, Bridget ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; THEOPHYLLINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DIZZINESS; DOUBLE BLIND PROCEDURE; ESOPHAGUS; ESOPHAGUS PAIN; FEMALE; HUMAN; HYPERSENSITIVITY; INSOMNIA; MALE; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENSORIMOTOR FUNCTION; THORAX PAIN; TREMOR;

ADULT; AGED; BALLOON DILATATION; BIOMECHANICS; CHEST PAIN; DOUBLE-BLIND METHOD; ELECTRIC IMPEDANCE; ESOPHAGEAL DISEASES; FEMALE; HUMANS; MALE; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; RECURRENCE; REGRESSION ANALYSIS; STATISTICS, NONPARAMETRIC; THEOPHYLLINE; TREATMENT OUTCOME;

EID: 34247854759     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2007.01112.x     Document Type: Article

References (50)

1. Clouse RE, Richter JE, Heading RC, et al. Functional esophageal disorders. In : Drossman AD, Corazziari E, Talley NJ, et al., eds. Rome II: The functional gastrointestinal disorders. McLean, VA : Degnon Associates, 2000 : 247 98.
2. Ockene IS, Shay MJ, Alpert JS, et al. Unexplained chest pain in patients with normal coronary arteriograms: A follow up study of functional status. N Engl J Med 1980 303 : 1249 52.
3. Ward BW, Wu WC, Richter JE, et al. Long-term follow up of symptomatic status of patients with noncardiac chest pain: Is diagnosis of esophageal etiology helpful? Am J Gastroenterol 1987 82 : 215 8.
4. DeMeester TR, O'Sullivan G, Bermudez G, et al. Esophageal function in patients with angina-type chest pain and normal coronary angiograms. Ann Surg 1982 196 : 488 98.
5. Achem SR, DeVault KR. Unexplained chest pain at the turn of the century. Am J Gastroenterol 1999 94 : 5 8.
6. Singh S, Richter J, Hewson EG, et al. The contribution of gastroesophageal reflux to chest pain in patients with coronary artery disease. Ann Intern Med 1992 117 : 824 30.
7. Faybush EM, Fass R. Gastroesophageal reflux disease in noncardiac chest pain. Gastroenterol Clin North Am 2004 33 : 41 54.
8. Roth H, Fleshler B. Diffuse esophageal spasm. Ann Intern Med 1964 61 : 914 23.
9. Katz P, Codario R, Castell D. Approach to the patient with unexplained chest pain. Compr Ther 1997 23 : 249 253.
10. Van Handel D, Fass R. The pathophysiology of non-cardiac chest pain. J Gastroenterol Hepatol 2005 20 : S6 13.
11. Mujica V, Mudipalli R, Rao S. Pathophysiology of chest pain in patients with nutcracker esophagus. Am J Gastroenterol 2001 96 : 1371 7.
12. Clouse R, Lustman P. Psychiatric illness and contraction abnormalities of the esophagus. N Engl J Med 1983 309 : 1337 42.
13. Cannon RO 3rd, Benjamin SB. Chest pain as a consequence of abnormal visceral nociception. Dig Dis Sci 1993 38 : 193 6.
14. Olden KW. The psychological aspects of noncardiac chest pain. Gastroenterol Clin North Am 2004 33 : 61 7.
15. Richter JE, Barish CF, Castell DO. Abnormal sensory perception in patients with esophageal chest pain. Gastroenterology 1986 91 : 845 52.
16. Rao S, Gregersen H, Hayek B, et al. Unexplained chest pain: The hypersensitive, hyperreactive, and poorly compliant esophagus. Ann Intern Med 1996 124 : 950 8.
17. Rao S, Hayek B, Summers R. Functional chest pain of esophageal origin: Hyperalgesia or motor dysfunction. Am J Gastroenterol 2001 96 : 2584 9.
18. Sarkar S, Aziz Q, Woolf CJ, et al. Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet 2000 356 : 1154 9.
19. Lembo AJ. Visceral hypersensitivity in noncardiac chest pain. Gastroenterol Clin North Am 2004 33 : 55 60.
20. Varaia I, Logue E, O'Connor C, et al. Randomized trial of sertraline in patients with unexplained chest pain of noncardiac origin. Am Heart J 2000 140 : 367 72.
21. Sarkar S, Aziz Q, Woolf CJ, et al. Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet 2000 356 : 1154 9.
22. Sawynok J. Adenosine receptor activation and nociception. Eur J Pharmacol 1998 347 : 1 11.
23. Bueno L, Fioramanti J, Delvaux M, et al. Mediators and pharmacology of visceral sensitivity: From basic to clinical investigations. Gastroenterology 1997 112 : 1714 43.
24. Bleehen T, Keele CA. Observation on the algogenic actions of adenosine compounds on the human blister base preparation. Pain 1997 3 : 367 77.
25. Taiwo YO, Levine JD. Direct cutaneous hyperalgesia induced by adenosine. Neuroscience 1990 38 : 756 62.
26. Pappagallo M, Gaspardone A, Tomai F, et al. Analgesic effect of bamiphylline on pain induced by intradermal injection of adenosine. Pain 1993 53 : 199 204.
27. Sylven C, Beerman B, Jonzon B, et al. Angina pectoris like pain provoked by intravenous adenosine in healthy volunteers. BMJ 1986 293 : 227 30.
28. Crea F, Pupita G, Galassi AR, et al. Role of adenosine in pathogenesis of anginal pain. Circulation 1990 81 : 164 72.
29. Minton NA, Henry JA. Pharmacodynamic interaction between infused adenosine and oral theophylline. Hum Exp Toxicol 1991 10 : 411 8.
30. Rao S, Mudipalli R, Mujica V, et al. An open-label trial of theophylline for functional chest pain. Dig Dis Sci 2002 47 : 2763 8.
31. Rao SSC, Hayek B, Summers RW. Impedance planimetry: An integrated approach for assessing sensory, active and passive biomechanical properties of the esophagus. Am J Gastroenterol 1995 90 : 431 8.
32. Patel RS, Rao SSC. Biomechanical and sensory parameters of the esophagus at four levels. Am J Physiol 1998 275 : G187 91.
33. Chahal PS, Rao SS. Functional chest pain: Nociception and visceral hyperalgesia. J Clin Gastroenterol 2005 39 : S204 9.
34. Dickman R, Emmons S, Cui H, et al. The effect of a therapeutic trial of high-dose rabeprazole on symptom response of patients with non-cardiac chest pain: A randomized, double-blind, placebo-controlled, crossover trial. Aliment Pharmacol Ther 2005 22 : 547 55.
35. Eslick GD, Fass R. Noncardiac chest pain: Evaluation and treatment. Gastroenterol Clin North Am 2003 32 : 531 52.
36. Achem SR, Kolts BE, MacMath T, et al. Effects of omeprazole versus placebo in treatment of noncardiac chest pain and gastroesophageal reflux. Dig Dis Sci 1997 42 : 2138 45.
37. Botoman V. Noncardiac chest pain. J Clin Gastroenterol 2002 34 : 6 14.
38. Fang J, Bjorkman D. A critical approach to noncardiac chest pain: Pathophysiology, diagnosis and treatment. Am J Gastroenterol 2001 96 : 958 68.
39. Langdon DE. Empiric therapy for noncardiac chest pain. Arch Intern Med 2000 160 : 3331.
40. Sylven C. Mechanisms of pain in angina pectoris - a critical review of the adenosine hypothesis. Cardiovasc Drugs Ther 1993 7 : 745 59.
41. Edlund A, Conradsson T, Sollevi A. A role for adenosine in coronary vasoregulation in man. Effects of theophylline and enprofylline. Clin Physiol 1995 15 : 623 36.
42. Mittal RK, Holloway R, Dent J. Effect of atropine on the frequency of reflux and transient lower esophageal sphincter relaxation in normal subjects. Gastroenterology 1995 109 : 1547 54.
43. Christofi FL. Unlocking mysteries of gut sensory transmission: Is adenosine the key? News Physiol Sci 2001 : 16 : 201 7.
44. Gaspardone A, Crea F, Tomai F, et al. Muscular and cardiac adenosine-induced pain is mediated by A1 receptors. J Am Col Cardiol 1995 25 : 251 7.
45. Johannesson N, Andersson KE, Joelsson B, et al. Relaxation of lower esophageal sphincter and stimulation of gastric secretion and diuresis by antiasthmatic xanthines. Role of adenosine antagonism. Am Rev Respir Dis 1985 131 : 26 30.
46. Ekstrom T, Tibbling L. Influence of theophylline on gastro-oesophageal reflux and asthma. Eur J Clin Pharmacol 1988 35 : 353 6.
47. Broekaert D, Fischler B, Sifrim D, et al. Influence of citalopram, a selective serotonin reuptake inhibitor, on oesophageal hypersensitivity: A double-blind, placebo-controlled study. Aliment Pharmacol Ther 2006 23 : 365 70.
48. Rodriguez-Stanley S, Zubaidi S, Proskin HM, et al. Effect of tegaserod on esophageal pain threshold, regurgitation and symptom relief in patients with functional heartburn and mechanical sensitivity. Clin Gastroenterol Hepatol 2006 4 : 442 50.
49. Clouse RE, Carney RM. The psychological profile of non-cardiac chest pain patients. Eur J Gastroenterol Hepatol 1995 7 : 1160 5.
50. Patel SM, Stason WB, Legedza A, et al. The placebo effect in irritable bowel syndrome trials: A meta-analysis. Neurogastroenterol Motil 2005 17 : 332 40.