Extrapolating from animal studies to the efficacy in humans of a pretreatment combination against organophosphate poisoning

Archives of Toxicology

Volumn 81, Issue 5, 2007, Pages 353-359

  Levy, Aharon ^a   Cohen, Giora ^a   Gilat, Eran ^a   Kapon, Joseph ^a   Dachir, Shlomit ^a   Abraham, Shlomo ^a   Herskovitz, Miriam ^a   Teitelbaum, Zvi ^a   Raveh, Lily ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

Caramiphen; Clearance; Pharmacokinetics; Prophylaxis; Pyridostigmine; Steady state

Indexed keywords

CARAMIPHEN; PYRIDOSTIGMINE; SARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICHOLINERGIC SYNDROME; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG INFUSION; FEMALE; LETHAL DOSE; MALE; MONKEY; NONHUMAN; PLASMA CLEARANCE; PREDICTION; PRIORITY JOURNAL; SINGLE DRUG DOSE; STEADY STATE; THERAPY EFFECT; TREATMENT RESPONSE;

ANIMALS; CHEMICAL WARFARE AGENTS; CHOLINERGIC ANTAGONISTS; CYCLOPENTANES; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; INFUSIONS, PARENTERAL; LETHAL DOSE 50; MALE; METABOLIC CLEARANCE RATE; PAPIO ANUBIS; PHOSPHORIC ACID ESTERS; POISONING; PYRIDOSTIGMINE BROMIDE; SARIN; SPECIES SPECIFICITY; TREATMENT OUTCOME;

ANIMALIA; CANIS FAMILIARIS;

EID: 34247853297     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-006-0153-6     Document Type: Article

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