Comparison of Mortality Benefit of Immediate Thrombolytic Therapy Versus Delayed Primary Angioplasty for Acute Myocardial Infarction

American Journal of Cardiology

Volumn 99, Issue 10, 2007, Pages 1384-1388

  Kent, David M ^a   Ruthazer, Robin ^a   Griffith, John L ^a   Beshansky, Joni R ^a   Grines, Cindy L ^b   Aversano, Thomas ^d   Concannon, Thomas W ^a   Zalenski, Robert J ^c   Selker, Harry P ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b WILLIAM BEAUMONT HOSPITAL   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE HEART INFARCTION; ADULT; AGED; ANGIOPLASTY; ARTICLE; BLOOD CLOT LYSIS; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA BASE; DRUG EFFECT; FEMALE; FIBRINOLYTIC THERAPY; HUMAN; INTERMETHOD COMPARISON; LOGISTIC REGRESSION ANALYSIS; MALE; MATHEMATICAL MODEL; MORTALITY; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION; THERAPY DELAY;

AGED; ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; DATABASES, FACTUAL; FEMALE; HEART CONDUCTION SYSTEM; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PREDICTIVE VALUE OF TESTS; RANDOMIZED CONTROLLED TRIALS; REGISTRIES; RESEARCH DESIGN; RISK ASSESSMENT; RISK FACTORS; SURVIVAL ANALYSIS; THROMBOLYTIC THERAPY; TIME FACTORS; TREATMENT OUTCOME;

EID: 34247644421     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2006.12.068     Document Type: Article

References (29)

1. Selker H.P., Griffith J.L., Beshansky J.R., Schmid C.H., Califf R.M., D'Agostino R.B., Laks M.M., Lee K.L., Maynard C., Selvester R.H., Wagner G.S., and Weaver W.D. Patient-specific predictions of outcomes in myocardial infarction for real-time emergency use: a thrombolytic predictive instrument. Ann Intern Med 127 (1997) 538-548
2. Selker H.P., Griffit J.L., Beshansky J.R., Califf R.M., D'Agostino R.B., Laks M.M., Lee K.L., Maynard C., Wagner G.S., and Weaver W.D. The Thrombolytic Predictive Instrument (TPI) Project: Combining Clinical Study Databases to Take Medical Effectiveness Research to the Streets (1992), Agency for Health Care Policy Research, Department of Health and Human Services, Rockville, MD 9-31
3. Selker H.P., Beshansky J.R., Griffith J.L., and TPI Trial Investigators. Use of the electrocardiograph-based thrombolytic predictive instrument to assist thrombolytic and reperfusion therapy for acute myocardial infarction. A multicenter, randomized, controlled, clinical effectiveness trial. Ann Intern Med 137 (2002) 87-95
4. Selker H.P., Beshansky J.R., Griffith J.L., Aufderheide T.P., Ballin D.S., Bernard S.A., Crespo S.G., Feldman J.A., Fish S.S., Gibler W.B., et al. Use of the acute cardiac ischemia time-insensitive predictive instrument (ACI-TIPI) to assist with triage of patients with chest pain or other symptoms suggestive of acute cardiac ischemia: a multicenter, controlled clinical trial. Ann Intern Med 129 (1998) 845-855
5. Grines C.L., Browne K.F., Marco J., Rothbaum D., Stone G.W., O'Keefe J., Overlie P., Donohue B., Chelliah N., Timmis G.C., et al., Primary Angioplasty in Myocardial Infarction Study Group. A comparison of immediate coronary angioplasty with thrombolytic therapy for acute myocardial infarction. N Engl J Med 328 (1993) 673-679
6. Grines C.L., Marsalese D.L., Brodie B., Griffin J., Donohue B., Costantini C.R., Balestrini C., Stone G., Wharton T., Esente P., et al. Safety and cost-effectiveness of early discharge after primary angioplasty in low risk patients with acute myocardial infarction. J Am Coll Cardiol 31 (1998) 967-972
7. Stone G.W., Marsalese D., Brodie B.R., Griffin J.J., Donohue B., Costantini C., Balestrini C., Wharton T., Esente P., Spain M., et al., Second Primary Angioplasty in Myocardial Infarction (PAMI-II) Trial Investigators. A prospective, randomized evaluation of prophylactic intraaortic balloon counterpulsation in high risk patients with acute myocardial infarction treated with primary angioplasty. J Am Coll Cardiol 29 (1997) 1459-1467
8. Grines C.L., Westerhausen Jr. D.R., Grines L.L., Hanlon J.T., Logemann T.L., Niemela M., Weaver W.D., Graham M., Boura J., O'Neill W.W., Balestrini C., and Air PAMI Study Group. A randomized trial of transfer for primary angioplasty versus on-site thrombolysis in patients with high-risk myocardial infarction: the Air Primary Angioplasty in Myocardial Infarction study. J Am Coll Cardiol 39 (2002) 1713-1719
9. Wharton T.P., Grines L.L., Turco M.A., Johnston J.D., Souther J., Lew D.C., Shaikh A.Z., Bilnoski W., Singhi S.K., Atay A.E., et al. Primary angioplasty in acute myocardial infarction at hospitals with no surgery on-site (the PAMI-No SOS study) versus transfer to surgical centers for primary angioplasty. J Am Coll Cardiol 43 (2004) 1943-1950
10. Every N.R., Spertus J., Fihn S.D., Hlatky M., Martin J.S., and Weaver W.D. Length of hospital stay after acute myocardial infarction in the Myocardial Infarction Triage and Intervention (MITI) Project registry. J Am Coll Cardiol 28 (1996) 287-293
11. Every N.R., Parsons L.S., Fihn S.D., Larson E.B., Maynard C., Hallstrom A.P., Martin J.S., Weaver W.D., and MITI Investigators. Long-term outcome in acute myocardial infarction patients admitted to hospitals with and without on-site cardiac catheterization facilities. Myocardial Infarction Triage and Intervention. Circulation 96 (1997) 1770-1775
12. Selker H.P., Raitt M.H., Schmid C.H., Laks M.M., Beshansky J.R., Griffith J.L., Califf R.M., Selvester R.H., Maynard C., D'Agostino R.B., and Weaver W.D. Time-dependent predictors of primary cardiac arrest in patients with acute myocardial infarction. Am J Cardiol 91 (2003) 280-286
13. Antoniucci D., Valenti R., Migliorini A., Moschi G., Trapani M., Buonamici P., Cerisano G., Bolognese L., and Santoro G.M. Relation of time to treatment and mortality in patients with acute myocardial infarction undergoing primary coronary angioplasty. Am J Cardiol 89 (2002) 1248-1252
14. Thune J.J., Hoefsten D.E., Lindholm M.G., Mortensen L.S., Andersen H.R., Nielsen T.T., Kober L., Kelbaek H., and Danish Multicenter Randomized Study on Fibrinolytic Therapy Versus Acute Coronary Angioplasty in Acute Myocardial Infarction (DANAMI)-2 Investigators. Simple risk stratification at admission to identify patients with reduced mortality from primary angioplasty. Circulation 112 (2005) 2017-2021
15. Kent D.M., Schmid C.H., Lau J., and Selker H.P. Is primary angioplasty for some as good as primary angioplasty for all?. Modeling across trials and individual patients. J Gen Intern Med 17 (2002) 887-894
16. Kent D.M., Hayward R.A., Griffith J.L., Vijan S., Beshansky J.R., Califf R.M., and Selker H.P. An independently derived and validated predictive model for selecting patients with myocardial infarction who are likely to benefit from tissue plasminogen activator compared with streptokinase. Am J Med 113 (2002) 104-111
17. Hayward R.A., Kent D.M., Vijan S., and Hofer T.P. Multivariable risk prediction can greatly enhance the statistical power of clinical trial subgroup analysis. BMC Med Res Methodol 6 (2006) 18
18. Hayward R.A., Kent D.M., Vijan S., and Hofer T.P. Reporting clinical trial results to inform providers, payers, and consumers. Health Affairs 24 (2005) 1571-1581
19. Morrow D.A., Antman E.M., Charlesworth A., Cairns R., Murphy S.A., de Lemos J.A., Giugliano R.P., McCabe C.H., and Braunwald E. TIMI risk score for ST-elevation myocardial infarction: a convenient, bedside, clinical score for risk assessment at presentation: an InTIME II trial substudy. Circulation 102 (2000) 2031-2037
20. Rothwell P.M., Warlow C.P., and European Carotid Surgery Trialists' Collaborative Group. Prediction of benefit from carotid endarterectomy in individual patients: a risk-modeling study. Lancet 353 (1999) 2105-2110
21. Rothwell P.M., Mehta Z., Howard S.C., Gutnikov S.A., and Warlow C.P. Treating individuals 3: from subgroups to individuals: general principles and the example of carotid endarterectomy. Lancet 365 (2005) 256-265
22. Kent D., and Hayward R. When averages hide individual differences in clinical trials. Am Scientist 95 (2007) 60-68
23. Kent D.M., Lau J., and Selker H.P. Balancing the benefits of primary angioplasty over thrombolytic therapy against the risks of procedure-related delay: a meta-regression. Effective Clin Pract 4 (2001) 214-220
24. Nallamothu B.K., and Bates E.R. Percutaneous coronary intervention versus fibrinolytic therapy in acute myocardial infarction: is timing (almost) everything?. Am J Cardiol 92 (2003) 824-826
25. Schmid C.H., Stark P.C., Berlin J.A., Landais P., and Lau J. Meta-regression detected associations between heterogeneous treatment effects and study-level, but not patient-level, factors. J Clin Epidemiol 57 (2004) 683-697
26. Thompson S.G., and Higgins J.P. Treating individuals 4: can meta-analysis help target interventions at individuals most likely to benefit?. Lancet 365 (2005) 341-346
27. Magid D.J., Calonge B.N., Rumsfeld J.S., Canto J.G., Frederick P.D., Every N.R., Barron H.V., and National Registry of Myocardial Infarction 2 and 3 Investigators. Relation between hospital primary angioplasty volume and mortality for patients with acute MI treated with primary angioplasty vs thrombolytic therapy. JAMA 284 (2000) 3131-3138
28. Boersma E., and Primary Coronary Angioplasty vs. Thrombolysis (PCAT)-2 Trialists' Collaborative Group. Does time matter?. A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J 27 (2006) 779-788
29. Pinto D.S., Kirtane A.J., Nallamothu B.K., Murphy S.A., Cohen D.J., Laham R.J., Cutlip D.E., Bates E.R., Frederick P.D., Miller D.P., et al. Hospital delays in reperfusion for ST-elevation myocardial infarction: implications when selecting a reperfusion strategy. Circulation 114 (2006) 2019-2025