Lrrking in the background: Common pathways of neurodegeneration [6]

Journal of the American Geriatrics Society

Volumn 55, Issue 5, 2007, Pages 804-805

  Ross, Owen A ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; LEUCINE RICH REPEAT KINASE 2; TAU PROTEIN; UBIQUITIN;

CELL LOSS; DIFFUSE LEWY BODY DISEASE; ETHNICITY; FAMILIAL DISEASE; GENE LOCUS; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; LETTER; MUSCLE ATROPHY; NERVE CELL; NERVE DEGENERATION; NEUROPATHOLOGY; PARKINSON DISEASE; PARKINSONISM; PATHOGENESIS; PHENOTYPE; PROGRESSIVE SUPRANUCLEAR PALSY;

HUMANS; MUTATION; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES;

EID: 34247641855     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2007.01167.x     Document Type: Letter

References (10)

1. Farrer MJ. Genetics of Parkinson disease: Paradigm shifts and future prospects. Nat Rev Genet 2006 7 : 306 318.
2. Zimprich A, Biskup S, Leitner P et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 2004 44 : 601 607.
3. Wszolek ZK, Pfeiffer RF, Tsuboi Y et al. Autosomal dominant parkinsonism associated with variable synuclein and tau pathology. Neurology 2004 62 : 1619 1622.
4. Wszolek ZK, Vieregge P, Uitti RJ et al. German-Canadian family (family A) with parkinsonism, amyotrophy, and dementia: Longitudinal observations. Parkinsonism Relat Disord 1997 3 : 125 139.
5. Kachergus J, Mata IF, Hulihan M et al. Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: Evidence of a common founder across European populations. Am J Hum Genet 2005 76 : 672 680.
6. Ross OA, Toft M, Whittle AJ et al. Lrrk2 and Lewy body disease. Ann Neurol 2006 59 : 388 393.
7. Giasson BI, Covy JP, Bonini NM et al. Biochemical and pathological characterization of Lrrk2. Ann Neurol 2006 59 : 315 322.
8. Rajput A, Dickson DW, Robinson CA et al. Parkinsonism, Lrrk2 G2019S, and tau neuropathology. Neurology 2006 67 : 1506 1508.
9. Farrer MJ, Stone JT, Lin CH et al. Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia. Parkinsonism Relat Disord 2007 13 : 89 92.
10. Smith WW, Pei Z, Jiang H et al. Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat Neurosci 2006 9 : 1231 1233.