Cyclosporin a has a protective effect with induced upregulation of Hsp70 and nNOS on severe spinal cord ischemic injury in rabbits

Journal of Investigative Surgery

Volumn 20, Issue 2, 2007, Pages 113-120

  Shin, Yoon Cheol ^a   Choi, Ki Young ^b   Kim, Won Gon ^b  

^a Hallym University   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

Cyclosporin A; Spinal cord protection

Indexed keywords

CYCLOSPORIN A; HEAT SHOCK PROTEIN 70; NEURONAL NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CERVICAL SPINE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG MECHANISM; FEMALE; GENE OVEREXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INJURY SEVERITY; MALE; NEUROLOGIC DISEASE; NEUROLOGICAL COMPLICATION; NEUROPATHOLOGY; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RISK REDUCTION; SCORING SYSTEM; SPINAL CORD ISCHEMIA; UPREGULATION;

ANIMALS; CYCLOSPORINE; FEMALE; HSP70 HEAT-SHOCK PROTEINS; IN SITU NICK-END LABELING; MALE; NITRIC OXIDE SYNTHASE TYPE II; PROTECTIVE AGENTS; RABBITS; SPINAL CORD; SPINAL CORD INJURIES; SPINAL CORD ISCHEMIA; UP-REGULATION;

EID: 34247636111     PISSN: 08941939     EISSN: 15210553     Source Type: Journal    
DOI: 10.1080/08941930701235833     Document Type: Article

References (20)

1. Mauney, M. C., Blackbourne, L. H., Langenburg, S. E., Buchanan, S. A., Kron, I. L. and Tribble, C. G. (1995) Prevention of spinal cord injury after repair of the thoracic or thoracoabdominal aorta. Ann Thorac Surg, 59, pp. 245-252.
2. Coselli, J. S., Conflin, L. D. and LeMaire, S. A. (2002) Thoracoabdominal aortic aneurysm repair: Review and update of current strategies. Ann Thorac Surg, 74, pp. S1881-S1884.
3. Kuniyoshi, Y., Koja, K., Miyagi, K., Shimoji, M., Uezu, T., Arakaki, K., Yamashiro, S., Mabuni, K., Senaha, S. and Nakasone, Y. (2003) Prevention of postoperative paraplegia during thoracoabdominal aortic surgery. Ann Thorac Surg, 76, pp. 1477-1484.
4. Shiga, Y., Onodera, H., Matsuo, Y. and Kogure, K. (1992) Cyclosporin a protects against ischemia - reperfusion injury in the brain. Brain Res, 595, pp. 145-148.
5. Sato, M., Horinouchi, T., Sakurai, M., Murakami, N., Sato, S. and Kato, M. (2003) Cyclosporin A reduces delayed motor neuron death after spinal cord ischemia in rabbits. Ann Thorac Surg, 75, pp. 1294-1299.
6. Lee, C. H., Choi, K. Y., Kim, Y. J. and Kim, W. G. (2005) Neuroprotective effect of KR-31378, a novel potassium channel activator, on spinal cord ischemic injury in rabbits. J Invest Surg, 18, pp. 297-304.
7. Johnson, S. H., Kraimer, J. M. and Graeber, G. M. (1993) Effects of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in 20 rabbits. Stroke, 24, pp. 1547-1553.
8. Cassada, D. C., Tribble, C. G., Long, S. M., Long, S. M., Kaza, A. K., Linden, J., Rieger, J. M., Rosin, D., Kron, I. L. and Kern, J. A. (2002) Adenosine A2A agonist reduces paralysis after spinal cord ischemia: Correlation with A2A receptor expression on motor neurons. Ann Thorac Surg, 74, pp. 728-733.
9. Chen, H. W., Chien, C. T., Yu, S. L., Lee, Y. T. and Chen, W. J. (2002) Cyclosporin A regulates oxidative stress-induced apoptosis in cardiomyocytes: Mechanism via ROS generation, iNOS and Hsp70. Br J Pharmacol, 137, pp. 771-781.
10. Tarlov, I. M. (1957) Spinal Cord Compression: Mechanisms of Paralysis and Treatment, p. 147. Charles C. Thomas, Springfield, IL
11. Wakamatsu, Y., Shiiya, N., Kunihara, T., Watanabe, S. and Yasuda, K. (2001) The adenosine triphosphate-sensitive potassium channel opener nicornadil protects the ischemic rabbit spinal cord. J Thorac Cardiovasc Surg, 122, pp. 728-733.
12. Caparrelli, D. J., Cattaneo 2nd, S. M., Bethea, B. T., Shake, J. G., Eberhart, C., Blue, M. E., Marban, E., Johnston, M. V., Baumgartner, W. A. and Gott, V. L. (2002) Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia. Ann Thorac Surg, 74, pp. 838-845.
13. Borutaite, V., Jekabsone, A., Morkuniene, R. and Brown, G. C. (2003) Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia. J Mol Cell Cardiol., 35, pp. 357-366.
14. Charriaut-Marlangue, C. and Ben-Ari, Y. (1995) Acautionary note on the use of the TUNEL stain to determine apoptosis. NeuroReport, 7, pp. 61-64.
15. Glick, B. S. (1995) Can HSP70 proteins act as force-generating motors?. Cell, 80, pp. 11-14.
16. Martin, J. L., Mestril, R., Hilal-Dandan, R., Brunton, L. L. and Dillmann, W. H. (1997) Small heat shock proteins and protection against ischemic injury in cardiac myocyte. Circulation, 96, pp. 4343-4348.
17. Kleindienst, R. and Wick, G. (1997) Nitric oxcide induces heat shock proteins 70 expression in vascular smooth muscle cells via activation of heat shock factor I. J ClinInvest., 100, pp. 1089-1097.
18. Rajdev, S., Hara, K., Kokubo, Y., Mestril, R., Dillmann, W., Weinstein, P. R. and Sharp, R. (2000) Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann Neurol, 47, pp. 782-779.
19. Sharp, A. R., Tang, Y. and Milhorn, D. E. (2000) Multiple molecular penumbras after focal cerebral ischemia. J Cereb Blood Flow Metab, 20, pp. 1011-1032.
20. Yan, X. B., Meng, F. J. and Zhang, G. Y. (2004) Brain ischemia induces serine phosphorylation of neuronal nitric oxcide synthase by Ca(2+)/ calmodulin-dependent protein kinase II in rat hippocampus. Acta Pharmacol Sin, 25, pp. 617-622.