Correlation of apparent affinity values from H 3-receptor binding assays with apparent affinity (pK app) and intrinsic activity (α) from functional bioassays

British Journal of Pharmacology

Volumn 151, Issue 1, 2007, Pages 109-124

  Harper, E A ^a   Shankley, N P ^a,b   Black, J W ^a  

^a James Black Foundation   (United Kingdom)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

3H clobenpropit; Histamine H 3 receptors

Indexed keywords

2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; 4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; ALPHA METHYLHISTAMINE; BROMOPROXYFAN; BUFFER; CALCIUM CHLORIDE; CHLOROPROXYFAN; CLOBENPROPIT; GR 175737; GT 2227; HISTAMINE; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR AGONIST; HISTAMINE H3 RECEPTOR ANTAGONIST; IMETIT; IODOPROXYFAN; JB 16132; JB 95130; JB 96132; JB 96134; JB 97034; LIGAND; POTASSIUM CHLORIDE; PROXYFAN; SODIUM CHLORIDE; SODIUM HYDROXIDE; THIOPERAMIDE; TRITIUM; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; DRUG DERIVATIVE; IMIDAZOLE DERIVATIVE; QUINOLINE DERIVATIVE; THIOUREA;

AGONIST; ANALYTICAL ERROR; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; BINDING COMPETITION; BIOASSAY; BRAIN CORTEX; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFICACY; DRUG RECEPTOR BINDING; GUINEA PIG; ILEUM; ILEUM CONTRACTION; ISOTHERM; LIGAND BINDING; MALE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR INTRINSIC ACTIVITY; ANIMAL; DRUG EFFECT; METABOLISM; PHYSIOLOGY; RADIOASSAY;

ANIMALS; BIOLOGICAL ASSAY; BUFFERS; CALCIUM CHLORIDE; GUINEA PIGS; ILEUM; IMIDAZOLES; MALE; QUINOLINES; RADIOLIGAND ASSAY; RECEPTORS, HISTAMINE H3; THIOUREA; TRITIUM;

EID: 34247636107     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707174     Document Type: Article

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