Synthesis of (S,R,R,R)-α,α′-iminobis(methylene)bis(6- fluoro-3H,4H-dihydro-2H-1-benzopyran-2-methanol)

Synthesis

Volumn , Issue 8, 2007, Pages 1154-1158

  Wang, Nai Xing ^a   Yu, An Guang ^a   Wang, Gui Xia ^a   Zhang, Xiu Hui ^b   Li, Qian Shu ^b   Li, Zhen ^b  

^a TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY   (China)

^b BEIJING INSTITUTE OF TECHNOLOGY   (China)

Author keywords

(S,R,R,R) nebivolol; Chiral pool; Cyclization; Synthesis design

Indexed keywords

ADRENERGIC ANTAGONIST; COMPUTER MODELING; CONVERGENT SYNTHETIC STRATEGY; NATURAL CHIRAL POOL;

COMPUTER SIMULATION; CYCLIZATION; SYNTHESIS (CHEMICAL);

METHANOL;

1 (6 FLUORO 3,4 DIHYDRO 2H CHROMEN 2 YL)ETHANE 1,2 DIOL[3]; 2 (2,2 DIMETHYL 1,3 DIOXOLAN 4 YL) 6 FLUORO 2,3 DIHYDROCHROMEN 4 ONE[4]; 2 (6 FLUORO 3,4 DIHYDRO 2H CHROMEN 2 YL) 2 HYDROXYETHYL 4 METHYLBENZENESULFONATE[2]; 2 ACETYL 4 FLUOROPHENOL; 2 AMINO 1 (6 FLUORO 3,4 DIHYDRO 2H CHROMEN 2 YL)ETHANOL[2A]; 2,3 ISOPROPYRIDINEGLYCEROLALDEHYDE; ALPHA,ALPHA' IMINOBIS(METHYLENE)BIS(6 FLOURO 3H,4H DIHYDRO 2H 1 BENZOPYRAN 2 METHANOL); ALPHA,ALPHA'[IMINOBIS(METHYLENE)]BIS(6 FLOURO 3H,4H DIHYDRO 2H 1 BENZOPYRAN 2 METHANOL); BETA ADRENERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; COMPUTER MODEL; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 34247629154     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-965993     Document Type: Article

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