Synthesis of 8-(2′-deoxy-β-d-ribofuranosyl)imidazo[1,2-a]-s-triazin-4-one

Tetrahedron Letters

Volumn 48, Issue 22, 2007, Pages 3801-3803

  Hanami, Takeshi ^a   Oda, Hiroshi ^a   Nakamura, Akiko ^b   Urata, Hisao ^b   Itoh, Masayoshi ^a   Hayashizaki, Yoshihide ^a  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 (2' DEOXY BETA DEXTRO RIBOFURANOSYL)IMIDAZO[1,2 A] TRIAZIN 4 ONE; NUCLEOSIDE DERIVATIVE; PROTON; PURINE NUCLEOSIDE; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; EPIMERIZATION; ISOMERISM; PROTEIN DNA INTERACTION; SYNTHESIS;

EID: 34247616000     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.03.157     Document Type: Article

References (13)

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9. 3): δ 170.1, 169.7, 150.2, 150.1, 148.8, 148.4, 115.5, 115.1, 109.2, 108.5, 85.8, 84.7, 84.6, 74.3, 74.0, 63.6, 38.1, 37.8, 37.7, 20.8.
10. Kim S.-H., Bartholomew D.G., and Allen L.B. J. Med. Chem. 21 (1978) 883-889
11. Michel J., Toulmé J.-J., Vercauteren J., and Moreau S. Nucleic Acids Res. 24 (1996) 1127-1135
12. 6): δ 8.61 (s, 1H), 7.74 (d, 1H, J = 1.5 Hz), 7.38 (d, 1H, J = 1.5 Hz), 6.29 (t, 1H, J = 6.3 Hz, C-1′), 5.40-5.05 (br, 2H, 3′-OH and 5′-OH), 4.35-4.28 (m, 1H, C-3′), 3.90-3.84 (m, 1H, C-4′), 3.72-3.57 (m, 2H, C-5′), 2.42-2.35 (m, 1H, C-2′), 2.34-2.26 (m, 1H, C-2′).
13. 6): δ 8.46 (s, 1H), 7.74 (d, 1H, J = 1.5 Hz), 7.38 (d, 1H, J = 1.5 Hz), 6.27 (d, 1H, J = 5.9 Hz, C-1′), 5.30 (d, 1H, J = 2.9 Hz, 3′-OH), 4.93-4.91 (m, 1H, 5′-OH), 4.40-4.20 (m, 2H, C-3′ and C-4′), 3.45-3.38 (2H, m, C-5′), 2.72-2.60 (m, 1H, C-2′), 2.20-2.14 (m, 1H, C-2′).