Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate

Protein Science

Volumn 16, Issue 5, 2007, Pages 983-989

  Andreassi II, John L ^a   Bilder, Patrick W ^b   Vetting, Matthew W ^b   Roderick, Steven L ^b   Leyh, Thomas S ^b  

^a DUPONT COMPANY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Allosteric inhibitor; Antimicrobial target; Crystal structure; Diphosphomevalonate; GHMP kinase; Mevalonate deficiency; Mevalonate kinase; Streptococcus pnuemoniae

Indexed keywords

DIPHOSPHOMEVALONATE; MEVALONATE KINASE; MEVALONIC ACID; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; STREPTOCOCCUS PNEUMONIAE;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; MEVALONIC ACID; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STREPTOCOCCUS PNEUMONIAE;

POSIBACTERIA; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

EID: 34247609151     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.072755707     Document Type: Article

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