Synthesis and evaluation of transthyretin amyloidosis inhibitors containing carborane pharmacophores

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 12, 2007, Pages 4808-4813

  Julius, Richard L ^a,b   Farha, Omar K ^a,c   Chiang, Janet ^a   Perry, L Jeanne ^a   Hawthorne, M Frederick ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Missouri   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

Author keywords

Amyloid; Cyclooxygenase; Fibril; Nonsteroidal antiinflammatory drug

Indexed keywords

1 CARBOXYLIC ACID 7 (3 FLUOROPHENYL) 1,7 DICARBADODECABORANE; AMYLOID; CARBORANE DERIVATIVE; CARRIER PROTEIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DIFLUNISAL; FLUFENAMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PREALBUMIN; THYROXINE; UNCLASSIFIED DRUG; BORANE DERIVATIVE;

AMYLOIDOSIS; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STABILITY; BIOSYNTHESIS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; PH; SYNTHESIS;

AMYLOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BORANES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DIFLUNISAL; FLUFENAMIC ACID; HUMANS; HYDROGEN-ION CONCENTRATION; PREALBUMIN;

EID: 34247608204     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700316104     Document Type: Article

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