Respiratory syncytial virus infection in adults

Seminars in Respiratory and Critical Care Medicine

Volumn 28, Issue 2, 2007, Pages 171-181

  Falsey, Ann R ^a,b  

^a ROCHESTER GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Lower respiratory tract infection; Respiratory syncytial virus (RSV); Respiratory viruses

Indexed keywords

IMMUNOGLOBULIN; RESPIRATORY SYNCYTIAL VIRUS VACCINE; RIBAVIRIN;

ARTICLE; ASTHMA; BRONCHIOLITIS; CHRONIC LUNG DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL FEATURE; COMMUNITY ACQUIRED PNEUMONIA; COMORBIDITY; COMPLEMENT FIXATION TEST; ENZYME IMMUNOASSAY; EPIDEMIC; HUMAN; HUMORAL IMMUNITY; IMMUNOCOMPROMISED PATIENT; IMMUNOFLUORESCENCE TEST; INFECTION CONTROL; INFECTION RATE; LABORATORY TEST; LOWER RESPIRATORY TRACT INFECTION; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYMPTOMATOLOGY; UPPER RESPIRATORY TRACT INFECTION; VACCINATION; VIRAL RESPIRATORY TRACT INFECTION; VIROLOGY; VIRUS CULTURE; VIRUS DIAGNOSIS;

AGED; AGED, 80 AND OVER; ANTIVIRAL AGENTS; ASTHMA; COMMUNICABLE DISEASE CONTROL; COMMUNICABLE DISEASES; CROSS INFECTION; HOMES FOR THE AGED; HUMANS; MIDDLE AGED; NURSING HOMES; PNEUMONIA, VIRAL; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS VACCINES; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; RIBAVIRIN;

EID: 34247606799     PISSN: 10693424     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-976489     Document Type: Article

References (130)

1. Chanock R, Roizman B, Myers R. Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). Am J Hyg 1957;66:281-290
2. Dowell SF, Anderson LJ, Gary HE Jr, et al. Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults. J Infect Dis 1996;174:456-462
3. Fleming DM, Cross KW. Respiratory syncytial virus or influenza? Lancet 1993;342:1507-1510
4. Thompson WW, Shay DK, Weintraub E, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003;289:179-186
5. Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med 2005;28:1749-1759
6. La Montagne JR. RSV pneumonia, a community-acquired infection in adults. Lancet 1997;349:149
7. Griffin M, Coffey CS, Neuzil KM, Mitchel EF, Wright PF, Edwards K. Winter viruses: influenza and respiratory syncytial virus-related morbidity in chronic lung disease. Arch Intern Med 2002;162:1229-1236
8. Englund JA, Sullivan CJ, Jordan MC, Dehner LP, Vercellotti GM, Balfour HH. Respiratory syncytial virus infection in immunocompromised adults. Ann Intern Med 1988;109:203-208
9. Mullooly JP, Bridges CB, Thompson WW, et al. Influenza and RSV-associated hospitalizations. Vaccine 2007;25:846-855
10. Collins P. The molecular biology of human respiratory syncytial viruses (RSV) of the genus Pneumovirus. In: Kingsbury DW, ed. The Paramyxoviruses. Plenum; 1991:103-162
11. Walsh EE, Hall CB, Briselli M, Brandriss MW, Schlesinger JJ. Immunization with glycoprotein subunits of respiratory syncytial virus to protect cotton rats against viral infection. J Infect Dis 1987;155:1198-1204
12. Walsh EE, Schlesinger JJ, Brandriss M. Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies. Infect Immun 1984; 43:756-758
13. Johnson PR, Spriggs MK, Olmsted RA, Collins PL. The G glycoprotein of human respiratory syncytial viruses of subgroups A and B: extensive sequence divergence between antigenically related proteins. Proc Natl Acad Sci USA 1987;84:5625-5629
14. Johnson PR, Olmsted RA, Prince GA, et al. Antigenic relatedness between glycoproteins of human respiratory syncytial virus subgroups A and B: evaluation of the contributions of F and G glycoproteins to immunity. J Virol 1987;61:3163-3166
15. Walsh EE, McConnochie KM, Long CE, Hall CB. Severity of respiratory syncytial virus infection is related to virus strain. J Infect Dis 1997;175:814-820
16. Hall CB. Respiratory syncytial virus and parainfluenza virus. N Engl J Med 2001;334:1917-1928
17. Hall CB, Walsh EE, Schnabel KC, et al. Occurrence of groups A and B of respiratory syncytial virus over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children. J Infect Dis 1990; 162:1283-1290
18. Anderson LJ, Hendry RM, Pierik LT, Tsou C, McIntosh K. Multicenter study of strains of respiratory syncytial virus. J Infect Dis 1991;163:687-692
19. Agius G, Dindinaud G, Biggar RJ, et al. An epidemic of respiratory syncytial virus in elderly people: clinical and serological findings. J Med Virol 1990;30:117-127
20. Centers for Disease Control. Epidemiologic notes and reports: respiratory syncytial virus-Missouri. MMWR 1977;26:351
21. Garvie DG, Gray J. Outbreak of respiratory syncytial virus infection in the elderly. BMJ 1980;281:1253-1254
22. Hart RJC. An outbreak of respiratory syncytial virus infection in an old people's home. J Infect 1984;8:259-261
23. Mandal SK, Joglekar VM, Khan AS. An outbreak of respiratory syncytial virus infection in a continuing-care geriatric ward. Age Ageing 1985;14:184-186
24. Public Health Laboratory Service Communicable Diseases Surveillance Centre. Respiratory syncytial virus infection in the elderly 1976-1982. Br Med J (Clin Res Ed) 1983;287:1618-1619
25. Sorvillo FJ, Huie SF, Strassburg MA, Butsumyo A, Shandera WX, Fannin SL. An outbreak of respiratory syncytial virus pneumonia in a nursing home for the elderly. J Infect 1984;9:252-256
26. Falsey AR, Treanor JJ, Betts RF, Walsh EE. Viral respiratory infections in the institutionalized elderly: clinical and epidemiologic findings. J Am Geriatr Soc 1992;40:115-119
27. Osterweil D, Norman D. An outbreak of an influenza-like illness in a nursing home. J Am Geriatr Soc 1990;38:659-662
28. Hornsleth A, Siggaard-Andersen J, Hjort L. Epidemiology of herpesvirus and respiratory virus infections, I: Serologic findings. Geriatrics 1975;30:61-68
29. Arroyo JC, Jordan W, Milligan L. Upper respiratory tract infection and serum antibody responses in nursing home patients. Am J Infect Control 1988;16:152-158
30. Mathur U, Bentley DW, Hall CB. Concurrent respiratory syncytial virus and influenza A infections in the institutionalized elderly and chronically ill. Ann Intern Med 1980; 93:49-52
31. Morales F, Calder MA, Inglis JM, Murdoch PS, Williamson J. A study of respiratory infection in the elderly to assess the role of respiratory syncytial virus. J Infect 1983;7:236-247
32. Gross PA, Rodstein M, LaMontagne JR, et al. Epidemiology of acute respiratory illness during an influenza outbreak in a nursing home. Arch Intern Med 1988;148:559-561
33. Nicholson KG, Baker DJ, Farquhar A, Hurd D, Kent J, Smith SH. Acute upper respiratory tract viral illness and influenza immunization in homes for the elderly. Epidemiol Infect 1990;105:609-618
34. Falsey AR, Walsh EE, Betts RF. Serologic evidence of respiratory syncytial virus infection in nursing home patients. J Infect Dis 1990;162:568-569
35. Wald TG, Miller BA, Shult P, Drinka P, Langer L, Gravenstein S. Can respiratory syncytial virus and influenza A be distinguished clinically in institutionalized older persons? J Am Geriatr Soc 1995;43:170-174
36. Orr PH, Peeling RW, Fast M, et al. Serological study of responses to selected pathogens causing respiratory tract infection in the institutionalized elderly. Clin Infect Dis 1996;23:1240-1245
37. Falsey AR, McCann RM, Hall WJ, et al. Acute respiratory tract infection in daycare centers for older persons. J Am Geriatr Soc 1995;43:30-36
38. Hall CB, Long CE, Schnabel KC. Respiratory syncytial virus infections in previously healthy working adults. Clin Infect Dis 2001;33:792-796
39. Nicholson KG, Kent J, Hammersley V, Esperanza C. Acute viral infections of upper respiratory tract in elderly people living in the community, comparative, prospective, population based study of disease burden. BMJ 1997;315:1060-1064
40. Zambon MC, Stockton JD, Clewley JP, Fleming DM. Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: an observational study. Lancet 2001;358:1410-1416
41. Fransen H, Heigl Z, Wolontis S, Forsgren M, Svedmyr A. Infections with viruses in patients hospitalized with acute respiratory illness, Stockholm 1963-1967. Scand J Infect Dis 1969;1:127-136
42. Fransen H, Sterner G, Forsgren M, et al. Acute lower respiratory illness in elderly patients with respiratory syncytial virus infection. Acta Med Scand 1967;182:323-329
43. Hers JFPh, Masurel N, Gans JC. Acute respiratory disease associated with pulmonary involvement in military servicemen in the Netherlands. Am Rev Respir Dis 1969;100:499-506
44. Vikerfors T, Grandien M, Olcen P. Respiratory syncytial virus infections in adults. Am Rev Respir Dis 1987; 136:561-564
45. Kimball AM, Foy HM, Cooney MK, Allan ID, Matlock M, Plorde JJ. Isolation of respiratory syncytial and influenza viruses from the sputum of patients hospitalized with pneumonia. J Infect Dis 1983;147:181-184
46. Stanek J, Heinz F. On the epidemiology and etiology of pneumonia in adults. J Hyg Epidemiol Microbiol Immunol 1988;1:31-38
47. Zaroukian MH, Leader I. Community-acquired pneumonia and infection with respiratory syncytial virus. Ann Intern Med 1988;109:515-516
48. Angeles Marcos MA, Camps M, Pumarola T, et al. The role of viruses in the aetiology of community-acquired pneumonia in adults. Antivir Ther 2006;11:351-359
49. Beckham JD, Cadena A, Lin J, et al. Respiratory viral infections in patients with chronic obstructive pulmonary disease. J Infect 2005;50:322-330
50. Buscho RO, Saxtan D, Shultz PS, Finch E, Mufson MA. Infections with viruses and Mycoplasma pneumoniae during exacerbations of chronic bronchitis. J Infect Dis 1978;137:377-383
51. Carilli AP, Gohd R, Gordon W. A virologic study of chronic bronchitis. N Engl J Med 1964;270:123-127
52. Fagon J-Y, Chastre J. Severe exacerbations of COPD patients: the role of pulmonary infections. Semin Respir Infect 1996;11:109-118
53. Glezen WP, Greenberg SB, Atmar RL, Piedra PA, Couch RB. Impact of respiratory virus infections on persons with chronic underlying conditions. JAMA 2000;283:499-505
54. Gump DW, Phillips CA, Forsyth BR. Role of infection in chronic bronchitis. Am Rev Respir Dis 1976;113:465-474
55. Lambert HP, Stern H. Infective factors in exacerbations of bronchitis and asthma. BMJ 1972;3:323-327
56. Lamy ME, Pouthier-Simon F, Debacker-Willame E. Respiratory viral infections in hospital patients with chronic bronchitis. Chest 1973;63:336-341
57. Rohde G, Wiethege A, Borg I, et al. Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study. Thorax 2003;58:37-42
58. Wiselka MJ, Kent J, Cookson JB, Nicholson KG. Impact of respiratory infection in patients with chronic chest disease. Epidemiol Infect 1993;111:337-346
59. Walsh EE, Falsey AR, Hennessey PA. Respiratory syncytial virus and other infections in persons with chronic cardiopulmonary disease. Am J Respir Crit Care Med 1999;160:791-795
60. Sommerville RG. Respiratory syncytial virus in acute exacerbations of chronic bronchitis. Lancet 1963;II:1247-1248
61. Borg I, Rohde G, Loseke S, et al. Evaluation of quantitative real-time PCR for the detection of respiratory syncytial virus in pulmonary diseases. Eur Respir J 2003;21:944-951
62. Seemungal TAR, Wedzicha JA. Viral infections in obstructive airway diseases. Curr Opin Pulm Med 2003;9:111-116
63. Seemungal T, Harper-Owen R, Angshu B, et al. Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001;164:1618-1623
64. Wilkinson TMA, Donaldson GC, Johnston SL, Openshaw PJM, Wedzicha JA. Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006;173:871-876
65. Schwarze J, O'Donnell DR, Rohwedder A, Openshaw PJM. Latency and persistence of respiratory syncytial virus despite T cell immunity. Am J Respir Crit Care Med 2004; 169:801-805
66. Falsey AR, Formica MA, Hennessey PA, Criddle M, Sullender WM, Walsh EE. Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005;173:639-643
67. Falsey AR, Walsh EE. Respiratory syncytial virus infection in adults. Clin Microbiol Rev 2000;13:371-384
68. Hudgel DW, Lelan L Jr, Selner JC, McIntosh K. Viral and bacterial infections in adults with chronic asthma. Am Rev Respir Dis 1979;120:393-397
69. Beasley R, Coleman ED, Hermon Y, Holst PE, O'Donnell TV, Tobias M. Viral respiratory tract infection and exacerbations of asthma in adult patients. Thorax 1988; 43:679-683
70. Han LL, Alexander JP, Anderson LJ. Respiratory syncytial virus pneumonia among the elderly: an assessment of disease burden. J Infect Dis 1999;179:25-30
71. Gentile DA, Doyle WJ, Zeevi A, Piltcher O, Skoner DP. Cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adults. Hum Immunol 2003; 64:93-98
72. Heinzmann A, Ahlert I, Kurz T, Beiner B, Deichmann KA. Association study suggests opposite effects of polymorphisms with IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol 2004; 114:671-676
73. Hull J, Thomson A, Kwiatkowski D. Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax 2000;55:1023-1027
74. Hull J, Ackerman H, Isles K, et al. Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus. Am J Hum Genet 2001;69:413-419
75. Tal G, Madelberg A, Dalal I, et al. Association between common Toll-like rector 4 mutations and severe respiratory syncytial virus disease. J Infect Dis 2004;189:2057-2063
76. Lamprecht CL, Krause HE, Mufson MA. Role of maternal antibody in pneumonia and bronchiolitis due to respiratory syncytial virus. J Infect Dis 1976;134:211-217
77. Groothuis JR, Simoes EAF, Levin MJ, et al. Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. N Engl J Med 1993;329:1524-1530
78. Groothuis JR, Simoes EAF, Hemming VG. Respiratory Syncytial Virus Immune Gobulin Study Group. Respiratory syncytial virus (RSV) infection in preterm infants and the protective effects of RSV immune globulin (RSVIG). Pediatrics 1995;95:463-467
79. Sorrentino M, Powers TPalivizumab Outcomes Study Group. Effectiveness of palivizumab: evaluation of outcomes from the 1998 to 1999 respiratory syncytial virus season. Pediatr Infect Dis J 2000;19:1068-1071
80. Hall CB, Walsh EE, Long CE, Schnabel KC. Immunity to and frequency of reinfection with respiratory syncytial virus. J Infect Dis 1991;163:693-698
81. Lee FE-H, Walsh EE, Falsey AR, Betts RF, Treanor JJ. Experimental infection of humans with A2 respiratory syncytial virus. Antiviral Res 2004;63:191-196
82. Walsh EE, Peterson DR, Falsey AR. Risk factors for severe respiratory syncytial virus infection in elderly adults. J Infect Dis 2004;189:233-238
83. Walsh EE, Falsey AR. Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults. J Infect Dis 2004;190:373-378
84. Walsh EE, Falsey AR. Age related differences in humoral immune response to respiratory syncytial virus infection in adults. J Med Virol 2004;73:295-299
85. Graham BS. Immunologic determinants of RSV-induced disease. Trends Microbiol 1996;4:290-293
86. Openshaw PJM. Immunity and immunopathology to respiratory syncytial virus. Am J Respir Crit Care Med 1995;152:S59-S62
87. Miller RA. The aging immune system: primer and prospectus. Science 1996;273:70-74
88. Abraham GN, Davis MM. Immune System: Functions and Changes Associated with Aging. Bethesda, MD: Report of the Task Force on Immunology and Aging. National Institute of Aging and National Institute of Allergy and Infectious Disease, U.S. Dept. of Health and Human Services; 1996. March 15
89. Adler WH, Song L, Chopra R. Immune deficiency of aging. In: Powers DC, Morley JE, Coe R, eds. Aging, Immunity and Infection. New York, NY: Springer; 1994:66-81
90. Pawelec G, Wagner W, Adibzadeh M, Engel A. T cell immunosenescence in vitro and in vivo. Exp Gerontol 1999; 34:419-429
91. Zhang Y, Wang Y, Gilmore X, Xu K, Wyde PR, Mbawuike IN. An aged mouse model for RSV infection and diminished CD8 + CTL responses. Exp Biol Med 2002; 227:133-140
92. Looney RJ, Falsey A, Walsh E, Campbell D. Effect of aging on cytokine production in response to respiratory syncytial virus infection. J Infect Dis 2002;185:682-685
93. Lee FEH, Walsh EE, Falsey AR, et al. The balance between influenza and RSV specific CD4 T cells secreting IL-10 or IFN gamma in young and healthy elderly subjects. Mech Ageing Dev 2005;126:1223-1229
94. de Bree GJ, Heidema J, van Leewen EMM, et al. Respiratory syncytial virus-specific CD8 + memory T cell responses in elderly persons. J Infect Dis 2005;191:1710-1718
95. Johnson KM, Bloom HH, Mufson MA, Chanock RM. Natural infection of adults by respiratory syncytial virus: possible relation to mild upper respiratory disease. N Engl J Med 1962;267:68-72
96. Hall WJ, Hall CB, Speers DM. Respiratory syncytial virus infection in adults: clinical, virologic, and serial pulmonary function studies. Ann Intern Med 1978;88:203-205
97. Shapiro JM, Jean RE. Respiratory syncytial virus. N Engl J Med 2001;345:1132-1133 (correspondence)
98. Walsh EE, Peterson DR, Falsey AR. Is clinical recognition of respiratory syncytial virus infection in hospitalized elderly. J Infect Dis 2007;195:1046-1051
99. Falsey AR, Cunningham CK, Barker WH, et al. Respiratory syncytial virus and influenza A infections in the hospitalized elderly. J Infect Dis 1995;172:389-394
100. Simpson JL, Moric I, Wark P, Johnston L, Gibson PG. Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic methods. J Clin Virol 2003;26:339-346
101. Englund JA, Piedra P, Jewell A, Baxter BB, Whimbey E, Patel K. Rapid diagnosis of respiratory syncytial virus infections in immunocompromised adults. J Clin Microbiol 1996;34:1649-1653
102. Falsey AR, McCann RM, Hall WJ, Criddle MM. Evaluation of four methods for the diagnosis of respiratory syncytial virus infection in older adults. J Am Geriatr Soc 1996;44:71-73
103. Ohm-Smith MJ, Nassos PS, Haller BL. Evaluation of the Binax NOW, BD Directigen, and BD Directigen EZ Assays for detection of respiratory syncytial virus. J Clin Microbiol 2004;42:2996-2999
104. Casiano-Colon AE, Hulbert BB, Mayer TK, Walsh EE, Falsey AR. Lack of sensitivity of rapid antigen tests for the diagnosis of respiratory syncytial infection in adults. J Clin Virol 2003;28:169-174
105. Borek AP, Clemens SH, Gaskins VK, Aird DZ, Valsamakis A. Respiratory syncytial virus detection by Remel Xpect, Binax NOW RSV, direct immunofluorescent staining, and tissue culture. J Clin Microbiol 2006;44:1105-1107
106. Fan J, Henrickson KJ, Savatski LL. Rapid simultaneous diagnosis of infections with respiratory syncytial viruses A and B, influenza viruses A and B, and human parainfluenza virus types 1, 2, and 3 by multiplex quantitative reverse transcription-polymerase chain reaction-enzyme hybridization (hexaplex) assay. Clin Infect Dis 1998;26:1397-1402
107. Freymuth F, Vabret A, Gourain S, et al. Epidemiology and diagnosis of respiratory syncytial virus in adults. Rev Mal Respir 2004;21:13-14
108. Freymuth F, Eugene G, Vabret A, et al. Detection of respiratory syncytial virus by reverse transcription-PCR and hybridization with a DNA enzyme immunoassay. J Clin Microbiol 1995;33:3352-3355
109. Falsey AR, Formica MA, Treanor JJ, Walsh EE. Comparison of quantitative reverse transcription-PCR to viral culture for assessment of respiratory syncytial virus shedding. J Clin Microbiol 2003;41:4160-4165
110. Falsey AR, Formica MA, Walsh EE. Diagnosis of respiratory syncytial virus infection: comparison of reverse transcription-PCR to viral culture and serology in adults with respiratory illness. J Clin Microbiol 2002;40:817-820
111. Moore C, Valappil M, Corden S, Westmoreland D. Enhanced clinical utility of the NucliSENS EasyQ RSV A + B assay for rapid detection of respiratory syncytial virus in clinical samples. Eur J Clin Microbiol Infect Dis 2006; 25:167-174
112. Erdman DD, Anderson LJ. Monoclonal antibody-based capture enzyme immunoassays for specific serum immunoglobulin G (IgG), IgA, and IgM antibodies to respiratory syncytial virus. J Clin Microbiol 1990;28:2744-2749
113. Vikerfors T, Grandien M, Johansson M, Pettersson C-A. Detection of an immunoglobulin M response in the elderly for early diagnosis of respiratory syncytial virus infection. J Clin Microbiol 1988;26:808-811
114. Blanco JCG, Boukhvalova MS, Hemming P, Ottolini M, Prince GA. Prospects of antiviral and anti-inflammatory therapy for respiratory syncytial virus infection. Expert Rev Anti Infect Ther 2005;3:945-955
115. Hall CB, McBride JT, Walsh EE, et al. Aerosolized ribavirin treatment of infants with respiratory syncytial viral infection. N Engl J Med 1983;308:1443-1447
116. Committee on Infectious Diseases. Reassessment of the indications for ribavirin therapy in respiratory syncytial virus infections. Pediatrics 1996;97:137-140
117. Committee on Infectious Diseases. Use of ribavirin in the treatment of respiratory syncytial virus infection. Pediatrics 1993;92:501-504
118. Randolph AG, Wang EEL. Ribavirin for respiratory syncytial virus lower respiratory tract infection. Arch Pediatr Adolesc Med 1996;150:942-947
119. Feldman RJ, Fidalgo HC, John JF Jr. Respiratory syncytial virus in a cardiac surgery intensive care unit. J Thorac Cardiovasc Surg 1994;108:1152
120. Takimoto CH, Cram DL, Root RK. Respiratory syncytial virus infections on an adult medical ward. Arch Intern Med 1991;151:706-708
121. Liss HP, Bernstein J. Ribavirin aerosol in the elderly. Chest 1988;93:1239-1241
122. Englund JA, Piedra PA, Ahn Y-M, Gilbert BE, Hiatt PW. High-dose, short-duration ribavirin aerosol therapy compared with standard ribavirin therapy in children with suspected respiratory syncytial virus infection. J Pediatr 1994;125:635-641
123. Hall CB, Douglas RG, Geiman JM. Respiratory syncytial virus infections in infants: quantitation and duration of shedding. J Pediatr 1976;89:11-15
124. Hall CB, Douglas RG. Modes of transmission of respiratory syncytial virus. J Pediatr 1981;99:100-103
125. Graman PS, Hall CB. Epidemiology and control of nosocomial viral infections. Infect Dis Clin North Am 1989;3:815-841
126. Madge P, Paton JY, McColl JH, Mackie PLK. Prospective controlled study of four infection-control procedures to prevent nosocomial infection with respiratory syncytial virus. Lancet 1992;340:1079-1083
127. Falsey AR, Criddle MM, Kolassa JE, McCann RM, Brower CA, Hall WJ. Evaluation of a handwashing intervention to reduce respiratory illness rates in senior day-care centers. Infect Control Hosp Epidemiol 1999;20:200-202
128. Falsey AR, Walsh EE. Safety and immunogenicity of a respiratory syncytial virus subunit vaccine (PFP-2) in ambulatory adults over age 60. Vaccine 1996;14:1214-1218
129. Falsey AR, Walsh EE. Safety and immunogenicity of a respiratory syncytial virus subunit vaccine (PFP-2) in the institutionalized elderly. Vaccine 1997;15:1130-1132
130. Gonzalez IM, Karron RA, Eichelberger M, et al. Evaluation of the live attenuated cpts 248/404 RSV vaccine in combination with a subunit RSV vaccine (PFP-2) in healthy young and older adults. Vaccine 2000;18:1763-1772