Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: Correlation between the platelet defect and the α-granule content in the patient and four relatives

Journal of Thrombosis and Haemostasis

Volumn 5, Issue 3, 2007, Pages 551-559

  De Candia, Erica ^a   Pecci, A ^b   Ciabattoni, G ^c   De Cristofaro, R ^a   Rutella, S ^a   Yao Wu, Z ^d   Lazzareschi, I ^a   Landolfi, R ^a   Coughlin, S ^d   Balduini, C L ^b  

^a FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Gray platelet syndrome; Platelet protease activated receptors; Platelet granules; Thrombin receptors; Thromboxane biosynthesis

Indexed keywords

PADGEM PROTEIN; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; THROMBOXANE B2; ALANYL TYROSYL PROLYL GLYCYL LYSYL PHENYLALANINE; ALANYL-TYROSYL-PROLYL-GLYCYL-LYSYL-PHENYLALANINE; COAGULATING AGENT; OLIGOPEPTIDE; PAR 1 ACTIVATING PEPTIDE; PAR-1-ACTIVATING PEPTIDE; THROMBOCYTE FACTOR 4; THROMBOSPONDIN 1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; BLOOD PROTEIN DISORDER; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL FEATURE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; GRAY THROMBOCYTE SYNDROME; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; MALE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; THROMBOCYTE AGGREGATION; THROMBOCYTE ANOMALY; THROMBOCYTE FUNCTION; THROMBOCYTE RELEASE REACTION; BLOOD; BLOOD CLOTTING PARAMETERS; CALCIUM SIGNALING; CASE REPORT; CELL GRANULE; DRUG EFFECT; DRUG POTENTIATION; FAMILY; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PEDIGREE; SYNDROME; THROMBOCYTE; THROMBOCYTE DISORDER; ULTRASTRUCTURE;

ADOLESCENT; ADULT; AGED; BLOOD PLATELETS; CALCIUM SIGNALING; COAGULANTS; CYTOPLASMIC GRANULES; FAMILY; FEMALE; HUMANS; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; OLIGOPEPTIDES; P-SELECTIN; PEDIGREE; PHENOTYPE; PLATELET AGGREGATION; PLATELET FACTOR 4; PLATELET FUNCTION TESTS; PLATELET STORAGE POOL DEFICIENCY; RECEPTOR, PAR-1; SYNDROME; THROMBIN; THROMBOSPONDIN 1; THROMBOXANE B2;

EID: 34247600608     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2007.02329.x     Document Type: Article

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