Abnormal N-glycosylation of the immunoglobulin G κ chain in a multiple myeloma patient with crystalglobulinemia: Case report

International Journal of Hematology

Volumn 85, Issue 3, 2007, Pages 203-206

  Hashimoto, Ryo ^a,c   Toda, Tosifusa ^b   Tsutsumi, Hisashi ^a   Ohta, Masatsugu ^a   Mori, Mayumi ^a  

^a Tokyo Metropolitan Institute of Gerontology   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c NONE   (Japan)

Author keywords

Abnormal glycosylation; Crystalglobulin; Immunoglobulin light chain; Multiple myeloma

Indexed keywords

DEXAMETHASONE; DODECYL SULFATE SODIUM; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MELPHALAN; PREDNISOLONE; RANIMUSTINE; THALIDOMIDE; VINDESINE;

ADULT; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER PATIENT; CASE REPORT; CRYSTALGLOBULINEMIA; CRYSTALLIZATION; GLYCOSYLATION; HOSPITALIZATION; HUMAN; KIDNEY FAILURE; LABORATORY TEST; MALE; MASS SPECTROMETRY; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PHYSICAL EXAMINATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; ROOM TEMPERATURE; SKIN ULCER;

CRYSTALLIZATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA-CHAINS; KIDNEY FAILURE; MALE; MIDDLE AGED; MULTIPLE MYELOMA; SKIN ULCER;

EID: 34247599369     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.06074     Document Type: Article

References (14)

1. Rengers JU, Touchard G, Decourt C, Deret S, Michel H, Cogne M. Heavy and light chain primary structures control IgG3 nephritogenicity in an experimental model for cryocrystalglobulinemia. Blood. 2000;95:3467-3472.
2. Simsek S, van den Haak RFF, Voskuyl AE, Rauwerda JA, Strack van Schijndel RJ. Symmetrical, painful ulceration of the lower limbs in a vascular surgery ward: a diagnostic challenge. Pyoderma gangrenosum associated with IgG-kappa paraproteinaemia. Neth J Med. 2004;62:168-171.
3. Ball NJ, Wickert W, Marx LH, Thaell JF. Crystalglobulinemia syndrome: a manifestation of multiple myeloma. Cancer. 1993;71:1231-1234.
4. Langlands DR, Dawkins RJ, Matz LR, et al. Arthritis associated with crystallizing cryoprecipitable IgG paraprotein. Am J Med. 1980;68:461-465.
5. Grossman J, Abraham GN, Leddy JP, Condemi JL. Crystalglobulinemia. Ann Intern Med. 1972;77:395-400.
6. Mills LE, Brettman LR, Jentoft JE, Viner ED. Crystallocryoglobulinemia resulting from human monoclonal antibodies to albumin. Ann Intern Med. 1983;99:601-604.
7. Cummings FJ, Park CH, Bogaars HA, et al. Successful therapy of crystalcryoglobulinemia: a case report. Med Pediatr Oncol. 1979;7:181-190.
8. Stone GC, Wall BA, Oppliger IR, et al. A vasculopathy with deposition of lambda light chain crystals. Ann Intern Med. 1989;110:275-278.
9. Dotten DA, Pruzanski W, Olin J, Brown TC. Crystalglobulinemia. Can Med Assoc. 1976;114:909-912.
10. Mullen B, Chalvardjian A. Crystalline tissue deposits in a case of multiple myeloma. Arch Pathol Lab Med. 1981;105:94-97.
11. Powell FC, Schroeter AL, Su WP, Perry HO. Pyoderma gangrenosum and monoclonal gammopathy. Arch Dermatol. 1983;119: 468-472.
12. Abraham GN, Leddy JP, Grossman J, Condemi JJ. Properties of crystalline IgG3 globulin. Biochem Biophys Res Commun. 1972;46:162-166.
13. Foss GS, Nilsen R, Cornwell GC 3rd, Husby G, Sletten K. A glycosylated Bence Jones protein and its autologous amyloid light chain containing potentially amyloidogenic residues. Scand J Immunol. 1998;47:348-354.
14. Omtvedt LA, Bailey D, Renouf DV, et al. Glycosylation of immunoglobulin light chains associated with amyloidosis. Amyloid. 2000;7:227-244.