Mutagenesis of a bacteriophage lytic enzyme PlyGBS significantly increases its antibacterial activity against group B streptococci

Applied Microbiology and Biotechnology

Volumn 74, Issue 6, 2007, Pages 1284-1291

  Cheng, Qi ^a   Fischetti, Vincent A ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Bacteriophage lytic enzymes; DNA mutagenesis; Group B streptococci (GBS); Intrapartum antibiotic prophylaxis; Streptococcus agalactiae

Indexed keywords

BACTERIOPHAGE LYTIC ENZYMES; DNA MUTAGENESIS; GROUP B STREPTOCOCCI (GBS); INTRAPARTUM ANTIBIOTIC PROPHYLAXIS; STREPTOCOCCUS AGALACTIAE;

ANTIBIOTICS; BACTERIOPHAGES; DNA; MUTAGENESIS; MUTAGENS; PHYSIOLOGICAL MODELS;

ENZYMES;

BACTERIAL ENZYME; BACTERIAL ENZYME PLYGBS; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; BACTERIOPHAGE; BACTERIUM; DNA; ENZYME ACTIVITY; MENINGITIS; MUTAGENICITY; WOMENS HEALTH;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIOPHAGE; COLONY FORMING UNIT; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; MOUSE; MUTAGENESIS; NONHUMAN; STREPTOCOCCUS AGALACTIAE;

ANIMALS; BACTERIOLYSIS; BACTERIOPHAGES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME STABILITY; FEMALE; MICE; MODELS, ANIMAL; MUTAGENESIS; MUTANT PROTEINS; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; SODIUM CHLORIDE; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS AGALACTIAE; VAGINA; VIRAL PROTEINS;

STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS SP. 'GROUP B';

EID: 34247598409     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-006-0771-1     Document Type: Article

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