Arsenic trioxide represses NF-κB activation and increases apoptosis in ATRA-treated APL cells

Annals of the New York Academy of Sciences

Volumn 1090, Issue , 2006, Pages 203-208

  Mathieu, Julie ^a   Besançon, Françoise ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

APL; Apoptosis; As2O3; ATRA; JNK; NF B

Indexed keywords

ARSENIC TRIOXIDE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RETINOIC ACID; STRESS ACTIVATED PROTEIN KINASE; ORGANOARSENIC DERIVATIVE; OXIDE;

APOPTOSIS; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA CELL; PROMYELOCYTIC LEUKEMIA; ARTICLE; DNA PROBE; DRUG EFFECT; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY;

APOPTOSIS; ARSENICALS; BASE SEQUENCE; DNA PROBES; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; NF-KAPPA B; OXIDES; TRETINOIN;

EID: 34247562264     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1378.022     Document Type: Conference Paper

References (10)

1. CASSINAT, B. & C. CHOMIENNE. 2001. Biological features of primary APL blasts: their relevance to the understanding of granulopoiesis, leukemogenesis and patient management. Oncogene 20: 7154-7160.
2. LARSON, R.S. & M.S. TALLMAN. 2003. Retinoic acid syndrome: manifestations, pathogenesis, and treatment. Best Pract. Res. Clin. Haematol. 16: 453-461.
3. MATHIEU, J., S. GIRAUDIER, M. LANOTTE & F. BESANCON. 2005. Retinoid-induced activation of NF-κB in APL cells is not essential for granulocytic differentiation, but prolongs the life span of mature cells. Oncogene 24: 7145-7155.
4. ZHU, J., Z. CHEN, V. LALLEMAND- BREITENBACH & H. DE THE. 2002. How acute promyelocytic leukemia revived arsenic. Nat. Rev. Cancer 2: 1-9.
5. MILLER, W.H., H.M. SCHIPPER, J.S. LEE, et al. 2002. Mechanisms of action of arsenic trioxide. Cancer Res. 62: 3893-3903.
6. LANOTTE, M., V. MARTIN-THOUVENIN, S. NAJMAN, et al. 1991. NB4, a maturation inductible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 77: 1080-1086.
7. HAYDEN, M.S. & S. GHOSH. 2004. Signaling to NF-kappa B. Genes Dev. 18: 2195-2224.
8. KAPAHI, P., T. TAKAHASHI, G. NATOLI, et al. 2000. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J. Biol. Chem. 275: 36062-36066.
9. MATHAS, S., A. LIETZ, M. JANZ, et al. 2003. Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis. Blood 102:1028-1034.
10. 3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 101: 5328-5335.