Mitomycin-C/5-fluorouracil/leucovorin and hyperfractionated radiation therapy for rectal carcinoma: A phase II study with long-term follow-up

Clinical Colorectal Cancer

Volumn 6, Issue 6, 2007, Pages 436-441

  Nabhan, Chadi ^a,b   Ragam, Avanthi ^a   Samuels, Brian ^a   Milton, Daniel T ^a   Prasad, Leela ^a   Hooberman, Arthur ^a   Hartsell, William ^a   Anthony, Andi ^a   Weisman, Robert ^a   Bitran, Jacob D ^a  

^a ADVOCATE LUTHERAN GENERAL HOSPITAL   (United States)

^b Lutheran General Cancer Center   (United States)

Author keywords

Adjuvant therapy; Chemotherapy; Downstaging; Survival

Indexed keywords

FLUOROURACIL; FOLINIC ACID; MITOMYCIN C;

ADULT; AGED; ALOPECIA; ANOREXIA; ARTICLE; BONE MARROW SUPPRESSION; CANCER ADJUVANT THERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; COLONOSCOPY; COMBINATION CHEMOTHERAPY; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG TOLERABILITY; FATIGUE; FEMALE; FEVER; FOLLOW UP; HUMAN; HUMAN TISSUE; INFECTION; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUROLOGIC DISEASE; NEUTROPENIA; OVERALL SURVIVAL; PAIN; PHASE 2 CLINICAL TRIAL; PHLEBITIS; PROCTITIS; RADIATION DOSE; RECTUM CARCINOMA; SIGMOIDOSCOPY; STOMATITIS; THROMBOCYTOPENIA; TREATMENT RESPONSE; VOMITING;

EID: 34247548380     PISSN: 15330028     EISSN: None     Source Type: Journal    
DOI: 10.3816/CCC.2007.n.013     Document Type: Article

References (28)

1. NIH Consensus Conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA 1990; 264: 1444-1450.
2. Minsky BD, Cohen AM, Kemeny N, et al. Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy. J Clin Oncol 1992; 10:79-84.
3. Wichmann MW, Muller C, Meyer G, et al. Effect of preoperative radiochemotherapy on lymph node retrieval after resection of rectal cancer. Arch Surg 2002; 137:206-210.
4. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004; 351:1731-1740.
5. Rodel C, Sauer R. Neoadjuvant radiochemotherapy in rectal cancer: for which patients and tumor stages? Front Radiat Ther Oncol 2004; 38:13-23.
6. Nelson H, Sargent DJ. Refining multimodal therapy for rectal cancer. N Engl J Med 2001; 345:690-692.
7. Bartelink H, Roelofsen F, Eschwege F, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 1997;15:2040-2049.
8. Flam M, John M, Pajak TF, et al. Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol 1996; 14:2527-2539.
9. Simon R. Optimal two-stage designs for phase II clinical trials. Control Clin Trials 1989; 10:1-10.
10. Douglass HO, Jr, Moertel CG, Mayer RJ, et al. Survival after postoperative combination treatment of rectal cancer. N Engl J Med 1986; 315:1294-1295.
11. Mohiuddin M, Winter K, Mitchell E, et al. Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group trial 0012. J Clin Oncol 2006; 24:650-655.
12. Chan AK, Wong AO, Langevin J, et al. Preoperative chemotherapy and pelvic radiation for tethered or fixed rectal cancer: a phase II dose escalation study. Int J Radiat Oncol 2000; 48:843-856.
13. Burke SJ, Percarpio BA, Knight DC, et al. Combined preoperative radiation and mitomycin/5-fluorouracil treatment for locally advanced rectal adenocarcinoma. J Am Coll Surg 1998; 187:164-170.
14. Stryker SJ, Kiel KD, Rademaker A, et al. Preoperative "chemoradiation" for stages II and III rectal carcinoma. Arch Surg 1996; 131:514-518.
15. Mohiuddin M, Hayne M, Regine WF, et al. Prognostic significance of postchemoradiation stage following preoperative chemotherapy and radiation for advanced/recurrent rectal cancers. Int J Radiat Oncol 2000; 48:1075-1080.
16. Rich TA, Skibber JM, Ajani JA, et al. Preoperative infusional chemoradiation therapy for stage T3 rectal cancer. Int J Radiat Oncol 1995; 32:1025-1029.
17. Kim JS, Kim JS, Cho MJ, et al. Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer. Int J Radiat Oncol 2002; 54:403-408.
18. Gerard JP, Chapet O, Nemoz C, et al. Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: the Lyon R0-04 phase II trial. J Clin Oncol 2003; 21:1119-1124.
19. Shivnani A, Small W, Stryker S. Preoperative chemoradiation in rectal cancer: correlation of tumor response with survival. Proc Am Soc Clin Oncol 2004; 24:82 (Abstract #247).
20. Diaz-Gonzalez JA, Calvo FA, Cortes J, et al. Preoperative chemoradiation with oral tegafur within a multidisciplinary therapeutic approach in patients with T3-4 rectal cancer. Int J Radiat Oncol 2005; 61:1378-1384.
21. Ceelen W, Pattyn P, Boterberg T, et al. Pre-operative combined modality therapy in the management of locally advanced rectal cancer. Eur J Surg Oncol 2006; 32:259-268.
22. Chau I, Brown G, Cunningham D, et al. Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer. J Clin Oncol 2006; 24:668-674.
23. Gerard JP, Chapet O, Nemoz C, et al. Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy: the Lyon R96-02 randomized trial. J Clin Oncol 2004; 22:2404-2409.
24. Machiels JP, Aydin S, Bonny MA, et al. What is the best way to predict disease-free survival after preoperative radiochemotherapy for rectal cancer patients: tumor regression grading, nodal status, or circumferential resection margin invasion? J Clin Oncol 2006; 24:1319.
25. Starzewski JJ, Pajak JT, Pawelczyk I, et al. The radiation-induced changes in rectal mucosa: hyperfractionated vs. hypofractionated preoperative radiation for rectal cancer. Int J Radiat Oncol 2006; 64:717-724.
26. Aschele C, Friso ML, Pucciarelli S, et al. A phase I-II study of weekly oxaliplatin, 5-fluorouracil continuous infusion and preoperative radiotherapy in locally advanced rectal cancer. Ann Oncol 2005; 16:1140-1146.
27. Glynne-Jones R, Sebag-Montefiore D, Maughan TS, et al. A phase I dose escalation study of continuous oral capecitabine in combination with oxaliplatin and pelvic radiation (XELOX-RT) in patients with locally advanced rectal cancer. Ann Oncol 2006; 17:50-56.
28. Meta-analysis Group in Cancer. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 1998; 16:301-308.