Combat veterans show normal discrimination during differential trace eyeblink conditioning, but increased responsivity to the conditioned and unconditioned stimulus

Journal of Psychiatric Research

Volumn 41, Issue 9, 2007, Pages 785-794

  Burriss, Louisa ^a,b   Ayers, Edwin ^a,c   Powell, D A ^a,b,d  

^a WJB Dorn VA Medical Center   (United States)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c SOUTH CAROLINA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Anxiety; Associative learning; Discrimination; Extinction; Medication; Somatomotor conditioning

Indexed keywords

ADULT; ARTICLE; CONDITIONED REFLEX; CONDITIONING; CONTROLLED STUDY; EYELID REFLEX; FEMALE; HUMAN; LEARNING DISORDER; MAJOR CLINICAL STUDY; MALE; PERCEPTIVE DISCRIMINATION; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; REINFORCEMENT; STATE DEPENDENT LEARNING; STIMULUS RESPONSE; VETERAN;

ACOUSTIC STIMULATION; AGED; ANALYSIS OF VARIANCE; BLINKING; CHI-SQUARE DISTRIBUTION; CONDITIONING, CLASSICAL; DISCRIMINATION (PSYCHOLOGY); ELECTROMYOGRAPHY; EXTINCTION, PSYCHOLOGICAL; FEMALE; HUMANS; MALE; MIDDLE AGED; PSYCHOMETRICS; REACTION TIME; STRESS DISORDERS, POST-TRAUMATIC; VETERANS;

EID: 34247538028     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2006.04.004     Document Type: Article

References (33)

1. Ayers E.D., and Powell D.A. Multiple response measures during classical conditioning. Journal of Neuroscience Methods 114 (2002) 33-38
2. Ayers E.D., White J., and Powell D.A. Pavlovian eyeblink conditioning in combat veterans with and without post-traumatic stress disorder. Integrative Physiological and Behavioral Science 38 (2003) 230-247
3. Blake D.D., Weathers F.W., Nagy L.M., Kaloupek D.G., Gusman F.D., Charney D.S., et al. The development of a clinician-administered PTSD scale. Journal of Traumatic Stress 8 (1995) 75-90
4. Bremner J.D., Krystal J.H., Southwick S.M., and Charney D.S. Functional neuroanatomical correlates of the effects of stress on memory. Journal of Traumatic Stress 8 (1995) 527-553
5. Buchanan S.L., and Powell D.A. Divergencies in pavlovian conditioned heart rate and eyeblink responses produced by hippocampectomy in the rabbit. Behavioral and Neural Biology 30 (1980) 20-38
6. Buchanan S.L., and Powell D.A. Hippocampal lesions and Pavlovian cardiovascular conditioning. Pavlovian Journal of Biological Science 17 (1982) 158-164
7. Chachich M., and Powell D.A. Both medial prefrontal and amygdala central nucleus lesions abolish heart rate classical conditioning, but only prefrontal lesions impair reversal of eyeblink differential conditioning. Neuroscience Letters 257 (1999) 151-154
8. Clark R.E., and Squire L.R. Classical conditioning and brain systems: the role of awareness. Science 280 (1998) 77-81
9. Daum I., Channon S., and Gray J.A. Classical conditioning after temporal lobe lesions in man: sparing of simple discrimination and extinction. Behavioural Brain Research 52 (1992) 159-165
10. Davis M. The role of the amygdala in conditioned fear. In: Aggleton J.P. (Ed). The amygdala: neurobiological aspects of emotion, memory, and mental dysfunction (1992), Wiley-Liss, Inc., New York (NY) 255-305
11. Gabrieli J.D.E., McGlinchey-Berroth R., Carrillo M.C., Gluck M.A., Cermak L.S., and Disterhoft J.F. Intact delay-eyeblink classical conditioning in amnesia. Behavioral Neuroscience 109 (1995) 819-827
12. Greenhouse S.W., and Geisser S. On methods in the analysis of profile data. Psychometrika 24 (1959) 95-112
13. Grillon C., and Morgan C.A. Fear-potentiated startle conditioning to explicit and contextual cues in Gulf War veterans with posttraumatic stress disorder. Journal of Abnormal Psychology 108 (1999) 134-142
14. Jarrell T.W., Gentile C.G., Romanski L.M., McCabe P.M., and Schneiderman N. Involvement of cortical and thalamic auditory regions in retention of differential bradycardiac conditioning to acoustic conditioned stimuli in rabbits. Brain Research 412 (1987) 285-294
15. Keane T.M., Caddell J.M., and Taylor K.L. Mississippi Scale for combat-related posttraumatic stress disorder: three studies in reliability and validity. Journal of Consulting and Clinical Psychology 56 (1988) 85-90
16. Keane T.M., Fairbank J.A., Caddell J.M., Zimering R.T., Taylor K.L., and Mora C.A. Clinical evaluation of a measure to assess combat exposure. Psychological Assessment 1 (1989) 53-55
17. Lavond D.G., Lincoln J.S., McCormick D.A., and Thompson R.F. Effect of bilateral lesions of the dentate and interpositus cerebellar nuclei on conditioning of heart-rate and nictitating membrane/eyelid responses in the rabbit. Brain Research 305 (1984) 323-330
18. LeDoux J. Fear and the brain: where have we been, and where are we going?. Biological Psychiatry 44 (1998) 1229-1238
19. McLaughlin J., Skaggs H., Churchwell J., and Powell D.A. Medial prefrontal cortex and Pavlovian conditioning: trace versus delay conditioning. Behavioral Neuroscience 116 (2002) 37-47
20. Moyer Jr. J.R., Deyo R.A., and Disterhoft J.F. Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behavioral Neuroscience 104 (1990) 243-252
21. Orr S.P., Metzger L.J., Lasko N.B., Macklin M.L., Peri T., and Pitman R.K. De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. Journal of Abnormal Psychology 109 (2000) 290-298
22. Peri T., Ben-Shakhar G., Orr S.P., and Shalev A.Y. Psychophysiologic assessment of aversive conditioning in posttraumatic stress disorder. Biological Psychiatry 47 (2000) 512-519
23. Powell D.A. A behavioral stages model of classical (Pavlovian) conditioning: application to cognitive aging. Neuroscience and Biobehavioral Reviews 23 (1999) 797-816
24. Powell D.A., and Buchanan S.L. Autonomic-somatic relationships in the rabbit (oryctolagus cuniculus): effects of hippocampal lesions. Physiological Psychology 8 (1980) 455-462
25. Powell D.A., McLaughlin J., and Chachich M. Classical conditioning of autonomic and somatomotor responses and their central nervous system substrates. In: Steinmetz J.E., and Woodruff-Pak D.S. (Eds). Eyeblink classical conditioning. Animal models vol. 2 (2000), Kluwer Academic Publishers, Boston (MA) 257-286
26. Powell D.A., Watson K., and Maxwell B. Involvement of subdivisions of the medial prefrontal cortex in learned cardiac adjustments. Behavioral Neuroscience 108 (1994) 294-307
27. Solomon P.R., and Moore J.W. Latent inhibition and stimulus generalization of the classically conditioned nictitating membrane response in rabbits (oryctolagus cuniculus) following dorsal hippocampal ablation. Journal of Comparative and Physiological Psychology 89 (1975) 1192-1203
28. Spielberger C.D. State-trait anxiety inventory (1983), Consulting Psychologists Press, Inc
29. Thompson R.F. In search of memory traces. Annual Review of Psychology 56 (2005) 1-23
30. Vasterling J.J., Brailey K., Constans J.I., and Sutker P.B. Attention and memory dysfunction in posttraumatic stress disorder. Neuropsychology 12 (1998) 125-133
31. Weible A.P., McEchron M.D., and Disterhoft J.F. Cortical involvement in acquisition and extinction of trace eyeblink conditioning. Behavioral Neuroscience 114 (2000) 1058-1067
32. Weiss C., and Disterhoft J.F. Eyeblink conditioning, motor control, and the analysis of limbic-cerebellar interactions. Behavioral and Brain Sciences 19 (1996) 479-527
33. Zung W.W.K. A self rating depression scale. Archives in General Psychiatry 12 (1965) 63-70