Pyrazolo[1,5-a]pyridine antiherpetics: Effects of the C3 substituent on antiviral activity

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 10, 2007, Pages 2858-2862

  Johns, Brian A ^a   Gudmundsson, Kristjan S ^a   Allen, Scott H ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Herpes; HSV; Pyrazolo 1,5 a pyridine

Indexed keywords

PYRAZOLO[1,5 A]PYRIDINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; HERPES VIRUS; PH; PHARMACOPHORE; VIRUS REPLICATION;

ANTIVIRAL AGENTS; HERPESVIRIDAE; HUMANS; PYRAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HERPES; HERPESVIRIDAE; SIMPLEXVIRUS;

EID: 34247532781     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.058     Document Type: Article

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9. 3SnCl.
10. 3 and acidic workup.
11. The structure of 21 was confirmed by X-ray.
12. Interestingly, 2-substituted dihydro intermediate 21 did not undergo the aromatization step when subjected to the same conditions as its 4-substituted counterpart, 20.