Sodium Iodide Symporter Is Expressed at the Preneoplastic Stages of Liver Carcinogenesis and in Human Cholangiocarcinoma

Gastroenterology

Volumn 132, Issue 4, 2007, Pages 1495-1503

  Liu, Bingkai ^a,b   Hervé, Julie ^a,b   Bioulac Sage, Paulette ^c   Valogne, Yannick ^a,b   Roux, Jérôme ^d   Yilmaz, Funda ^a,b,e   Boisgard, Raphaël ^e   Guettier, Catherine ^a,b   Calès, Paul ^d   Tavitian, Bertrand ^e   Samuel, Didier ^a,b   Clerc, Jérôme ^a   Bréchot, Christian ^a,b   Faivre, Jamila ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c HÔPITAL PELLEGRIN   (France)

^d UNIVERSITÉ D'ANGERS   (France)

^e INSERM ^*  (France)

Author keywords

CCA; cholangiocarcinoma; DEN; diethylnitrosamine; HCC; hepatocellular carcinoma; IHC; immunohistochemistry; NIS; regions of interest; reverse transcription polymerase chain reaction; ROI; RT PCR; single photon emission computed tomography coupled with high powered computerized tomography; sodium iodide symporter; SPECT CT

Indexed keywords

DIETHYLNITROSAMINE; IODINE 131; MESSENGER RNA; PROTEIN; SODIUM IODIDE SYMPORTER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILE DUCT CARCINOMA; CANCER RADIOTHERAPY; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID CANCER; THYROID CELL;

EID: 34247530789     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.01.044     Document Type: Article

References (22)

1. Dai G., Levy O., and Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature 379 (1996) 458-460
2. Knostman K.A., Cho J.Y., Ryu K.Y., Lin X., McCubrey J.A., Hla T., Liu C.H., Di Carlo E., Keri R., Zhang M., Hwang D.Y., Kisseberth W.C., Capen C.C., and Jhiang S.M. Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer. J Clin Endocrinol Metab 89 (2004) 5196-5203
3. Kogai T., Kanamoto Y., Che L.H., Taki K., Moatamed F., Schultz J.J., and Brent G.A. Systemic retinoic acid treatment induces sodium/iodide symporter expression and radioiodide uptake in mouse breast cancer models. Cancer Res 64 (2004) 415-422
4. Spitzweg C., Joba W., Eisenmenger W., and Heufelder A.E. Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa. J Clin Endocrinol Metab 83 (1998) 1746-1751
5. Spitzweg C., Joba W., Schriever K., Goellner J.R., Morris J.C., and Heufelder A.E. Analysis of human sodium iodide symporter immunoreactivity in human exocrine glands. J Clin Endocrinol Metab 84 (1999) 4178-4184
6. Tazebay U.H., Wapnir I.L., Levy O., Dohan O., Zuckier L.S., Zhao Q.H., Deng H.F., Amenta P.S., Fineberg S., Pestell R.G., and Carrasco N. The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nat Med 6 (2000) 871-878
7. Wapnir I.L., van de Rijn M., Nowels K., Amenta P.S., Walton K., Montgomery K., Greco R.S., Dohan O., and Carrasco N. Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections. J Clin Endocrinol Metab 88 (2003) 1880-1888
8. Upadhyay G., Singh R., Agarwal G., Mishra S.K., Pal L., Pradhan P.K., Das B.K., and Godbole M.M. Functional expression of sodium iodide symporter (NIS) in human breast cancer tissue. Breast Cancer Res Treat 77 (2003) 157-165
9. Wapnir I.L., Goris M., Yudd A., Dohan O., Adelman D., Nowels K., and Carrasco N. The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid. Clin Cancer Res 10 (2004) 4294-4302
10. Dentice M., Luongo C., Elefante A., Romino R., Ambrosio R., Vitale M., Rossi G., Fenzi G., and Salvatore D. Transcription factor Nkx-2.5 induces sodium/iodide symporter gene expression and participates in retinoic acid- and lactation-induced transcription in mammary cells. Mol Cell Biol 24 (2004) 7863-7877
11. Levy O., De la Vieja A., Ginter C.S., Riedel C., Dai G., and Carrasco N. N-linked glycosylation of the thyroid Na+/I-symporter (NIS). Implications for its secondary structure model. J Biol Chem 273 (1998) 22657-22663
12. Faivre J., Clerc J., Gerolami R., Herve J., Longuet M., Liu B., Roux J., Moal F., Perricaudet M., and Brechot C. Long-term radioiodine retention and regression of liver cancer after sodium iodide symporter gene transfer in Wistar rats. Cancer Res 64 (2004) 8045-8051
13. 131I therapy. Lancet 2 (1976) 73-75
14. Sirica A.E. Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy. Hepatology 41 (2005) 5-15
15. Malhi H., and Gores G.J. Review article: the modern diagnosis and therapy of cholangiocarcinoma. Aliment Pharmacol Ther 23 (2006) 1287-1296
16. Lazaridis K.N., and Gores G.J. Cholangiocarcinoma. Gastroenterology 128 (2005) 1655-1667
17. Khan S.A., Thomas H.C., Davidson B.R., and Taylor-Robinson S.D. Cholangiocarcinoma. Lancet 366 (2005) 1303-1314
18. Gores G.J., Baskin-Bey E.S., Baron T.H., and Alberts S.R. Treatment endpoints for advanced cholangiocarcinoma. Nat Clin Pract Gastroenterol Hepatol 1 (2004) 4-5
19. Daniels G.H., and Haber D.A. Will radioiodine be useful in treatment of breast cancer?. Nat Med 6 (2000) 859-860
20. Mandell R.B., Mandell L.Z., and Link Jr. C.J. Radioisotope concentrator gene therapy using the sodium/iodide symporter gene. Cancer Res 59 (1999) 661-668
21. Haberkorn U., Kinscherf R., Kissel M., Kubler W., Mahmut M., Sieger S., Eisenhut M., Peschke P., and Altmann A. Enhanced iodide transport after transfer of the human sodium iodide symporter gene is associated with lack of retention and low absorbed dose. Gene Ther 10 (2003) 774-780
22. Sell S. Cellular origin of hepatocellular carcinomas. Semin Cell Dev Biol 13 (2002) 419-424