Relationship Between Opioid Therapy, Tissue-Damaging Procedures, and Brain Metabolites as Measured by Proton MRS in Asphyxiated Term Neonates

Pediatric Research

Volumn 61, Issue 5, 2007, Pages 614-621

  Angeles, Danilyn M ^a   Ashwal, Stephen ^a   Wycliffe, Nathaniel D ^a   Ebner, Charlotte ^a   Fayard, Elba ^a   Sowers, Lawrence ^a   Holshouser, Barbara A ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; CREATINE; FENTANYL; GLUTAMIC ACID; GLUTAMINE; INOSITOL; LACTIC ACID; MORPHINE; N ACETYLASPARTIC ACID; OPIATE;

ARTERY CATHETERIZATION; ARTICLE; BASAL GANGLION; BRAIN INJURY; BRAIN METABOLISM; CATHETERIZATION; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG INTERMITTENT THERAPY; ENDOTRACHEAL INTUBATION; FEMALE; GRAY MATTER; HUMAN; INCIDENCE; INJECTION; INTUBATION; LUMBAR PUNCTURE; MALE; MEDICAL RECORD REVIEW; METABOLITE; NEUROPROTECTION; NEWBORN; NEWBORN INTENSIVE CARE; NEWBORN PERIOD; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL LOBE; PAIN; PERINATAL ASPHYXIA; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REPEAT PROCEDURE; STOMACH INTUBATION; STRESS; SUCTION; THALAMUS; TISSUE INJURY; TRACHEA; VEIN CATHETERIZATION; VEIN PUNCTURE;

ANALGESICS, OPIOID; ASPHYXIA NEONATORUM; BRAIN; FEMALE; HUMANS; INFANT, NEWBORN; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; STATISTICS; TREATMENT OUTCOME;

EID: 34247526278     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/pdr.0b013e318045bde9     Document Type: Article

References (31)

1. Shalak L, Perlman JM 2004 Hypoxic-ischemic brain injury in the term infant-current concepts. Early Hum Dev 80:125-141.
2. Cady EB 2001 Magnetic resonance spectroscopy in neonatal hypoxic-ischaemic insults. Childs Nerv Syst 17:145-149.
3. Rutherford M 2002 MRI of the Neonatal Brain. WB Saunders, London, pp 295-308.
4. Angeles DM, Wycliffe N, Michelson D, Holshouser BA, Deming DD, Pearce WJ, Sowers LC, Ashwal S 2005 Use of opioids in asphyxiated term neonates: effects on neuroimaging and clinical outcome. Pediatr Res 57:873-878.
5. Dempsey EM, Al Hazzani F, Faucher D, Barrington KJ 2006 Facilitation of neonatal endotracheal intubation with mivacurium and fentanyl in the neonatal intensive care unit. Arch Dis Child Fetal Neonatal Ed 91:F279-F282.
6. Anand KJ, Scalzo FM 2000 Can adverse neonatal experiences alter brain development and subsequent behavior? Biol Neonate 77:69-82.
7. Porter FL, Wolf CM, Miller JP 1999 Procedural pain in newborn infants: the influence of intensity and development. Pediatrics 104:e13.
8. Lorek A, Takei Y, Cady EB, Wyatt JS, Penrice J, Edwards AD, Peebles D, Wylezinska M, Owen-Reece H, Kirkbride V, et al 1994 Delayed (“secondary”) cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res 36:699-706.
9. Azzopardi D, Wyatt JS, Cady EB, Delpy DT, Baudin J, Stewart AL, Hope PL, Hamilton PA, Reynolds EO 1989 Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr Res 25:445-451.
10. Barkovich AJ, Hajnal BL, Vigneron D, Sola A, Partridge JC, Allen F, Ferriero DM 1998 Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems 1998. AJNR Am J Neuroradiol 19:143-149.
11. Pu Y, Li QF, Zeng CM, Gao J, Qi J, Luo DX, Mahankali S, Fox PT, Gao JH 2000 Increased detectability of alpha brain glutamate/glutamine in neonatal hypoxic-ischemic encephalopathy. AJNR Am J Neuroradiol 21:203-212.
12. Provencher SW 1993 Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30:672-679.
13. Ashwal S, Holshouser B, Tong K, Serna T, Osterdock R, Gross M, Kido D 2004 Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury. J Neurotrauma 21:1539-1552.
14. Ashwal S, Holshouser BA, Tomasi LG, Shu S, Perkin RM, Nystrom GA, Hinshaw DB Jr 1997 1H-magnetic resonance spectroscopy-determined cerebral lactate and poor neurological outcomes in children with central nervous system disease. Ann Neurol 41:470-481.
15. Fiser DH 1992 Assessing the outcome of pediatric intensive care. J Pediatr 121:68-74.
16. Fiser DH, Long N, Roberson PK, Hefley G, Zolten K, Brodie-Fowler M 2000 Relationship of pediatric overall performance category and pediatric cerebral performance category scores at pediatric intensive care unit discharge with outcome measures collected at hospital discharge and 1- and 6-month follow-up assessments. Crit Care Med 28:2616-2620.
17. Shu SK, Ashwal S, Holshouser BA, Nystrom G, Hinshaw DB Jr 1997 Prognostic value of 1H-MRS in perinatal CNS insults. Pediatr Neurol 17:309-318.
18. Barkovich AJ, Baranski K, Vigneron D, Partridge JC, Hallam DK, Hajnal BL, Ferriero DM 1999 Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. AJNR Am J Neuroradiol 20:1399-1405.
19. Pattany PM, Yezierski RP, Widerstrom-Noga EG, Bowen BC, Martinez-Arizala A, Garcia BR, Quencer RM 2002 Proton magnetic resonance spectroscopy of the thalamus in patients with chronic neuropathic pain after spinal cord injury. AJNR Am J Neuroradiol 23:901-905.
20. Robertson NJ, Lewis RH, Cowan FM, Allsop JM, Counsell SJ, Edwards AD, Cox IJ 2001 Early increases in brain myo-inositol measured by proton magnetic resonance spectroscopy in term infants with neonatal encephalopathy. Pediatr Res 50:692-700.
21. Kreis R, Arcinue E, Ernst T, Shonk T, Flores R, Ross B 1996 Hypoxic encephalopathy after near-drowning studied by quantitative 1H-magnetic resonance spectroscopy. J Clin Invest 97:1142-1154.
22. Roelants-Van Rijn AM, Van Der Grond J, De Vries L, Groenendaal F 2001 Value of 1HMRS using different echo times in neonates with cerebral hypoxia-ischemia. Pediatr Res 49:356-362.
23. Pellerin L, Pellegri G, Bittar P, Charnay Y, Bouras C, Martin J, Stella N, Magistretti P 1998 Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev Neurosci 20:291-299.
24. Groenendaal F, Roelants-Van Rijn AM, van Der Grond J, Toet MC, de Vries LS 2001 Glutamate in cerebral tissue of asphyxiated neonates during the first week of life demonstrated in vivo using proton magnetic resonance spectroscopy. Biol Neonate 79:254-257.
25. Wang H, Gracy KN, Pickel VM 1999 Mu-opioid and NMDA-type glutamate receptors are often colocalized in spiny neurons within patches of the caudate-putamen nucleus. J Comp Neurol 412:132-146.
26. Ocana M, Cendan CM, Cobos EJ, Entrena JM, Baeyens JM 2004 Potassium channels and pain: present realities and future opportunities. Eur J Pharmacol 500:203-219.
27. Su CF, Liu MY, Lin MT 1987 Intraventricular morphine produces pain relief, hypothermia, hyperglycaemia and increased prolactin and growth hormone levels in patients with cancer pain. J Neurol 235:105-108.
28. Adler MW, Geller EB, Rosow CE, Cochin J 1988 The opioid system and temperature regulation. Annu Rev Pharmacol Toxicol 28:429-449.
29. McPherson BC, Yao Z 2001 Signal transduction of opioid-induced cardioprotection in ischemia-reperfusion. Anesthesiology 94:1082-1088.
30. Peart JN, Gross ER, Gross GJ 2005 Opioid-induced preconditioning: recent advances and future perspectives. Vascul Pharmacol 42:211-218.
31. Barry U, Zuo Z 2005 Opioids: old drugs for potential new applications. Curr Pharm Des 11:1343-1350.