Carotid plaque inflammation detected by 18F-fluorodeoxyglucose-positron emission tomography. Pilot study

Clinical Neurology and Neurosurgery

Volumn 109, Issue 5, 2007, Pages 409-412

  Arauz, Antonio ^a   Hoyos, Leticia ^a   Zenteno, Marco ^a   Mendoza, Raul ^b   Alexanderson, Erik ^b  

^a NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

^b Unidad PET Universidad Nacional Autónoma de México   (Mexico)

Author keywords

Atherosclerosis; Carotid plaque inflammation; PET

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; FLUORODEOXYGLUCOSE F 18;

ADULT; AGED; ARTICLE; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERIOGRAPHY; CAROTID ARTERY OBSTRUCTION; CAROTID ENDARTERECTOMY; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CONTROLLED STUDY; FATALITY; FEMALE; FOLLOW UP; HUMAN; HYPOTHESIS; IN VIVO STUDY; INTERNAL CAROTID ARTERY; MALE; PHYSICIAN; PILOT STUDY; POSITRON EMISSION TOMOGRAPHY; RESTENOSIS; STENT; TRANSIENT ISCHEMIC ATTACK; TREATMENT RESPONSE;

AGED; AGED, 80 AND OVER; ANGIOGRAPHY; CAROTID STENOSIS; CEREBRAL INFARCTION; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; INFLAMMATION; ISCHEMIC ATTACK, TRANSIENT; MALE; MIDDLE AGED; NEUROLOGIC EXAMINATION; PILOT PROJECTS; POSITRON-EMISSION TOMOGRAPHY; PROGNOSIS; RISK FACTORS;

EID: 34247523791     PISSN: 03038467     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clineuro.2007.02.012     Document Type: Article

References (15)

1. Jander S., Sitzer M., Schumann R., Schroeter M., Siebler M., Steinmetz H., et al. Inflammation in high-grade carotid stenosis: a possible role for macrophages and T cells in plaque destabilization. Stroke 29 (1998) 1625-1630
2. Ross R. Atherosclersosis: an inflammatory disease. N Engl J Med 340 (1999) 115-126
3. Rudd J.H.F., Warburton E.A., Fryer T.D., Jones H.A., Clark J.C., Antoun N., et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose-positron emission tomography. Circulation 105 (2002) 2708-2711
4. Davies J.R., Rudd J.H.F., Fryer T.D., Graves M.J., Clark J.C., Kikpatrick P.J., et al. Identification of culprit lesions after transient ischemic attack by combined 18 F Flurodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging. Stroke 36 (2005) 2642-2647
5. Ogawa M., Ishino S., Mukai T., Asano D., Teramoto N., Watabe H., et al. (18) FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study. J Nucl Med 45 (2004) 1245-1250
6. NASCET Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 325 (1991) 445-453
7. Wolf P.A., Clagett G.P., Easton J.D., Goldstein L.B., Gorelick P.B., Kelly-Hayes M., et al. Preventing ischemic stroke in patients with prior stroke and transient ischemic attack: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke 30 (1999) 1991-1994
8. Mazziotta J.C., Phelps M.E., Plummer D., and Kuhl D.E. Quantitation in positron emission computed tomography: 5. Physical-anatomical effects. J Comput Assist Tomogr 5 (1981) 734-743
9. Meikle S.R., Bailey D.L., and Hooper P.K. Simultaneous emission and transmission measurements for attenuation correction in whole body PET. J Nucl Med 36 (1995) 1680-1688
10. Davies M.J. Stability and instability: two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995. Circulation 94 (1996) 2013-2020
11. Hulthe J., Wikstrand J., and Emmanuelsson H. Atherosclerotic changes in the carotid artery bulb as measured by B-mode ultrasound are associated with the extent of coronary atherosclerosis. Stroke 28 (1997) 1189-1194
12. Crisby M., Nordin-Fredriksson G., and Shah P.K. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinsases, and cell death in human carotid plaques: implications for plaque stabilization. Circulation 103 (2001) 926-933
13. Tahara N., Kai T., Ishibashi M., Nakaura H., Kaida H., Baba K., et al. Simvastatin attenuates plaque inflammation. J Am Coll Cardiol 48 (2006) 1825-1831
14. Sugawara Y., Braun D.K., and Kison P.V. Rapid detection of human infections with fluorine-18 fluorodeoxyglucose and positron emission tomography: preliminary results. Eur J Nucl Med 25 (1998) 1238-1243
15. Tawakol A., Migrino R., Bashian G., Bedri S., Vermylen D., Cury R., et al. In vivo 18F-fluorodeoxyglucose-positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol 48 (2006) 1818-1824