Cardiac myosin-binding protein C in the heart

Archives des Maladies du Coeur et des Vaisseaux

Volumn 100, Issue 3, 2007, Pages 238-243

  Carrier, Lucie ^a,b,c  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b INSERM   (France)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

Cardiomyopathy; Contraction; Hypertrophy; Sarcomere

Indexed keywords

MYOSIN BINDING PROTEIN C;

CARDIOVASCULAR RISK; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; GENE MUTATION; HUMAN; NONHUMAN; PATHOGENESIS; PREVALENCE; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW;

CARDIOMYOPATHY, HYPERTROPHIC; CARRIER PROTEINS; HEART; HUMANS; MUTATION; MYOCARDIUM; MYOSINS; PHOSPHORYLATION;

EID: 34247519733     PISSN: 00039683     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (57)

1. Richard P, Charron P, Carrier L, et al. Hypertrophic Cardiomyopathy: distribution of disease genes, spectrum of mutations and implications for molecular diagnosis strategy. Circulation 2003;107:2227-32.
2. Starr R, Offer G. Polypeptide chains of intermediate molecular weight in myosin preparations. FEBS Lett 1971;15:40-4.
3. Offer G, Moos C, Starr R. A new protein of the thick filaments of vertebrate skeletal myofibrils: extraction, purification and characterization. J Mol Biol 1973;74:653-76.
4. Reinach FC, Masaki T, Shafiq S, Obinata T, Fishman DA. Isoforms of C-protein in adult chicken skeletal muscle: detection with monoclonal antibodies. J Cell Biol 1982;95:78-84.
5. Freiburg A, Gautel M. A molecular map of the interactions between titin and myosin-binding protein C. Implications for sarcomeric assembly in familial hypertrophic cardiomyopathy. Eur J Biochem 1996;235:317-26.
6. Alyonycheva TN, Mikawa T, Reinach FC, Fischman DA. Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain. J Biol Chem 1997;272:20866-72.
7. Flavigny J, Robert P, Camelin J, Schwartz K, Carrier L, Berebbi-Bertrand I. Biomolecular interactions between human recombinant b-MyHC and cMyBP-Cs implicated in familial hypertrophic cardiomyopathy. Cardiovasc Res 2003;60:388-96.
8. Kulikovskaya I, McCLellan G, Flavigny J, Carrier L, Winegrad S. Effect of MyBP-C binding to actin on contractility in heart muscle. J Gen Physiol 2003;122:1-15.
9. Fougerousse F, Delezoide AL, Fiszman MY, Schwartz K, Beckmann JS, Carrier L. Cardiac myosin binding protein C gene is specifically expressed in heart during murine and human development. Circ Res 1998;82:130-3.
10. Gautel M, Fürst DO, Cocco A, Schiaffino S. Isoform transitions of the myosin-binding protein C family in developing human and mouse muscles. Lack of isoform transcomplementation in cardiac muscle. Circ Res 1998;82:124-9.
11. Gilbert R, Kelly MG, Mikawa T, Fischman DA. The carboxyl terminus of myosin binding protein C (MyBP-C, C protein) specifies incorporation into A-band of striated muscle. J Cell Science 1996;109:101-11.
12. Okagaki T, Weber FE, Fischman DA, Vaughan KT, Mikawa T, Reinach FC. The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif. J Cell Biol 1993;123:619-26.
13. Starr R, Offer G. The interaction of C-protein with heavy meromyosin and subfragment-2. Biochem J 1978;171:813-6.
14. Koretz JF. Effects of C-protein on synthetic myosin filament structure. Biophys J 1979;27:433-6.
15. Seiler SH, Fischman DA, Leinwand LA. Modulation of myosin filament organization by C-protein family members. Mol Biol Cell 1996;7:113-27.
16. Vignier N, Perrot A, Schulte HD, et al. Cardiac myosin-binding protein C and familial hypertrophic cardiomyopathy: from mutations identification to human endomyocardial proteins analysis. Circulation 2001;104 (suppl.):II-1.
17. Herron TJ, Rostkova E, Kunst G, Chaturvedi R, Gautel M, Kentish JC. Activation of myocardial contraction by the N-terminal domains of myosin binding protein-C. Circ Res 2006;98:1290-8.
18. Gautel M, Zuffardi O, Freiburg A, Labeit S. Phosphorylation switches specific for the cardiac isoform of myosin binding protein C: a modulator of cardiac contraction? EMBO J 1995;14:1952-60.
19. Moolman-Smook J, Flashman E, de Lange W, et al. Identification of novel interactions between domains of myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations. Circ Res 2002;91:704-11.
20. Jeacocke S, England P. Phosphorylation of a myofibrillar protein of Mr 150,000 in perfused rat heart, and the tentative identification of this as C-protein. FEBS Lett 1980;122:129-32.
21. Hartzell HC, Glass DB. Phosphorylation of purified cardiac muscle C-protein by purified cAMP-dependent and endogenous Ca2+-calmodulin-dependent protein kinases. J Biol Chem 1984;259:15587-96.
22. Schlender KK, Bean LJ. Phosphorylation of chicken cardiac C-protein by calcium/calmodulin-dependent protein kinase II. J Biol Chem 1991;266:2811-7.
23. McClellan G, Kulikovskaya I, Winegrad S. Changes in cardiac contractility related to calcium-mediated changes in phosphorylation of myosin-binding protein C. Biophys J 2001;81:1083-92.
24. Levine R, Weisberg A, Kulikovskaya I, McClellan G, Winegrad S. Multiple structures of thick filaments in resting cardiac muscle and their influence on cross-bridge interactions. Biophys J 2001;81:1070-82.
25. Gruen M, Prinz H, Gautel M. cAPK-phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein C with myosin-S2 in an on-off fashion. FEBS Lett 1999;453:254-9.
26. Kunst G, Kress KR, Gruen M, Uttenweiler D, Gautel M, Fink RHA. Myosin binding protein C, a phosphorylation-dependent force regulator in muscle that controls the attachment or myosin heads by its interaction with myosin S2. Circ Res 2000;86:51-8.
27. Yamamoto K, Moos C. The C-proteins of rabbit red, white and cardiac muscles. J Biol Chem 1983;258:8395-401.
28. Hartzell HC. Effects of phosphorylated and unphosphorylated C-protein on cardiac actomyosin ATPase. J Mol Biol 1985;186:185-95.
29. Bartel S, Stein B, Eschenhagen T, et al. Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts. Mol Cell Biochem 1996;157:171-9.
30. 2+ handling in human chronic atrial fibrillation. Circulation 2006;114:670-80.
31. Decker RS, Decker ML, Kulikovskaya I, et al. Myosin-binding protein C phosphorylation, myofibril structure, and contractile function during low-flow ischemia. Circulation 2005;111:906-12.
32. Sadayappan S, Osinska H, Klevitsky R, et al. Cardiac myosin binding protein c phosphorylation is cardioprotective. Proc Natl Acad Sci U S A 2006;103:16918-23.
33. 2+ activation. J Physiol 1991;439:701-15.
34. Korte FS, McDonald KS, Harris SP, Moss RL. Loaded shortening, power output, and rate of force redevelopment are increasea with knockout of cardiac myosin binding protein-C. Circ Res 2003;93:752-8.
35. Stelzer JE, Dunning SB, Moss RL. Ablation of cardiac myosin-binding protein-C accelerates stretch activation in murine skinned myocardium. Circ Res 2006;98:1212-8.
36. Harris SP, Bartley CR, Hacker TA, et al. Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice. Circ Res 2002;90:594-601.
37. Carrier L, Knoll R, Vignier N, et al. Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice. Cardiovasc Res 2004;63:293-304.
38. Cazorla O, Szilagyi S, Vignier N, et al. Length and protein kinase A modulations of myocytes in cardiac myosin binding protein C-deficient mice. Cardiovasc Res 2006;69:370-80.
39. 2+ sensitive tension due to partial extraction of C-protein from rat skinned cardiac myocytes and rabbit skeletal muscle fibers. J Gen Physiol 1991;97:1141-63.
40. Witt CC, Gerull B, Davies MJ, Centner T, Linke WA, Thierfelder L. Hypercontractile properties of cardiac muscle fibers in a knock-in mouse model of cardiac myosin-binding protein-C. J Biol Chem 2001;276:5353-9.
41. Palmer BM, McConnell BK, Li GH, et al. Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Mol Cell Biochem 2004;263:73-80.
42. Palmer BM, Georgakopoulos D, Janssen PM, et al. Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening. Circ Res 2004;94:1249-55.
43. Stelzer JE, Fifzsimons DP, Moss RL. Ablation of myosin-binding protein-C accelerates force development in mouse myocardium. Biophys J 2006;90:4119-27.
44. Bonne G, Carrier L, Bercovici J, et al. Cardiac myosin binding protein-C gene splice acceptor site mutation is associated with familial Hypertrophic cardiomyopathy. Nature Genet 1995;11:43840.
45. Watkins H, Conner D, Thierfelder L, et al. Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy. Nature Genet 1995;11:434-7.
46. Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, Bild DE. Prevalence of hypertrophic cardiomyopathy in a general population of young adults: echocardiographic analysis of 4111 subjects in the CARDIA study. Circulation 1995;92:785-9.
47. Maron BJ Nichols PF, Pickle LW, Wesley YE, Mulvihill JJ. Patterns of inheritance in hypertrophic caraiomopathy. Assessment by M-mode and two-dimensional echocardiography. Am J Cardiol 1984;53:1087-94.
48. Bonne G, Carrier L, Richard P, Hainque B, Schwartz K. Familial hypertrophic cardiomyopathy: from mutations to functional defects. Circ Res 1998;83:579-93.
49. Keller DI, Carrier L, Schwartz K. Genetics of familial hypertrophic cardiomyopathies and arrhythmias. Swiss Medical Weekly 2002;132:401-7.
50. Carrier L, Bonne G, Bährend E, et al. Organization and sequence of human cardiac myosin binding protein C gene (MYBPC3) and identification of mutations predicted to produce truncated proteins in familial hypertrophic cardiomyopathy. Circ Res 1997;80:427-34.
51. Rottbauer W, Gautel M, Zehelein J, et al. Novel splice donor site mutation in the cardiac myosin-binding protein-C gene in familial hypertrophic cardiomyopathy. Characterization of cardiac transcript and protein. J Clin Invest 1997;100:475-82.
52. Moolman JA, Reith S, Uhl K, et al. A newly created splice donor site in exon 25 of the MyBP-C gene is responsible for inherited hypertrophic cardiomyopathy with incomplete disease penetrance. Circulation 2000;101:1396-402.
53. Flavigny J, Souchet M, Sebillon P, et al. COOH-terminal truncated cardiac myosin-binding protein C mutants resulting from familial hypertrophic cardiomyopathy mutations exhibit altered expression and/or incorporation in fetal rat cardiomyocytes. J Mol Biol 1999;294:443-56.
54. Yang Q, Sanbe A, Osinska H, Hewett TE, Klevitsky R. Robbins J. In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy. Circ Res 1999;85:841-7.
55. Sarikas A, Carrier L, Schenke C, et al. Impairment of the ubiquitin-proteasome system by truncated cardiac myosin binding protein C mutants. Cardiovasc Res 2005;66:33-44.
56. Day SM, Westfall MV, Fomicheva EV, et al. Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Nat Med 2006;12:181-9.
57. Oakley CE, Horribly BD, Curmi PM, Brown U. Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy. Cell Res 2004;14:95-110.