Effects of doxazosin enantiomers on blood pressure and urinary bladder function in anesthetized rats

Chinese Pharmacological Bulletin

Volumn 23, Issue 2, 2007, Pages 240-245

  Tian, He Lin ^a,b   Ren, Lei Ming ^a   He, Dong Wei ^a   Zhao, Ding ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b HEBEI UNIVERSITY OF ENGINEERING   (China)

Author keywords

Carotid blood pressure; Doxazosin; Enantiomers; Rat; Vesical micturition pressure

Indexed keywords

DOXAZOSIN;

ANESTHESIA; ARTICLE; BLADDER CAPACITY; BLADDER CONTRACTION; BLADDER FUNCTION; BLADDER PRESSURE; CAROTID ARTERY; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ENANTIOMER; HEART RATE; INFORMATION PROCESSING; MEAN ARTERIAL PRESSURE; MICTURITION REFLEX; NONHUMAN; SYSTOLIC BLOOD PRESSURE;

EID: 34247519175     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. MacDonald R, Wilt T J, Howe R W. Doxazosin for treating lower tract symptoms compatible with benign prostatic obstruction: a systematic review of efficacy and adverse effects[J], BJU Int, 2004, 94(9):1263-70.
2. Owens P K, Fell A F, Coleman M W, et al. Chiral recognition in liquid chromatography utilizing chargeable cyclodextrins for resolution of doxazosin enantiomers[J]. Chirality, 1997,9(2):184-90.
3. Hatano A, Tang R, Walden P D, Lepor H. The alpha-1 adrenoceptor antagonist properties of the enantiomers of doxazosin in human prostate[J]. Eur J Pharmacol, 1996,313(1-2):135-43.
4. Niu C Q, Ren L M. Chiral separation of three new antagonists of alpha-1 adrenoceptors by capillary electrophoresis[J]. Acta Pharmac Sin, 2000,35(6):451-3.
5. Niu C Q, Ren L M. Chiral separation and preparation of three new antagonists of alpha-1 adrenoceptors by chiral mobile phase HPLC [J]. Acta Pharmac Sin, 2002,37(6):450-3.
6. 1-Adrenoceptor antagonist profile of doxazosin and its enantiomers in isolated rabbit blood vessels[J]. Chin J Pharmacol Toxical, 2003,17(5):354-9.
7. Lin M J, Yang X P, Wang J, et al. S Nitrosocaptopril preferentially decreases diastolic pressure in hypertensive models[J]. Chin Pharmacol Bull, 1999,15(1):73-6.
8. Matsuura S, Allen G V, Downie J W. Volume-evoked micturition reflex is mediated by the ventrolateral periaqueductal gray in anesthetized rats[J]. Am J Physiol Regul Integr Comp Physiol, 1998, 275(6):2049-55.
9. Wang M, Zhao D, Zhao Q H, et al. Effects of adenosine triphosphate on motility of isolated gastric smooth muscle in rats[J]. Chin Pharmacol Bull, 2005,21(3):351-5.
10. Shi C X, Ren L M, Li J X. Effects of tetrodotoxin on biphasic vasoconstrictive responses to electric stimulation in rabbit saphenous artery[J]. Chin Pharmacol Bull, 2005,21(9):1123-8.
11. Kirby R S, Andersen M, Gratzke P, et al. A combined analysis of double-blind trial of the efficacy and tolerability of doxazosin- gastrointestinal therapeutic system, doxazosin, standard and placebo in patients with BPH[J]. BJU Int, 2001,87(3):192-200.
12. Donnelly R, Elliot H L, Howie C A, et al. Vascular pressor responses in treated and untreated hypertension[J]. J Cardiovasc Pharmacol, 1990,16(2):191-6.
13. Gu D G, Zhang Y Z, Mao S Y. Antihypertensive effect of doxazosin mesilate on SHR[J]. Acta Univ Med Sec Shanghai, 1996,16 (4):254-6.
14. 2- And β-adrenoceptors in the urinary bladder, urethra and prostate[J]. Br J Pharmacol, 2006, 147(S1):88-119.
15. Somogyi G T, Tanowitz M, Groat W C. Prejunctional facilitatory alpha1-adrenoceptors in the rat urinary bladder[J]. Br J Pharmacol, 1995,114(8):1710-6.
16. Yoshiyama M, Yamamoto T, Groat W C. Role of spinal α-adrenergic mechanisms in the control of lower urinary tract in the rat [J]. Brain Res, 2000,882(1-2):36-44.
17. Ishizuka O, Persson K, Mattiasson A, et al. Micturition in conscious rats with and without bladder outlet obstruction: role of spinal alpha1-adrenoceptors[J]. Br J Pharmacol, 1996,117(5): 962-6.