Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models

Brain Research

Volumn 1149, Issue 1, 2007, Pages 181-190

  Muramatsu, Yuko ^a   Furuichi, Yasuhisa ^a   Tojo, Nobuteru ^a   Moriguchi, Akira ^a   Maemoto, Takuya ^a   Nakada, Hirohisa ^a   Hino, Motohiro ^a   Matsuoka, Nobuya ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Calcineurin; Cyclophilin D; Focal ischemia; Global ischemia; Immunosuppressant; Mitochondrial permeability transition; Neuroprotection

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOSPORIN A; CYCLOSPORIN A DERIVATIVE; FR 901459; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN ISCHEMIA; CELL DAMAGE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; ENZYME INHIBITION; GERBIL; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; LIVER MITOCHONDRION; LYMPHOCYTE; MALE; MITOCHONDRION; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELL LINE, TUMOR; CYCLOSPORINE; GERBILLINAE; HUMANS; HYPOXIA, BRAIN; ISCHEMIC ATTACK, TRANSIENT; LYMPHOCYTE CULTURE TEST, MIXED; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; RATS;

GERBILLINAE; RATTUS;

EID: 34247513507     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.02.036     Document Type: Article

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