Effect of tetrandrine on endothelin expression in the lungs and clinical significance thereof: Experiment with rat models with nitrofen-induced congenital diaphragmatic hernia

National Medical Journal of China

Volumn 87, Issue 6, 2007, Pages 423-428

  Xiong, Zhong Xun ^a   Liu, Wen Ying ^a   Wang, Yong Gang ^a   Xu, Chang ^a   Chen, Zhong Xian ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Bronchopulmonary dysplasia; Hernia, diaphragmatic; Models, animal

Indexed keywords

DEXAMETHASONE; ENDOTHELIN; NITROFEN; TETRANDRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BODY WEIGHT; BRONCHIOLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAPHRAGM HERNIA; DRUG EFFICACY; DRUG MECHANISM; FEMALE; FETUS; IMMUNOHISTOCHEMISTRY; LUNG WEIGHT; NONHUMAN; OPTICAL DENSITY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZYLISOQUINOLINES; DISEASE MODELS, ANIMAL; ENDOTHELINS; FEMALE; HERNIA, DIAPHRAGMATIC; IMMUNOHISTOCHEMISTRY; LUNG; PHENYL ETHERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 34247511549     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Barth PJ, Kimpel C, Roy S, et al. An improved mathematical approach for the assessment of the medial thickness of pulmonary arteries. J Pathol Res Pract, 1993 189: 567-576.
2. Kyzer S, Sirota L, Chaimoff C. Abdominal wall closure with a silastic patch after repair of congenital diaphragmatic hernia. Arch Surg, 2004, 139: 296-298.
3. Piedboeuf B, Laberge JM, Gamache M, et al. Deleterious effects of tracheal obstruction on type II pneumocytes in the fetal sheep. Pediatr Res, 1997 41: 473-479.
4. Tannuri U, Rodrigues CJ, Maksoud-Filho JG, et al. The effects of prenatal intraamniotic surfactant or dexamethasone administration on lung development are comparable to changes induced by tracheal ligation in an animal model of congenital diaphragmatic hernia: studies of lung glycogen content, elastic fiber density, and collagen content. J Pediatr Surg, 1998, 33: 1776-783.
5. Wang G, Lemos JR, Iadecola C. Herbal alkaloid tetrandrine: fron an ion channel blocker to inhibitor of tumor proliferation. Trends Pharmacol Sci, 2004, 25: 120-123.
6. Liu WY, Feng JX, Jia HH, et al. Effect of prenatal tetrandrine therapy on pulmonary vascular structural remodeling in the nitrofen-induced CDH rat model. Chin Med J, 2000, 113: 813-816.
7. Harding R. Fetal pulmonary development: the role of respiratory movements. Equine Vet J Suppl, 1997, :32-39.
8. Kurihara H, Kimura S. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature, 1988, 322: 411-415.
9. Cheng D, Chen W, Mo X. Acute effect of tetrandrine pulmonary targeting microspheres on hypoxic, pulmonary hypertension in rats. Chin Med J, 2002, 115:81-83.