Interactions between aflatoxin B1 and dietary iron overload in hepatic mutagenesis

Toxicology

Volumn 234, Issue 3, 2007, Pages 157-166

  Asare, George A ^a   Bronz, Michelle ^a   Naidoo, Vivash ^b   Kew, Michael C ^a  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Aflatoxin B1; Iron overload; Mutagenesis; p53 mutation; Synergy

Indexed keywords

4 HYDROXYNONENAL; 8 HYDROXYDEOXYGUANOSINE; AFLATOXIN B1; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOKINE; FERROCENE; FREE RADICAL; INTERLEUKIN 10; INTERLEUKIN 6; IRON; LIPID; NITRITE; SUPEROXIDE; 4-HYDROXY-2-NONENAL; 8-HYDROXY-2'-DEOXYGUANOSINE; ALDEHYDE; DEOXYGUANOSINE; DRUG DERIVATIVE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDE; NITRATE; TRANSFERRIN; UNCLASSIFIED DRUG;

AMES TEST; ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA DAMAGE; FEEDING; IMMUNOHISTOCHEMISTRY; IRON INTAKE; IRON OVERLOAD; LIPID PEROXIDATION; LIVER CARCINOMA; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT; RISK FACTOR; ANIMAL; BLOOD; DRUG EFFECT; GENETICS; LIVER; METABOLISM; MUTAGEN TESTING; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; WISTAR RAT;

RATTUS;

AFLATOXIN B1; ALANINE TRANSAMINASE; ALDEHYDES; ANIMALS; ASPARTATE AMINOTRANSFERASES; CYTOKINES; DEOXYGUANOSINE; DNA DAMAGE; GLUTATHIONE TRANSFERASE; IMMUNOHISTOCHEMISTRY; IRON; IRON OVERLOAD; LIPID PEROXIDES; LIVER; MUTAGENESIS; MUTAGENICITY TESTS; NITRATES; NITRITES; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDES; TRANSFERRIN;

EID: 34247498699     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.02.009     Document Type: Article

References (40)

1. Asare G.A., Mossanda K.S., Kew M.C., Paterson A.C., Kahler-Venter C.P., and Siziba K. Hepatocellular carcinoma caused by iron overload: a possible mechanism of direct hepatocarcinogenicity. Toxicology 219 (2006) 41-52
2. Asare G.A., Paterson A.C., Kew M.C., Khan S., and Mossanda K.S.A. Iron-free neoplastic nodules and hepatocellular carcinoma without cirrhosis in Wistar rats fed a diet high in iron. J. Pathol. 208 (2006) 82-90
3. Berenbaum M.C. The expected effect of a combination of agents: the general solution. J. Theor. Biol. 114 3 (1985) 413-431
4. Bothwell T.H., and Bradlow B.A. Siderosis in the Bantu: a combined histopathological and chemical study. Arch. Pathol. 70 (1960) 279-292
5. Bressac B., Kew M.C., Wands J., and Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 350 (1991) 429-431
6. Britton R.S. Metal-induced hepatoxicity. Semin. Liver Dis. 16 (1996) 3-12
7. Cheeseman K.H. Lipid peroxidation in cancer. In: Halliwell B., and Arouma A.I. (Eds). DNA and Free Radicals (1993), Ellis Horwood, London 109-144
8. Cheng K.C., Cahill D.S., Kasai H., Nishimura S., and Loeb L.A. 8-Hydroxyl guanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J. Biol. Chem. 267 (1992) 166-172
9. Crofton M.C., Craft E.S., Hedge J.M., Gennings C., Simmons J.E., Carchman R.A., Carter Jr. W.H., and DeVito M.J. Thyroid-hormone-disrupting chemicals: evidence of dose-dependent additivity or synergism. Environ. Health Perspec. 113 (2005) 11
10. Dabbagh A.J., Mannion T., Lynch S.M., and Frei B. The effect of iron overload on rat plasma and liver oxidant status in vivo. Biochem. J. 300 (1994) 799-803
11. Feng Z., Hu W., and Tang M.S. Trans-4-hydroxy-2-noneal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced cacinogenesis. Proc. Natl. Acad. Sci. USA 101 (2004) 8598-9602
12. Fiddler R.N. Collaborative study of modified AOAC method of analysis for nitrite in meat and meat products. J. Assoc. Anal. Chem. 60 3 (1977) 594-599
13. Gordeuk V.R., Boyd R.D., and Brittenham G.H. Dietary iron overload persists in sub-Saharan Africa. Lancet 1 (1986) 1310-1313
14. Gordeuk V.R., McLaren C.E., MacPhail A.P., Deichsel G., and Bothwell T.H. Associations of iron overload in Africa and hepatocellular carcinoma and tuberculosis. Blood 87 (1996) 3476-3479
15. Hagen T.M., Huang S., Curnutte J., Fowler P., Martinez V., Wehr C.M., Ames B.N., and Chisari F.V. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 91 26 (1994) 12808-12812
16. Hsu I.C., Metcalf R.A., Sun T., Welsh J.A., Wang N.J., and Harris C.C. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 350 6317 (1991) 427-428
17. Hussain S.P., Raja K., Amstad P.A., Sawyer M., Trudel L.J., Wogan G.N., Hofseth L.J., Shields P.G., Billiar T.R., Trautwein C., Hohler T., Galle P.R., Phillips D.H., Markin R., Marrogi A.J., and Harris C.C. Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. Proc. Natl. Acad. Sci. USA 97 23 (2000) 12770-12775
18. Ichiba M., Maeta Y., Mukoyama T., Saeki T., Yasui S., Kanbe T., Okano J., Tanabe Y., Hirooka Y., Yamada S., Kurimasa A., Murawaki Y., and Shiota. Expression of 8-hydroxy-2′-deoxyguanosine in chronic liver disease and hepatocellular carcinoma. Liver Int. 23 (2003) 338-345
19. Jungst C., Cheng B., Gehrke R., Schmitz V., Nischalke H.D., Ramakers J., Schramel P., Schirmacher T., and Caselmann W.H. Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma. Hepatology 39 (2004) 1663-1672
20. Kensler T.W., Qian G.S., Chen J.G., and Groopman J.D. Translational strategies for cancer prevention in liver. Nat. Rev. 3 (2003) 321-329
21. 1 and hepatitis B virus in hepatocarcinogenesis. Liver Int. 23 (2003) 1-5
22. Kew M.C. Chronic hepatitis-B virus infection and hepatocellular carcinoma in Africa. S. Afric. J. Sci. 88 (1992) 524-528
23. Kim Y.M., Chung H.T., Simmons R.L., and Billiar T.R. Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition. J. Biol. Chem. 275 (2000) 10954-10961
24. Kuldip T., Abdel-Rahman E., and Paresh D. Measurement of reactive oxygen species in whole blood and mononuclear cells using chemiluminescence. Meth. Mol. Biol. 108 (1998) 57-62
25. Lee P., Peng H., Terri G., Wang L., and Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc. Natl. Acad. Sci. USA 102 6 (2004) 1096-1910
26. Loewe S., and Muischnek H. Effect of combinations: mathematical basis of a problem. Naunyn Schmiedebergs Arch. Exp. Pathol. Pharmakol. 114 (1926) 313-326
27. Loewe S. The problem of synergism and antagonism of combined drugs. Arzeimittelforschung 3 6 (1953) 285-290
28. Ma Y., Zhang D., Kawabata T., Kiriu T., Toyokuni S., Uchida K., et al. Copper and iron-induced oxidative damage in non-tumor bearing LEC rats. Pathol. Int. 47 (1997) 203-208
29. Mandishona E., McPhail A.P., Gordeuk V.R., Kedda M.A., Paterson C., Rouault T.A., Kew M.C., et al. Dietary iron overload as a risk factor for hepatocellular carcinoma in black Africans. Hepatology 27 (1998) 1563
30. Maron D.M., and Ames B.M. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113 (1983) 173-215
31. Marrogi A.J., Khan M.A., van Gijssel H.E., Welsh J.A., Rahim H., Demetris A.J., Kowdley K.V., Hussain S.P., Nair J., Bartsch H., Okby N., Poirier M.C., Ishak K.G., and Harris C.C. Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma. J. Natl. Cancer Inst. 93 21 (2001) 1652-1655
32. McNamara L., MacPhail A.P., Mandishona E., Bloom P., Paterson A.C., Rouault T.A., and Gordeuk V.R. Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload. J. Gastroenterol. Hepatol. 14 2 (1999) 126-132
33. Moyo V.M., Makunike R., Gangaidzo I.T., Gordeuk V.R., McLaren C.E., Khumalo H., Saungweme T., Rouault T., and Kiire C.F. African iron overload and hepatocellular carcinoma. Eur. J. Hematol. 60 (1998) 28-34
34. Nourooz-Zadeh J., Tajaddini-Sarma D.I., and Wolff S.P. Measurement of plasma hydroperoxide concentration by the ferrous oxidation-xylenol assay in conjunction with triphenylphosphine. Anal. Biochem. 220 (1994) 403-409
35. 1. J. Cell Biochem. 91 2 (2004) 243-249
36. Sudakin D.L. Dietary aflatoxin exposure and chemoprevention of cancer: a clinical review. J. Toxicol. Clin. Toxicol. 41 (2003) 195-204
37. Toyokuni S., Iwasa Y., Kondo S., Tanaka T., Ochi H., and Hiai H. Intracellular distribution of 8-hydroxy-deoxyguanosine. An immunocytochemical study. J. Histochem. Cytochem. 47 6 (1999) 833-836
38. Toyokuni S., Tanaka T., Hattori Y., Nisjiyama Y., Yoshida A., Uchida K., Hiai H., Ochi H., and Osawa T. Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by monoclonal N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab. Invest. 76 (1997) 365-374
39. Vautier G., Bomford A.B., Portmann B.C., Metivier E., Williams R., and Ryder S.D. p53 mutations in British patients with hepatocellular carcinoma: clustering in genetic hemochromatosis. Gastroenterology 117 1 (1999) 154-160
40. Wild C.P., and Turner P.C. The toxicology of aflatoxins as a basis for public health decisions. Mutagenesis 17 (2002) 471-481