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Volumn 32, Issue 2, 2007, Pages 161-170

Selective α7 nicotinic acetylcholine receptor ligands for the treatment of neuropsychiatric diseases

Author keywords

[No Author keywords available]

Indexed keywords

(2 AMINO 5 KETO)THIAZOLE DERIVATIVE; 3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; 3 ETHYNYL 5 (1 METHYL 2 PYRROLIDINYL)PYRIDINE FUMARATE; 3 PYRAZINOXYQUINUCLIDINE DERIVATIVE; 5 HYDROXYINDOLE; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGAND; ARR 17779; ARR 234655; BENZAMIDE DERIVATIVE; BUNGAROTOXIN RECEPTOR; DIHYDRO BETA ERYTHROIDINE; DRUG METABOLITE; GALANTAMINE; IVERMECTIN; MEM 3454; MEM 63908; NICOTINE; NICOTINIC AGENT; OXAZOLIDINONE DERIVATIVE; PHA 543613; PHA 543913; PNU 120596; PNU 282987; PSAB OFP; QUINUCLIDINE BENZAMIDE DERIVATIVE; QUINUCLIDINE DERIVATIVE; SPIRO [1AZABICYCLO[2.2.2] OCTANE 3,5 OXAZOLIDIN] 2 ONE DERIVATIVE; SSR 180711; TC 5619; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 34247486496     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2007.032.02.1064020     Document Type: Review
Times cited : (24)

References (80)
  • 1
    • 0035886019 scopus 로고    scopus 로고
    • Ultrastructural distribution of the alpha7 nicotinic acetylcholine receptor subunit in rat hippocampus
    • Fabian-Fine, R., Skehel, P., Errington, M.L. et al. Ultrastructural distribution of the alpha7 nicotinic acetylcholine receptor subunit in rat hippocampus. J Neurosci 2001, 21(20): 7993-8003.
    • (2001) J Neurosci , vol.21 , Issue.20 , pp. 7993-8003
    • Fabian-Fine, R.1    Skehel, P.2    Errington, M.L.3
  • 2
    • 0036325889 scopus 로고    scopus 로고
    • Direct evidence that release-stimulating alpha7 nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals
    • Marchi, M., Risso, F., Viola, C. et al. Direct evidence that release-stimulating alpha7 nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals. J Neurochem 2002, 80: 1071-8.
    • (2002) J Neurochem , vol.80 , pp. 1071-1078
    • Marchi, M.1    Risso, F.2    Viola, C.3
  • 3
    • 0036890828 scopus 로고    scopus 로고
    • Nicotinic receptor subtypes and cognitive function
    • Levin, E.D. Nicotinic receptor subtypes and cognitive function. J Neurobiol 2002, 53(4): 633-40.
    • (2002) J Neurobiol , vol.53 , Issue.4 , pp. 633-640
    • Levin, E.D.1
  • 4
    • 0037154981 scopus 로고    scopus 로고
    • Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory
    • Levin, E.D., Bradley, A., Addy, N. et al. Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory. Neuroscience 2002, 109(4): 757-65.
    • (2002) Neuroscience , vol.109 , Issue.4 , pp. 757-765
    • Levin, E.D.1    Bradley, A.2    Addy, N.3
  • 5
    • 3242813711 scopus 로고    scopus 로고
    • Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients
    • De Luca, V., Wong, A.H., Muller, D.J. et al. Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients. Neuropsychopharmacology 2004, 29(8): 1522-6.
    • (2004) Neuropsychopharmacology , vol.29 , Issue.8 , pp. 1522-1526
    • De Luca, V.1    Wong, A.H.2    Muller, D.J.3
  • 6
    • 0034732116 scopus 로고    scopus 로고
    • Smoking and schizophrenia: Abnormal nicotinic receptor expression
    • Leonard, S., Breese, C., Adams, C. et al. Smoking and schizophrenia: Abnormal nicotinic receptor expression. Eur J Pharmacol 2000, 393(1-3): 237-42.
    • (2000) Eur J Pharmacol , vol.393 , Issue.1-3 , pp. 237-242
    • Leonard, S.1    Breese, C.2    Adams, C.3
  • 7
    • 19244378105 scopus 로고    scopus 로고
    • Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases
    • Perry, E., Martin-Ruiz, C., Lee, M. et al. Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases. Eur J Pharmacol 2000, 393(1-3): 215-22.
    • (2000) Eur J Pharmacol , vol.393 , Issue.1-3 , pp. 215-222
    • Perry, E.1    Martin-Ruiz, C.2    Lee, M.3
  • 8
    • 34247546847 scopus 로고    scopus 로고
    • Partial agonists as therapeutic agents at neuronal nicotinic acetylcholine receptors
    • Epub ahead of print
    • Hogg, R.C., Bertrand, D. Partial agonists as therapeutic agents at neuronal nicotinic acetylcholine receptors. Biochem Pharmacol 2006, Epub ahead of print.
    • (2006) Biochem Pharmacol
    • Hogg, R.C.1    Bertrand, D.2
  • 9
    • 0034597576 scopus 로고    scopus 로고
    • Mullen, G., Napier, J, Balestra, M. et al. (-)-Spiro[1-azabicyclo[2.2. 2]octane-3,5′-oxazolidin-2′-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. J Med Chem 2000, 43(22): 4045-50.
    • Mullen, G., Napier, J, Balestra, M. et al. (-)-Spiro[1-azabicyclo[2.2. 2]octane-3,5′-oxazolidin-2′-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. J Med Chem 2000, 43(22): 4045-50.
  • 10
    • 34247512731 scopus 로고    scopus 로고
    • Phillips, E, Mack, R, Macor, J. et al, Astra AB Novel spiroazabicyclic heterocyclic compounds. WO 9903859
    • Phillips, E., Mack, R., Macor, J. et al. (Astra AB) Novel spiroazabicyclic heterocyclic compounds. WO 9903859.
  • 11
    • 0037020529 scopus 로고    scopus 로고
    • PSAB-OFP, a selective alpha 7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptor
    • Broad, L.M., Felthouse, C., Zwart, R. et al. PSAB-OFP, a selective alpha 7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptor. Eur J Pharmacol 2002, 452(2): 137-44.
    • (2002) Eur J Pharmacol , vol.452 , Issue.2 , pp. 137-144
    • Broad, L.M.1    Felthouse, C.2    Zwart, R.3
  • 12
    • 13944267447 scopus 로고    scopus 로고
    • Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors
    • Bodnar, A.L., Cortes-Burgos, L.A., Cook, K.K. et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem 2005, 48(4): 905-8.
    • (2005) J Med Chem , vol.48 , Issue.4 , pp. 905-908
    • Bodnar, A.L.1    Cortes-Burgos, L.A.2    Cook, K.K.3
  • 13
    • 14344251489 scopus 로고    scopus 로고
    • Hajos, M., Hurst, R.S., Hoffmann, W.E. et al. The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-azabicyclo[2.2.2] oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. J Pharmacol Exp Ther 2005, 312(3): 1213-22.
    • Hajos, M., Hurst, R.S., Hoffmann, W.E. et al. The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-azabicyclo[2.2.2] oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. J Pharmacol Exp Ther 2005, 312(3): 1213-22.
  • 15
    • 33845698922 scopus 로고    scopus 로고
    • SSR180711, a novel selective α7 nicotinic receptor partial agonist: (1) Binding and functional profile
    • Biton, B., Bergis, O.E., Galli, R et al. SSR180711, a novel selective α7 nicotinic receptor partial agonist: (1) Binding and functional profile. Neuropsychopharmacology 2007, 32(1):1-16.
    • (2007) Neuropsychopharmacology , vol.32 , Issue.1 , pp. 1-16
    • Biton, B.1    Bergis, O.E.2    Galli, R.3
  • 16
    • 33745872934 scopus 로고    scopus 로고
    • Tatsumi, R., Fujio, M., Takanashi, S. et al. (R)-3′-(3- Methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3, 5′-oxazolidin]-2′-one, a novel and potent alpha7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties. J Med Chem 2006, 49(14): 4374-83.
    • Tatsumi, R., Fujio, M., Takanashi, S. et al. (R)-3′-(3- Methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3, 5′-oxazolidin]-2′-one, a novel and potent alpha7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties. J Med Chem 2006, 49(14): 4374-83.
  • 17
    • 0031003185 scopus 로고    scopus 로고
    • Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo
    • Briggs, C.A., Anderson, D.J., Brioni, J.D. et al. Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol Biochem Behav 1997, 57(1-2): 231-41.
    • (1997) Pharmacol Biochem Behav , vol.57 , Issue.1-2 , pp. 231-241
    • Briggs, C.A.1    Anderson, D.J.2    Brioni, J.D.3
  • 18
    • 0038210322 scopus 로고    scopus 로고
    • Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands
    • Astles, P.C., Baker, S.R., Boot, J.R. et al. Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands. Curr Drug Targets CNS Neurol Disord 2002, 1(4): 337-48.
    • (2002) Curr Drug Targets CNS Neurol Disord , vol.1 , Issue.4 , pp. 337-348
    • Astles, P.C.1    Baker, S.R.2    Boot, J.R.3
  • 19
    • 9144251593 scopus 로고    scopus 로고
    • Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): Their molecular properties, interactions with brain nicotinic receptors and brain penetration
    • Kern, V.R., Mahnir, V.M., Prokai, L. et al. Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): Their molecular properties, interactions with brain nicotinic receptors and brain penetration. Mol Pharmacol 2004, 65: 56-67.
    • (2004) Mol Pharmacol , vol.65 , pp. 56-67
    • Kern, V.R.1    Mahnir, V.M.2    Prokai, L.3
  • 20
    • 0035192882 scopus 로고    scopus 로고
    • Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine3A receptor
    • Machu, T.K., Hamilton, M.E., Frye, T.F. et al. Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine3A receptor. J Pharmacol Exp Ther 2001, 299: 1112-9.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 1112-1119
    • Machu, T.K.1    Hamilton, M.E.2    Frye, T.F.3
  • 21
    • 34247530112 scopus 로고    scopus 로고
    • Phillips, E, Schmiesing, R, AstraZeneca AB, Novel biaryl-carboxamides. WO 0160821
    • Phillips, E., Schmiesing, R. (AstraZeneca AB). Novel biaryl-carboxamides. WO 0160821.
  • 22
    • 2942620549 scopus 로고    scopus 로고
    • Tatsumi, R., Seio, K., Fujio, M. et al. (+)-3-[2-(Benzo[b]thiophen-2- yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the alpha7 nicotinic acetylcholine receptor. Bioorg Med Chem Lett 2004, 14(14): 3781-4.
    • Tatsumi, R., Seio, K., Fujio, M. et al. (+)-3-[2-(Benzo[b]thiophen-2- yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the alpha7 nicotinic acetylcholine receptor. Bioorg Med Chem Lett 2004, 14(14): 3781-4.
  • 23
    • 17144370948 scopus 로고    scopus 로고
    • Tatsumi, R., Fujio, M., Satoh, H. et al. Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3′-(5-Chlorothiophen-2-yl) spiro-1-azabicyclo[2.2.2]octane-3,5′-[1′,3′] oxazolidin-2′-one as a novel, potent, selective, and orally bioavailable ligand. J Med Chem 2005, 48(7): 2678-86.
    • Tatsumi, R., Fujio, M., Satoh, H. et al. Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3′-(5-Chlorothiophen-2-yl) spiro-1-azabicyclo[2.2.2]octane-3,5′-[1′,3′] oxazolidin-2′-one as a novel, potent, selective, and orally bioavailable ligand. J Med Chem 2005, 48(7): 2678-86.
  • 24
    • 33745808357 scopus 로고    scopus 로고
    • Wishka, D.G., Walker, D.P., Yates, K.M. et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia. Synthesis and structure-activity relationship. J Med Chem 2006, 49(14): 4425-36.
    • Wishka, D.G., Walker, D.P., Yates, K.M. et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia. Synthesis and structure-activity relationship. J Med Chem 2006, 49(14): 4425-36.
  • 25
    • 34247536504 scopus 로고    scopus 로고
    • Assessment of a full α7 nicotinic acetylcholine receptor agonist, TC-5619, in animal models of schizophrenia
    • Nov 12-15, Washington, D.C, Abst 952.10
    • Jordan, K.J., Gatto, G.J., Hauser, T.A. et al. Assessment of a full α7 nicotinic acetylcholine receptor agonist, TC-5619, in animal models of schizophrenia. 35th Annu Meet Soc Neurosci (Nov 12-15, Washington, D.C.). 2005, Abst 952.10.
    • (2005) 35th Annu Meet Soc Neurosci
    • Jordan, K.J.1    Gatto, G.J.2    Hauser, T.A.3
  • 26
    • 34247484192 scopus 로고    scopus 로고
    • Feuerbach, D, Hurth, K, Ritchie, T.J, Novartis AG; Novartis Pharma GmbH, Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonist. WO 2004022556
    • Feuerbach, D., Hurth, K., Ritchie, T.J. (Novartis AG; Novartis Pharma GmbH). Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonist. WO 2004022556.
  • 27
    • 34247522522 scopus 로고    scopus 로고
    • Feuerbach, D, Roy, B.L, Troxler, T.J, Hurth, K, Novartis AG; Novartis Pharma GmbH, 3-(Heteroaryl-oxy)-2-alkyl-1-azabicycloalkyl derivatives as alpha.7-nAChR ligands for the treatment of CNS diseases. WO 2006005608
    • Feuerbach, D., Roy, B.L., Troxler, T.J., Hurth, K. (Novartis AG; Novartis Pharma GmbH). 3-(Heteroaryl-oxy)-2-alkyl-1-azabicycloalkyl derivatives as alpha.7-nAChR ligands for the treatment of CNS diseases. WO 2006005608.
  • 28
    • 34247479221 scopus 로고    scopus 로고
    • Kohlhaas, K.L, Rueter, L.E, Bitner, R.S, Abbott Lab, Alpha7 neuronal nicotinic receptor ligand and antipsychotic compositions. US 2006311686
    • Kohlhaas, K.L., Rueter, L.E., Bitner, R.S. (Abbott Lab.). Alpha7 neuronal nicotinic receptor ligand and antipsychotic compositions. US 2006311686.
  • 29
    • 34247486299 scopus 로고    scopus 로고
    • Empfield, J, Phillips, E, Throner, S, AstraZeneca AB, 4-Substituted imidazoles. WO 2005049612
    • Empfield, J., Phillips, E., Throner, S. (AstraZeneca AB). 4-Substituted imidazoles. WO 2005049612.
  • 30
    • 34247477412 scopus 로고    scopus 로고
    • Empfield, J, Phillips, E, Throner, S, AstraZeneca AB, 5-Substituted imidazoles. WO 2005049611
    • Empfield, J., Phillips, E., Throner, S. (AstraZeneca AB). 5-Substituted imidazoles. WO 2005049611.
  • 31
    • 34247468636 scopus 로고    scopus 로고
    • Ernst, G, Frietze, W, Jacobs, R, Phillips, E, AstraZeneca AB, Nicotinic acetylcholine receptor ligands. WO 2005061510
    • Ernst, G., Frietze, W., Jacobs, R., Phillips, E. (AstraZeneca AB). Nicotinic acetylcholine receptor ligands. WO 2005061510.
  • 32
    • 34247532583 scopus 로고    scopus 로고
    • Benedetti, Y, Bohme, A, Genevois-Borella, A, Touyer, G, Zhang, J, Aventis Pharma SA, Triazine derivatives, their preparation and therapeutic application thereof. WO 2006111662
    • Benedetti, Y., Bohme, A., Genevois-Borella, A., Touyer, G., Zhang, J. (Aventis Pharma SA). Triazine derivatives, their preparation and therapeutic application thereof. WO 2006111662.
  • 33
    • 34247465778 scopus 로고    scopus 로고
    • Herbert, B, Nguyen, T.M, Tehim, A, Hopper, A.T, Xie, W, Memory Pharmaceuticals Corp, Anabaseine derivatives useful in the treatment of neurodegenerative diseases. WO 2004019943
    • Herbert, B., Nguyen, T.M., Tehim, A., Hopper, A.T., Xie, W. (Memory Pharmaceuticals Corp.). Anabaseine derivatives useful in the treatment of neurodegenerative diseases. WO 2004019943.
  • 34
    • 34247544763 scopus 로고    scopus 로고
    • Xie, W, Herbert, B, Schumacher, R, Nguyen, T.M, Ma, J, Gauss, C.M, Tehim, A, Memory Pharmaceuticals Corp, Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof. WO 2005092890
    • Xie, W., Herbert, B., Schumacher, R., Nguyen, T.M., Ma, J., Gauss, C.M., Tehim, A. (Memory Pharmaceuticals Corp.), Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof. WO 2005092890.
  • 35
    • 34247463981 scopus 로고    scopus 로고
    • Xie, W, Herbert, B, Nguyen, T.M, Gauss, C.M, Tehim, A, Memory Pharmaceuticals Corp, Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof. WO 2004029050
    • Xie, W., Herbert, B., Nguyen, T.M., Gauss, C.M., Tehim, A. (Memory Pharmaceuticals Corp.). Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof. WO 2004029050.
  • 36
    • 34247527102 scopus 로고    scopus 로고
    • Xie, W, Herbert, B, Schumacher, R.A, Ma, J, Nguyen, T.M, Gauss, C.M, Tehim, A, Memory Pharmaceuticals Corp, 1H-Indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof. WO 2005111038
    • Xie, W., Herbert, B., Schumacher, R.A., Ma, J., Nguyen, T.M., Gauss, C.M., Tehim, A. (Memory Pharmaceuticals Corp.). 1H-Indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof. WO 2005111038.
  • 37
    • 34247517071 scopus 로고    scopus 로고
    • Luithle, J, Boess, F.-G, Erb, C. et al, Bayer AG, Azabicyclic N-biarylamides with affinity for the alpha-7 nicotinic acetylcholine receptor. WO 03078431
    • Luithle, J., Boess, F.-G., Erb, C. et al. (Bayer AG). Azabicyclic N-biarylamides with affinity for the alpha-7 nicotinic acetylcholine receptor. WO 03078431.
  • 38
    • 34247530111 scopus 로고    scopus 로고
    • Plessner, T, Boess, F.-G, Erb, C. et al, Bayer Healthcare AG, Benzothiophene urea, benzofurane urea, and indole urea, and use of the same as alpha-7 AChR agonists. WO 2004013136
    • Plessner, T., Boess, F.-G., Erb, C. et al. (Bayer Healthcare AG). Benzothiophene urea, benzofurane urea, and indole urea, and use of the same as alpha-7 AChR agonists. WO 2004013136.
  • 39
    • 0036711318 scopus 로고    scopus 로고
    • 5-Hydroxyindole potentiates human alpha 7 nicotinic receptor-mediated responses and enhances acetylcholine-induced glutamate release in cerebellar slices
    • Zwart, R., De Filippi, G., Broad, L.M. et al. 5-Hydroxyindole potentiates human alpha 7 nicotinic receptor-mediated responses and enhances acetylcholine-induced glutamate release in cerebellar slices. Neuropharmacology 2002, 43(3): 374-84.
    • (2002) Neuropharmacology , vol.43 , Issue.3 , pp. 374-384
    • Zwart, R.1    De Filippi, G.2    Broad, L.M.3
  • 40
    • 0031887759 scopus 로고    scopus 로고
    • Ivermectin: A positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor
    • Krause, R.M., Buisson, B., Bertrand, S. et al. Ivermectin: A positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor. Mol Pharmacol 1998, 53: 283-94.
    • (1998) Mol Pharmacol , vol.53 , pp. 283-294
    • Krause, R.M.1    Buisson, B.2    Bertrand, S.3
  • 41
    • 10744232323 scopus 로고    scopus 로고
    • Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors
    • Samochocki, M., Hoffle, A., Fehrenbacher, A. et al. Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J Pharmacol Exp Ther 2003, 305(3): 1024-36.
    • (2003) J Pharmacol Exp Ther , vol.305 , Issue.3 , pp. 1024-1036
    • Samochocki, M.1    Hoffle, A.2    Fehrenbacher, A.3
  • 42
    • 33747597579 scopus 로고    scopus 로고
    • Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators
    • Broad, L.M., Zwart, R., Pearson, K.H. et al. Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J Pharmacol Exp Ther 2006, 318(3): 1108-17.
    • (2006) J Pharmacol Exp Ther , vol.318 , Issue.3 , pp. 1108-1117
    • Broad, L.M.1    Zwart, R.2    Pearson, K.H.3
  • 43
    • 20944441082 scopus 로고    scopus 로고
    • A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: In vitro and in vivo characterization
    • Hurst, R.S., Hajos, M., Raggenbass, M. et al. A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: In vitro and in vivo characterization. J Neurosci 2005, 25(17): 4396-405.
    • (2005) J Neurosci , vol.25 , Issue.17 , pp. 4396-4405
    • Hurst, R.S.1    Hajos, M.2    Raggenbass, M.3
  • 44
    • 34247472353 scopus 로고    scopus 로고
    • Pharmacological and electrophysiological characterisation of a new class of selective alpha-7 nicotinic receptor potentiators
    • Nov 12-15, Washington, D.C, Abst 951.10
    • Sher, E., Zwart, R., De Filippi, G. et al. Pharmacological and electrophysiological characterisation of a new class of selective alpha-7 nicotinic receptor potentiators. 35th Annu Meet Soc Neurosci (Nov 12-15, Washington, D.C.) 2005, Abst 951.10.
    • (2005) 35th Annu Meet Soc Neurosci
    • Sher, E.1    Zwart, R.2    De Filippi, G.3
  • 45
    • 0035477336 scopus 로고    scopus 로고
    • Regulation of GABA release by nicotinic acetylcholine receptors in the neonatal rat hippocampus
    • Maggi, L., Sher, E., Cherubini, E. Regulation of GABA release by nicotinic acetylcholine receptors in the neonatal rat hippocampus. J Physiol 2001, 536: 89-100.
    • (2001) J Physiol , vol.536 , pp. 89-100
    • Maggi, L.1    Sher, E.2    Cherubini, E.3
  • 46
    • 0035896367 scopus 로고    scopus 로고
    • Acute and chronic nicotine exposure reverse age-related declines in the induction of long-term potentiation in the rat hippocampus
    • Fujii, S., Sumikawa, K. Acute and chronic nicotine exposure reverse age-related declines in the induction of long-term potentiation in the rat hippocampus. Brain Res 2001, 894(2): 347-53.
    • (2001) Brain Res , vol.894 , Issue.2 , pp. 347-353
    • Fujii, S.1    Sumikawa, K.2
  • 47
    • 0033784185 scopus 로고    scopus 로고
    • Activation of nicotinic acetylcholine receptors induces long-term potentiation in vivo in the intact mouse dentate gyrus
    • Matsuyama, S., Matsumoto, A., Enomoto, T. et al. Activation of nicotinic acetylcholine receptors induces long-term potentiation in vivo in the intact mouse dentate gyrus. Eur J Neurosci 2000, 12(10): 3741-7.
    • (2000) Eur J Neurosci , vol.12 , Issue.10 , pp. 3741-3747
    • Matsuyama, S.1    Matsumoto, A.2    Enomoto, T.3
  • 48
    • 33746870022 scopus 로고    scopus 로고
    • Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory
    • Fernandes, C., Hoyle, E., Dempster, E. et al. Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav 2006, 5(6): 433-40.
    • (2006) Genes Brain Behav , vol.5 , Issue.6 , pp. 433-440
    • Fernandes, C.1    Hoyle, E.2    Dempster, E.3
  • 49
    • 33750613621 scopus 로고    scopus 로고
    • Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task
    • Hoyle, E., Genn, R.F., Fernandes, C. et al. Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task. Psychopharmacology (Berl) 2006, 189(2): 211-23.
    • (2006) Psychopharmacology (Berl) , vol.189 , Issue.2 , pp. 211-223
    • Hoyle, E.1    Genn, R.F.2    Fernandes, C.3
  • 50
    • 33751334112 scopus 로고    scopus 로고
    • Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice
    • Young, J.W., Crawford, N., Kelly, J.S. et al. Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice. Eur Neuropsychopharmacol 2007, 17(2): 145-55.
    • (2007) Eur Neuropsychopharmacol , vol.17 , Issue.2 , pp. 145-155
    • Young, J.W.1    Crawford, N.2    Kelly, J.S.3
  • 51
    • 1942420850 scopus 로고    scopus 로고
    • Nicotine improves sustained attention in mice: Evidence for involvement of the alpha7 nicotinic acetylcholine receptor
    • Young, J.W., Finlayson, K., Spratt, C. et al. Nicotine improves sustained attention in mice: Evidence for involvement of the alpha7 nicotinic acetylcholine receptor. Neuropsychopharmacology 2004, 29(5): 891-900.
    • (2004) Neuropsychopharmacology , vol.29 , Issue.5 , pp. 891-900
    • Young, J.W.1    Finlayson, K.2    Spratt, C.3
  • 52
    • 0034694951 scopus 로고    scopus 로고
    • Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task
    • Grottick, A.J., Higgins, G.A. Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task. Behav Brain Res 2000, 117(1-2): 197-208.
    • (2000) Behav Brain Res , vol.117 , Issue.1-2 , pp. 197-208
    • Grottick, A.J.1    Higgins, G.A.2
  • 53
    • 0031938318 scopus 로고    scopus 로고
    • Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils
    • Nanri, M., Yamamoto, J., Miyake, H. et al. Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils. Jpn J Pharmacol 1998, 76(1): 23-9.
    • (1998) Jpn J Pharmacol , vol.76 , Issue.1 , pp. 23-29
    • Nanri, M.1    Yamamoto, J.2    Miyake, H.3
  • 54
    • 0032421378 scopus 로고    scopus 로고
    • GTS-21, a nicotinic agonist, attenuates multiple infarctions and cognitive deficit caused by permanent occlusion of bilateral common carotid arteries in rats
    • Nanri, M., Miyake, H., Murakami, Y. et al. GTS-21, a nicotinic agonist, attenuates multiple infarctions and cognitive deficit caused by permanent occlusion of bilateral common carotid arteries in rats. Jpn J Pharmacol 1998, 78(4): 463-9.
    • (1998) Jpn J Pharmacol , vol.78 , Issue.4 , pp. 463-469
    • Nanri, M.1    Miyake, H.2    Murakami, Y.3
  • 55
    • 0030859444 scopus 로고    scopus 로고
    • GTS-21, a nicotinic agonist, protects against neocortical neuronal cell loss induced by the nucleus basalis magnocellularis lesion in rats
    • Nanri, M., Kasahara, N., Yamamoto, J. et al. GTS-21, a nicotinic agonist, protects against neocortical neuronal cell loss induced by the nucleus basalis magnocellularis lesion in rats. Jpn J Pharmacol 1997, 74(3): 285-9.
    • (1997) Jpn J Pharmacol , vol.74 , Issue.3 , pp. 285-289
    • Nanri, M.1    Kasahara, N.2    Yamamoto, J.3
  • 56
    • 0002100551 scopus 로고    scopus 로고
    • 3-[2,4- Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner
    • Meyer, E.M., Tay, E.T., Papke, R.L. et al. 3-[2,4- Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner. Brain Res 1997, 768(1-2): 49-56.
    • (1997) Brain Res , vol.768 , Issue.1-2 , pp. 49-56
    • Meyer, E.M.1    Tay, E.T.2    Papke, R.L.3
  • 57
    • 0033626286 scopus 로고    scopus 로고
    • The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: Studies with DMXBA (GTS-21)
    • Kem, W.R. The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: Studies with DMXBA (GTS-21). Behav Brain Res 2000, 113(1-2): 169-81.
    • (2000) Behav Brain Res , vol.113 , Issue.1-2 , pp. 169-181
    • Kem, W.R.1
  • 58
    • 0033237390 scopus 로고    scopus 로고
    • AR-R17779, an alpha7 nicotinic agonist, improves learning and memory in rats
    • Levin, E.D., Bettegowda, C., Blosser, J. et al. AR-R17779, an alpha7 nicotinic agonist, improves learning and memory in rats. Behav Pharmacol 1999, 10(6-7): 675-80.
    • (1999) Behav Pharmacol , vol.10 , Issue.6-7 , pp. 675-680
    • Levin, E.D.1    Bettegowda, C.2    Blosser, J.3
  • 59
    • 2442591453 scopus 로고    scopus 로고
    • AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors
    • Van Kampen, M., Selbach, K., Schneider, R. et al. AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors. Psychopharmacology (Berl) 2004, 172(4): 375-83.
    • (2004) Psychopharmacology (Berl) , vol.172 , Issue.4 , pp. 375-383
    • Van Kampen, M.1    Selbach, K.2    Schneider, R.3
  • 60
    • 34247184782 scopus 로고    scopus 로고
    • Boess, F.G., De Vry, J., Erb, C. et al. The novel α7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2- (methoxy)phenyl]-1-benzofuran-2-carboxamide (ABBF) improves working and recognition memory in rodents. J Pharmacol Exp Ther 2007, Epub ahead of print.
    • Boess, F.G., De Vry, J., Erb, C. et al. The novel α7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2- (methoxy)phenyl]-1-benzofuran-2-carboxamide (ABBF) improves working and recognition memory in rodents. J Pharmacol Exp Ther 2007, Epub ahead of print.
  • 61
    • 0011359002 scopus 로고    scopus 로고
    • The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration
    • O'Neill, M. J., Murray, T.K., Lakics, V. et al. The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration. Curr Drug Targets CNS Neurol Disord 2002, (4): 399-411.
    • (2002) Curr Drug Targets CNS Neurol Disord , vol.4 , pp. 399-411
    • O'Neill, M.J.1    Murray, T.K.2    Lakics, V.3
  • 62
    • 0033624509 scopus 로고    scopus 로고
    • Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors
    • Wang, H.Y., Lee, D.H., Davis, C.B. et al. Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors. J Neurochem 2000, 75(3): 1155-61.
    • (2000) J Neurochem , vol.75 , Issue.3 , pp. 1155-1161
    • Wang, H.Y.1    Lee, D.H.2    Davis, C.B.3
  • 63
    • 0035836747 scopus 로고    scopus 로고
    • Beta-amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons
    • Liu, Q., Kawai, H., Berg, D.K. Beta-amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons. Proc Natl Acad Sci USA 2001, 98(8): 4734-9.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.8 , pp. 4734-4739
    • Liu, Q.1    Kawai, H.2    Berg, D.K.3
  • 64
    • 0037067717 scopus 로고    scopus 로고
    • Beta-amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes
    • Dineley, K.T., Bell, K.A., Bui, D. et al. Beta-amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Biol Chem 2002, 277(28): 25056-61.
    • (2002) J Biol Chem , vol.277 , Issue.28 , pp. 25056-25061
    • Dineley, K.T.1    Bell, K.A.2    Bui, D.3
  • 65
    • 0037151046 scopus 로고    scopus 로고
    • Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    • Dineley, K.T., Xia, X., Bui, D. et al. Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J Biol Chem 2002, 277(25): 22768-80.
    • (2002) J Biol Chem , vol.277 , Issue.25 , pp. 22768-22780
    • Dineley, K.T.1    Xia, X.2    Bui, D.3
  • 66
    • 0035957946 scopus 로고    scopus 로고
    • Alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity
    • Kihara, T., Shimohama, S., Sawada, H. et al. Alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem 2001, 276(17): 13541-6.
    • (2001) J Biol Chem , vol.276 , Issue.17 , pp. 13541-13546
    • Kihara, T.1    Shimohama, S.2    Sawada, H.3
  • 67
    • 0346460961 scopus 로고    scopus 로고
    • Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid
    • Shaw, S., Bencherif, M., Marrero, M.B. Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid. J Biol Chem 2002, 277(47): 44920-4.
    • (2002) J Biol Chem , vol.277 , Issue.47 , pp. 44920-44924
    • Shaw, S.1    Bencherif, M.2    Marrero, M.B.3
  • 68
    • 0042357192 scopus 로고    scopus 로고
    • Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation
    • Wang, H.Y., Li, W., Benedetti, N.J. et al. Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation. J Biol Chem 2003, 278(34): 31547-53.
    • (2003) J Biol Chem , vol.278 , Issue.34 , pp. 31547-31553
    • Wang, H.Y.1    Li, W.2    Benedetti, N.J.3
  • 69
    • 0036316642 scopus 로고    scopus 로고
    • Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw)
    • Nordberg, A., Hellstrom-Lindahl, E., Lee, M. et al. Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw). J Neurochem 2002, 81(3): 655-8.
    • (2002) J Neurochem , vol.81 , Issue.3 , pp. 655-658
    • Nordberg, A.1    Hellstrom-Lindahl, E.2    Lee, M.3
  • 70
    • 30744443800 scopus 로고    scopus 로고
    • Alpha7 nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in beta-amyloid infused rats
    • Chen, L., Yamada, K., Nabeshima, T. et al. Alpha7 nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in beta-amyloid infused rats. Neuropharmacology 2006, 50(2): 254-68.
    • (2006) Neuropharmacology , vol.50 , Issue.2 , pp. 254-268
    • Chen, L.1    Yamada, K.2    Nabeshima, T.3
  • 71
    • 0035470834 scopus 로고    scopus 로고
    • Intragastric DMXB-A, an alpha7 nicotinic agonist, improves deficient sensory inhibition in DBA/2 mice
    • Simosky J.K., Stevens, K.E., Kern, W.R. et al. Intragastric DMXB-A, an alpha7 nicotinic agonist, improves deficient sensory inhibition in DBA/2 mice. Biol Psychiatry 2001, 50(7): 493-500.
    • (2001) Biol Psychiatry , vol.50 , Issue.7 , pp. 493-500
    • Simosky, J.K.1    Stevens, K.E.2    Kern, W.R.3
  • 72
    • 0141993546 scopus 로고    scopus 로고
    • DMXB, an alpha7 nicotinic agonist, normalizes auditory gating in isolation-reared rats
    • O'Neill, H.C., Rieger, K., Kern, W.R. et al. DMXB, an alpha7 nicotinic agonist, normalizes auditory gating in isolation-reared rats. Psychopharmacology (Berl) 2003, 169(3-4): 332-9.
    • (2003) Psychopharmacology (Berl) , vol.169 , Issue.3-4 , pp. 332-339
    • O'Neill, H.C.1    Rieger, K.2    Kern, W.R.3
  • 74
    • 3142761435 scopus 로고    scopus 로고
    • Alpha-7 nicotinic receptor agonists: Potential new candidates for the treatment of schizophrenia
    • Martin, L.F., Kern, W.R., Freedman, R. Alpha-7 nicotinic receptor agonists: Potential new candidates for the treatment of schizophrenia. Psychopharmacology (Berl) 2004, 174(1): 54-64.
    • (2004) Psychopharmacology (Berl) , vol.174 , Issue.1 , pp. 54-64
    • Martin, L.F.1    Kern, W.R.2    Freedman, R.3
  • 75
    • 33744911665 scopus 로고    scopus 로고
    • Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia
    • Olincy, A., Harris, J.G., Johnson, L.L. et al. Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch Gen Psychiatry 2006, 63(6): 630-8.
    • (2006) Arch Gen Psychiatry , vol.63 , Issue.6 , pp. 630-638
    • Olincy, A.1    Harris, J.G.2    Johnson, L.L.3
  • 76
    • 33845719612 scopus 로고    scopus 로고
    • SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) Efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia
    • Pichat, P., Bergis, O.E., Terranova, J.P. et al. SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) Efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 2007, 32: 17-34.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 17-34
    • Pichat, P.1    Bergis, O.E.2    Terranova, J.P.3
  • 77
    • 0036170063 scopus 로고    scopus 로고
    • Effects of alpha 4/beta 2- and alpha 7-nicotine acetylcholine receptor agonists on pre-pulse inhibition of the acoustic startle response in rats and mice
    • Schreiber, R., Dalmus, M., De Vry, J. Effects of alpha 4/beta 2- and alpha 7-nicotine acetylcholine receptor agonists on pre-pulse inhibition of the acoustic startle response in rats and mice. Psychopharmacology (Berl) 2002, 159(3): 248-57.
    • (2002) Psychopharmacology (Berl) , vol.159 , Issue.3 , pp. 248-257
    • Schreiber, R.1    Dalmus, M.2    De Vry, J.3
  • 78
    • 3242889661 scopus 로고    scopus 로고
    • Nicotine blocks apomorphine-induced disruption of prepulse inhibition of the acoustic startle in rats: Possible involvement of central nicotinic alpha7 receptors
    • Suemaru, K., Yasuda, K., Umeda, K. et al. Nicotine blocks apomorphine-induced disruption of prepulse inhibition of the acoustic startle in rats: Possible involvement of central nicotinic alpha7 receptors. Br J Pharmacol 2004, 142(5): 843-50.
    • (2004) Br J Pharmacol , vol.142 , Issue.5 , pp. 843-850
    • Suemaru, K.1    Yasuda, K.2    Umeda, K.3
  • 79
    • 0034927359 scopus 로고    scopus 로고
    • Effects of smoking on acoustic startle and prepulse inhibition in humans
    • Duncan, E., Madonick, S., Chakravorty, S. et al. Effects of smoking on acoustic startle and prepulse inhibition in humans. Psychopharmacology (Berl) 2001, 156(2-3): 266-72.
    • (2001) Psychopharmacology (Berl) , vol.156 , Issue.2-3 , pp. 266-272
    • Duncan, E.1    Madonick, S.2    Chakravorty, S.3
  • 80
    • 3242678172 scopus 로고    scopus 로고
    • Nicotinic receptors and schizophrenia
    • Ripoll, N., Bronnec, M., Bourin, M. Nicotinic receptors and schizophrenia. Curr Med Res Opin 2004, 20(7): 1057-74
    • (2004) Curr Med Res Opin , vol.20 , Issue.7 , pp. 1057-1074
    • Ripoll, N.1    Bronnec, M.2    Bourin, M.3


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