Effects of Na+ channel inactivation kinetics on metabolic energy costs of action potentials

Neurocomputing

Volumn 70, Issue 10-12, 2007, Pages 1652-1656

  Crotty, Patrick ^a   Levy, William B ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Hodgkin Huxley model; Na+ K+ pump; Optimization; Sodium channel; Sodium inactivation; Sodium potassium exchanger

Indexed keywords

KINETICS; LIVING SYSTEMS STUDIES; MATHEMATICAL MODELS; NEURONS; OPTIMIZATION; SODIUM;

CHANNEL INACTIVATION KINETICS; HODGKIN-HUXLEY-TYPE MODELS; SODIUM CHANNEL; SQUID GIANT AXONS;

NEUROLOGY;

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); POTASSIUM ION; SODIUM CHANNEL; SODIUM ION;

ARTICLE; CALCULATION; CELL KINETICS; CELL METABOLISM; COMPUTER PROGRAM; CONTROLLED STUDY; ENERGY CONSUMPTION; ENERGY COST; ENERGY EXPENDITURE; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE FIBER; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SODIUM TRANSPORT; SQUID;

EID: 34247481812     PISSN: 09252312     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neucom.2006.10.063     Document Type: Article

References (16)

1. Armstrong C.M., and Bezanilla F. Inactivation of the sodium channel, II: gating current experiments. J. Gen. Physiol. 70 (1977) 567-590
2. Attwell D., and Laughlin S.B. An energy budget for signaling in the grey matter of the brain. J. Cereb. Blood Flow Metab. 21 (2001) 1133-1145
3. Crotty P., Sangrey T., and B Levy W. Metabolic energy cost of action potential velocity. J. Neurophysiol. 96 (2006) 1237-1246
4. Goldin A.L. Resurgence of sodium channel research. Annu. Rev. Physiol. 63 (2001) 871-894
5. Hille B. Ion Channels of Excitable Membranes. third ed. (2001), Sinauer Associates, Sunderland, MA
6. Hines M.L., and Carnevale N.T. The NEURON simulation environment. Neural Comput. 9 (1997) 1179-1209
7. Hodgkin A.L., and Huxley A.F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117 (1952) 500-544
8. + gradient in the oxygenated isolated heart: effect of changing the free energy of ATP hydrolysis. Am. J. Physiol. Heart Circ. Physiol. 285 (2003) H2437-H2445
9. Keynes R.D. The kinetics of voltage-gated ion channels. Q. Rev. Biophys. 27 (1994) 339-434
10. Keynes R.D., and Elinder F. Modelling the activation, opening, inactivation and reopening of the voltage-gated sodium channel. Proc. R. Soc. London B 265 (1998) 263-270
11. Laughlin S.B., and Sejnowski T.J. Communication in neuronal networks. Science 301 (2003) 1870-1874
12. B Levy W., and Baxter R.A. Energy efficient neural codes. Neural Comput. 8 (1996) 531-543
13. B Levy W., and Baxter R.A. Energy-efficient neuronal computation via quantal synaptic failures. J. Neurosci. 22 (2002) 4746-4755
14. B Levy W., Crotty P., Sangrey T.D., and Friesen W.O. Reply to Jurisic and Bezanilla's letter to the editor. J. Neurophysiol. 96 (2006) 960
15. Sangrey T.D., Friesen W.O., and B Levy W. Analysis of the optimal channel density of the squid giant axon using a reparameterized Hodgkin-Huxley model. J. Neurophysiol. 91 (2004) 2541-2550
16. Vandenberg C.A., and Bezanilla F. A sodium channel gating model based on single channel, macroscopic, and gating currents in the squid giant axon. Biophys. J. 60 (1991) 1511-1533