Alpha-T-catenin (CTNNA3) displays tumour specific monoallelic expression in urothelial carcinoma of the bladder

Genes Chromosomes and Cancer

Volumn 46, Issue 6, 2007, Pages 587-593

  Meehan, Maria ^a   Melvin, Audrey ^a   Gallagher, Emma ^a   Smith, James ^a   Mc Goldrick, Alo ^a   Moss, Catherine ^a   Goossens, Steven ^b,c   Harrison, Michèle ^d   Kay, Elaine ^e   Fitzpatrick, John ^d   Dervan, Peter ^d   Mc Cann, Amanda ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

^d MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^e BEAUMONT HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; DNA;

ARTICLE; BLADDER CARCINOMA; CELL ADHESION; CONTROLLED STUDY; CTNNA3 GENE; EXON; GENE EXPRESSION; GENE FREQUENCY; GENOME IMPRINTING; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; LAMINA PROPRIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE; UROGENITAL TRACT TUMOR;

ALPHA CATENIN; CARCINOMA; CELL LINE; COHORT STUDIES; FEMALE; GENE FREQUENCY; GENOMIC IMPRINTING; HETEROZYGOTE; HUMANS; MALE; NEOPLASM STAGING; RISK; URINARY BLADDER NEOPLASMS;

EID: 34247481333     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20443     Document Type: Article

References (12)

1. American Joint Committee on Cancer (AJCC). 1998. Manual for Staging Of Cancer, 3rd ed. Philadelphia: JB Lippincott. 197 p.
2. Ariel I, Sughayer M, Fellig Y, Pizov G, Ayesh S, Podeh D, Libdeh BA, Levy C, Birman T, Tykocinski ML, de Groot N, Hochberg A. 2000. The imprinted H19 gene is a marker of early recurrence in human bladder carcinoma. Mol Pathol 53:320-323.
3. Gontero P, Banisadr S, Frea B, Brausi M. 2004. Metastasis markers in bladder cancer: A review of the literature and clinical considerations. Eur Urol 46:296-311.
4. Goossens S, Janssens B, Vanpoucke G, De Rycke R, van Hengel J, van Roy F. 2007. Truncated isoform of mouse αT-catenin is testes restricted in expression and function. FASEB J 3:647-655.
5. Janssens B, Goossens S, Staes K. Gilbert B, van Hengel J, Colpaert C, Bruyneel E, Mareel M, van Roy F. 2001. αT-catenin: A novel tissue-specific β-catenin-binding protein mediating strong cell-cell adhesion. J Cell Sci 114:3177-3188.
6. Janssens B, Mohapatra B, Vatta M, Goossens S, Vanpoucke G, Kools P, Montoye T, van Hengel J, Bowles NE, van Roy F, Towbin JA. 2003. Assessment of the CTNNA3 gene encoding human αT-catenin regarding itsinvolvement in dilated cardiomyopathy. Hum Genet 112:227-236.
7. Lauren J, Airaksinen MS, Saarma M, Timmusk T. 2003. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics 81:411-421.
8. Mostofi FK. 1973. Histological typing of urinary bladder tumours. In: International Classification of tumours, No. 10. Geneva: World Health Organisation.
9. Peinado H, Portillo F, Cano A. 2004. Transcriptional regulation of cadherins during development and carcinogenesis. Int J Dev Biol 48:365-375.
10. Thiery JP. 2002. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2:442-454.
11. Van Dijk M, Mulders J, Konst A, Janssens B, van Roy F, Blankenstein M, Oudejans C. 2004. Differential downregulation of αT-catenin expression in placenta: Trophoblast cell type-dependent imprinting of the CTNNA3 gene. Gene Expr Patterns 5:61-65.
12. Williams SG, Stein JP. 2004. Molecular pathways in bladder cancer. Urol Res 6:373-385.