Dexamethasone does not alter in vitro antibacterial efficacy of gentamicin

Otolaryngology - Head and Neck Surgery

Volumn 136, Issue 5, 2007, Pages 769-772

  Drobbin, Michael T ^a   Phelan, Sean T ^a   Antonelli, Patrick J ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GENTAMICIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONCENTRATION (PARAMETERS); DILUTION; DRUG EFFICACY; IN VITRO STUDY; MICROBIOLOGY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; DRUG ADMINISTRATION SCHEDULE; GENTAMICINS; HUMANS; OTITIS MEDIA; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 34247468383     PISSN: 01945998     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.otohns.2006.11.015     Document Type: Article

References (23)

1. Mascaretti O. Bacteria Versus Antibacterial agents: an integrated approach (2003), ASM Press, Washington, DC 229-333
2. Chambers H.F. The aminoglycosides. In: Hardman J.G., Limbird L.E., and Gilman A.G. (Eds). Goodman & Gilman's the pharmacological basis of therapeutics (2001), McGraw-Hill, New York 1219-1238
3. Himeno C., Komeda M., Izumikawa M., et al. Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig. Hear Res 167 (2002) 61-70
4. Park S.K., Choi D., Russell P., et al. Protective effect of corticosteroid against the cytotoxicity of aminoglycoside otic drops on isolated cochlear outer hair cells. Laryngoscope 114 (2004) 768-771
5. Kawana M., Kawana C., and Giebink G.S. Penicillin treatment accelerates middle ear inflammation in experimental pneumococcal otitis media. Infect Immun 60 (1992) 1908-1912
6. Park S.N., and Yeo S.W. Effects of antibiotics and steroid on middle ear mucosa in rats with experimental acute otitis media. Acta Otolaryngol 121 (2001) 808-812
7. Chan Y.M., Adams D.A., and Kerr A.G. Syphilitic labyrinthitis-an update. J Laryngol Otol 109 (1995) 719-725
8. Rappaport J.M., Bhatt S.M., Burkard R.F., et al. Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac. J Infect Dis 179 (1999) 264-268
9. Hartnick C.J., Kim H.Y., Chute P.M., et al. Preventing labyrinthitis ossificans: the role of steroids. Arch Otolaryngol Head Neck Surg 127 (2001) 180-183
10. Li Z., Li R., Chen J., et al. Mutational analysis of the mitochondrial 12S rRNA gene in Chinese pediatric subjects with aminoglycoside-induced and non-syndromic hearing loss. Hum Genet 117 (2005) 9-15
11. Guan M.X. Molecular pathogenetic mechanism of maternally inherited deafness. Ann N Y Acad Sci 1011 (2004) 259-271
12. NCCLS methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard. 6th ed. (2003), National Committee for Clinical Laboratory Standards, Wayne, PA
13. Loew D., Schuster O., and Graul E.H. Dose-dependent pharmacokinetics of dexamethasone. Eur J Clin Pharmacol 30 (1986) 225-230
14. Toth G.G., Kloosterman C., Uges D.R., et al. Pharmacokinetics of high-dose oral and intravenous dexamethasone. Ther Drug Monit 21 (1999) 532-535
15. Moore R.D., Smith C.R., and Lietman P.S. Risk factors for the development of auditory toxicity in patients receiving aminoglycosides. J Infect Dis 149 (1984) 23-30
16. Plotkin B.J., Roose R.J., Erikson Q., et al. Effect of androgens and glucocorticoids on microbial growth and antimicrobial susceptibility. Curr Microbiol 47 (2003) 514-520
17. Caronzolo D., Lucini V., Pannacci M., et al. Glucocorticoids increase in vitro and in vivo activities of antibiotics against Chlamydophila pneumoniae. Antimicrob Agents Chemother 48 (2004) 4878-4881
18. Bode H.B., and Muller R. Possibility of bacterial recruitment of plant genes associated with the biosynthesis of secondary metabolites. Plant Physiol 132 (2003) 1153-1161
19. Roland P.S., Kreisler L.S., Reese B., et al. Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tubes. Pediatrics 113 (2004) 40-46
20. Pitcairn M., Schuler J., Erve P.R., et al. Glucocorticoid and antibiotic effect on experimental gram-negative bacteremic shock. Arch Surg 110 (1975) 1012-1015
21. Weisfelt M., van de Beek D., and de Gans J. Dexamethasone treatment in adults with pneumococcal meningitis: risk factors for death. Eur J Clin Microbiol Infect Dis 25 (2006) 73-78
22. Neuwelt E.A., Lawrence M.S., and Blank N.K. Effect of gentamicin and dexamethasone on the natural history of the rat Escherichia coli brain abscess model with histopathological correlation. Neurosurgery 15 (1984) 475-483
23. Cabellos C., Martinez-Lacasa J., Tubau F., et al. Evaluation of combined ceftriaxone and dexamethasone therapy in experimental cephalosporin-resistant pneumococcal meningitis. J Antimicrob Chemother 45 (2000) 315-320