The pharmacokinetic behavior of the photosensitizer meso-tetra- hydroxyphenyl-chlorin in mice and men

Cancer Chemotherapy and Pharmacology

Volumn 60, Issue 1, 2007, Pages 113-122

  Triesscheijn, Martijn ^a   Ruevekamp, Marjan ^a   Out, Ruud ^b   Van Berkel, Theo J C ^b   Schellens, Jan ^a,c   Baas, Paul ^a   Stewart, Fiona A ^a  

^a ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Lipoproteins; Mice; mTHPC; Patients; Pharmacokinetics; Photodynamic therapy

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; MESO TETRA HYDROXYPHENYLCHLORIN; PHOTOSENSITIZING AGENT; TEMOPORFIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BASAL CELL CARCINOMA; CANCER PATIENT; CHOLESTEROL METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; FEMALE; HEAD AND NECK CARCINOMA; HUMAN; LIPOPROTEIN METABOLISM; MAXIMUM PLASMA CONCENTRATION; MOUSE; MOUTH CARCINOMA; NONHUMAN; NUDE MOUSE; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; STEADY STATE; TRANSGENIC MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOLIPOPROTEINS E; AREA UNDER CURVE; CARCINOMA, BASAL CELL; CARCINOMA, SQUAMOUS CELL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HALF-LIFE; HEAD AND NECK NEOPLASMS; HUMANS; INJECTIONS, INTRAVENOUS; LIPOPROTEINS; LIPOPROTEINS, HDL; LIPOPROTEINS, VLDL; MESOPORPHYRINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEOPLASMS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; SCAVENGER RECEPTORS, CLASS B; SPECIES SPECIFICITY; TISSUE DISTRIBUTION;

EID: 34247392783     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-006-0356-9     Document Type: Article

References (22)

1. Allison BA, Pritchard PH, Richter AM, Levy JG (1990) The plasma distribution of benzoporphyrin derivative and the effects of plasma lipoproteins on its biodistribution. Photochem Photobiol 52:501-507
2. Blant SA, Glanzmann TM, Ballini JP, Wagnieres G, Van den Bergh H, Monnier P (2002) Uptake and localisation of mTHPC (Foscan) and its 14C-labelled form in normal and tumour tissues of the hamster squamous cell carcinoma model: a comparative study. Br J Cancer 87:1470-1478
3. Braichotte D, Savary JF, Glanzmann T, Westermann P, Folli S, Wagnieres G, Monnier P, Van den Bergh H (1995) Clinical pharmacokinetic studies of tetra(meta-hydroxyphenyl)chlorin in squamous cell carcinoma by fluorescence spectroscopy at 2 wavelengths. Int J Cancer 63:198-204
4. Buchholz J, Kaser-Hotz B, Khan T, Rohrer Bley C, Melzer K, Schwendener RA, Roos M, Walt H (2005) Optimizing photodynamic therapy: in vivo pharmacokinetics of liposomal meta-(tetrahydroxyphenyl)chlorin in feline squamous cell carcinoma. Clin Cancer Res 11:7538-7544
5. Campbell GA, Bartels KE, Arnold C, Healey T, Cowell RL, Lucroy MD, Ronn AM (2002) Tissue levels, histologic changes and plasma pharmacokinetics of meta-tetra (hydroxyphenyl) chlorin (mTHPC) in the cat. Lasers Med Sci 17:79-85
6. Cramers P, Ruevekamp M, Oppelaar H, Dalesio O, Baas P, Stewart FA (2003) Foscan uptake and tissue distribution in relation to photodynamic efficacy. Br J Cancer 88:283-290
7. Glanzmann T, Hadjur C, Zellweger M, Grosiean P, Forrer M, Ballini JP, Monnier P, Van den Bergh H, Lim CK, Wagnieres G (1998) Pharmacokinetics of tetra(m-hydroxyphenyl) chlorin in human plasma and individualized light dosimetry in photodynamic therapy. Photochem Photobiol 67:596-602
8. Hopkinson HJ, Vernon DI, Brown SB (1999) Identification and partial characterization of an unusual distribution of the photosensitizer meta-tetrahydroxyphenyl chlorin (temopor-fin) in human plasma. Photochem Photobiol 69:482-488
9. Jones HJ, Vernon DI, Brown SB (2003) Photodynamic therapy effect of m-THPC (Foscan) in vivo: correlation with pharmacokinetics. Br J Cancer 89:398-404
10. Jori G, Reddi E (1993) The role of lipoproteins in the delivery of tumour-targeting photosensitizers. Int J Biochem 25:1369-1375
11. Kessel D (1986) Porphyrin-lipoprotein association as a factor in porphyrin localization. Cancer Lett 33:183-188
12. Kessel D (1999) Transport and localisation of m-THPC in vitro. Int J Clin Pract 53:263-267
13. Kongshaug M, Moan J, Brown SB (1989) The distribution of porphyrins with different tumour localising ability among human plasma proteins. Br J Cancer 59:184-188
14. Maugain E, Sasnouski S, Zorin V, Merlin JL, Guillemin F, Bezdetnaya L (2004) Foscan-based photodynamic treatment in vivo: correlation between efficacy and Foscan accumulation in tumor, plasma and leukocytes. Oncol Rep 12:639-645
15. Michael-Titus AT, Whelpton R, Yaqub Z (1995) Binding of temoporfin to the lipoprotein fractions of human serum. Br J Clin Pharmacol 40:594-597
16. Mitra S, Foster TH (2005) Photophysical parameters, photosensitizer retention and tissue optical properties completely account for the higher photodynamic efficacy of meso-tetrahydroxyphenyl-chlorin vs photofrin. Photochem Photobiol 81:849-859
17. Ris HB, Altermatt HJ, Inderbitzi R, Hess R, Nachbur B, Stewart JC, Wang Q, Lim CK, Bonnett R, Berenbaum MC, Althaus U (1991) Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. Br J Cancer 64:1116-1120
18. Ronn AM, Nouri M, Lofgren LA, Steinberg BM, Westerborn A, Windahl T, Shikowitz MJ, Abramson AL (1996) Human tissue levels and plasma pharmacokinetics of temoporfin (Foscan, mTHPC). Lasers Med Sci 11:267-272
19. Sasnouski S, Zorin V, Khludeyev I, D'Hallewin MA, Guillemin F, Bezdetnaya L (2005) Investigation of Foscan interactions with plasma proteins. Biochim Biophys Acta 1725:394-402
20. Triesscheijn M, Ruevekamp M, Aalders M, Baas P, Stewart FA (2005) Outcome of mthpc mediated photodynamic therapy is primarily determined by the vascular response. Photochem Photobiol 81:1161-1167
21. Whelpton R, Michael-Titus AT, Basra SS, Grahn M (1995) Distribution of temoporfin, a new photosensitizer for the photodynamic therapy of cancer, in a murine tumor model. Photochem Photobiol 61:397-401
22. Whelpton R, Michael-Titus AT, Jamdar RP, Abdillahi K, Grahn MF (1996) Distribution and excretion of radiolabeled temoporfin in a murine tumor model. Photochem Photobiol 63:885-891