N-Acetylcysteine for the prevention of renal dysfunction in high-risk patients undergoing coronary bypass graft surgery: An unfulfilled promise?

Critical Care Medicine

Volumn 35, Issue 5, 2007, Pages 1431-1433

  Filep, János G ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Acute renal failure; Cardiopulmonary bypass surgery; N acetylcysteine; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; CONTRAST MEDIUM; CREATININE; CYSTATIN C; PLACEBO; REACTIVE OXYGEN METABOLITE;

ACUTE KIDNEY FAILURE; ANAPHYLAXIS; CLINICAL TRIAL; CORONARY ARTERY BYPASS GRAFT; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DIALYSIS; DOSE RESPONSE; DRUG MECHANISM; DRUG MEGADOSE; DRUG WITHDRAWAL; EDITORIAL; HEART LEFT VENTRICLE FUNCTION; HEMODIALYSIS; HIGH RISK PATIENT; HUMAN; INTENSIVE CARE UNIT; MORBIDITY; MORTALITY; OBESITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; STATISTICAL SIGNIFICANCE;

ACETYLCYSTEINE; CARDIAC SURGICAL PROCEDURES; FREE RADICAL SCAVENGERS; HUMANS; KIDNEY; KIDNEY FAILURE, ACUTE; TREATMENT OUTCOME;

EID: 34247390563     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000262935.07807.9B     Document Type: Editorial

References (20)

1. Mangano CM, Diamondstone LS, Ramsay JG, et al: Renal dysfunction after myocardial revascularization: Risk factors, adverse outcomes, and hospital resource utilization. The Multicenter Study of Perioperative Ischemia Research Group. Ann Intern Med 1998; 128: 194-203
2. Bhat JG, Gluck MC, Lowenstein J, et al: Renal failure after open heart surgery. Ann Intern Med 1976; 84:677-682
3. Abel RM, Buckley MJ, Austen WG, et al: Etiology, incidence, and prognosis of renal failure following cardiac operations: Results of a prospective analysis of 500 consecutive patients. J Thorac Cardiovasc Surg 1976; 71: 323-333
4. Chertow GM, Lazarus JM, Christiansen CL, et al: Preoperative renal risk stratification. Circulation 1997; 95:878-884
5. Thakar CV, Liangos O, Yared JP, et al: Predicting acute renal failure after cardiac surgery: Validation and redefinition of a risk stratification algorithm. Hemodial Int 2003; 7:143-147
6. Loef BG, Epema AH, Smilde TD, et al: Immediate postoperative renal function deterioration in cardiac surgical patients predicts in-hospital mortality and long-term survival. J Am Soc Nephrol 2005; 16:195-200
7. Chertow GM, Levy EM, Hemmermeister KE, et al: Independent association between acute renal failure and mortality following cardiac surgery. Am J Med 1998; 104:343-348
8. Baliga R, Ueda N, Walker PD, et al: Oxidant mechanisms in toxic acute renal failure. Am J Kidney Dis 1997; 29:465-477
9. Spies CD, Reinhart K, Witt I, et al: Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: Results from a prospective, randomized, double-blind study. Crit Care Med 1994; 22:1738-1746
10. Tepel M, van der Giet M, Schwarzfeld C, et al: Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 2000; 343:180-184
11. Birck R, Krzossok S, Markowetz F, et al: Acetylcysteine for prevention of contrast nephropathy: Meta-analysis. Lancet 2003; 362: 598-603
12. Isenbarger DW, Kent SM, O'Malley PG: Meta-analysis of randomized clinical trials on the usefulness of acetylcysteine for prevention of contrast nephropathy. Am J Cardiol 2003; 92:1454-1458
13. Efrati S, Dishi V, Averbukh M, et al: The effect of N-acetylcysteine on renal function, nitric oxide, and oxidative stress after angiography. Kidney Int 2003; 64:2182-2187
14. Kshirsagar AV, Poole C, Mottl A, et al: N-acetylcysteine for the prevention of radiocontrast induced nephropathy: A meta-analysis of prospective controlled trials. J Am Soc Nephrol 2004; 15:761-769
15. Fischer UM, Tossios P, Mehlhorn U: Renal protection by radical scavenging in cardiac surgery patients. Curr Med Res Opin 2005; 21:1161-1164
16. Burns KEA, Chu MWA, Novick RJ, et al: Perioperative N-acetylcysteine to prevent renal dysfunction in high-risk patients undergoing CABG surgery: A randomized controlled trial. JAMA 2005; 294:342-350
17. Haase M, Haase-Fielitz A, Bagshaw SM, et al: Phase II, randomized, controlled trial of highdose N-acetylcysteine in high-risk cardiac surgery patients. Crit Care Med 2007; 35:1324-1331
18. Dhamidharka VR, Kwon C, Stevens G: Serum cystatin C is superior to serum creatinine as a marker of kidney function: A meta-analysis. Am J Kidney Dis 2002; 40:221-226
19. Boldt J, Brosch C, Piper SN, et al: Influence of prophylactic use of pentoxifylline on postoperative organ dysfunction in elderly cardiac surgery patients. Crit Care Med 2001; 29:952-958
20. Bergman AS, Odar-Cederlof I, Westman L, et al: Diltiazem infusion for renal protection in cardiac surgical patients with preexisting renal dysfunction. J Cardiothorac Vasc Anesth 2002; 16:294-299