Intra-erythrocyte cation concentrations in relation to the C1797T β-adducin polymorphism in a general population

Journal of Human Hypertension

Volumn 21, Issue 5, 2007, Pages 387-392

  Richart, T ^a   Thijs, L ^a   Kuznetsova, T ^a   Tikhonoff, V ^a,b   Zagato, L ^c   Lijnen, P ^a   Fagard, R ^a   Wang, J ^d   Bianchi, G ^c   Staessen, J A ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF PADOVA   (Italy)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^d SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADDUCIN; BETA ADDUCIN; CALCIUM ION; CATION; CYTOSINE; CYTOSKELETON PROTEIN; GLYCINE; MAGNESIUM ION; POTASSIUM ION; SODIUM ION; THYMIDINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ADULT; AGE; ALCOHOL CONSUMPTION; ARTICLE; BLOOD PRESSURE REGULATION; CALCIUM BLOOD LEVEL; CALCIUM URINE LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ERYTHROCYTE COUNT; ERYTHROCYTE FRAGILITY; ERYTHROCYTE LEVEL; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HEMATOCRIT; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; HYPERTENSION; MAGNESIUM BLOOD LEVEL; MAGNESIUM URINE LEVEL; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; POTASSIUM BLOOD LEVEL; POTASSIUM URINE LEVEL; SEX DIFFERENCE; SODIUM BLOOD LEVEL; SODIUM URINE LEVEL;

ADULT; BELGIUM; BIOLOGICAL MARKERS; BLOOD PRESSURE; CALCIUM; CALMODULIN-BINDING PROTEINS; CATIONS; ERYTHROCYTE MEMBRANE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; MAGNESIUM; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; POTASSIUM; REGRESSION ANALYSIS; RESEARCH DESIGN; SENSITIVITY AND SPECIFICITY; SEX FACTORS; SODIUM;

EID: 34247374647     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/sj.jhh.1002154     Document Type: Article

References (19)

1. Muro AF, Marro ML, Gajovic S, Porro F, Luzzatto L, Baralle FE. Mild spherocytic hereditary elliptocytosis and altered levels of α- and γ-adducins in β-adducin-deficient mice. Blood 2000; 95: 3978-3985.
2. Porro F, Costessi L, Marro M, Baralle F, Muro A. The erythrocyte skeletons of beta-adducin deficient mice have altered levels of tropomyosin, tropomodulin and EcapZ. FEBS Lett 2004; 576: 36-40.
3. Castejon AM, Alfieri AB, Hoffmann IS, Rathinavelu A, Cubeddu LX. Alpha-adducin polymorphism, salt sensitivity, nitric oxide excretion, and cardiovascular risk factors in normotensive Hispanics. Am J Hypertens 2003; 16: 1018-1024.
4. Tikhonoff V, Kuznetsova T, Stolarz K, Bianchi G, Casiglia E, Kawecka-Jaszcz K et al. B-adducin polymorphisms, blood pressure, and sodium excretion in three European population. Am J Hypertens 2003; 20: 840-846.
5. Wang JG, Barlassina C, Bianchi G, Fagard R, Zagato L, Staessen JA. Haematological phenotypes in relation to the C1797T β-adducin polymorphism in a Caucasian population. Clin Sci 2003; 104: 369-376.
6. Lew V, Tiffert T, Etzion Z, Perdomo D, Daw N, MacDonald L et al. Distribution of dehydration rates generated by maximal Gardos-channel activation in normal and sickle red blood cells. Blood 2005; 105: 361-367.
7. Staessen AJ, Roels H, Emelianov D, Vangronsveld J, Kuznetsova T, Thijs L et al. Environmental exposure to cadmium, forearm bone density, and risk of fractures: Prospective population study. Lancet 1999; 353: 1140-1144.
8. Staessen AJ, Fagard R, Amery A. Life style as a determinant of blood pressure in the general population, Am J Hypertens 1994; 7: 685-694.
9. Livak KJ, Flood SJ, Marmaro J, Giusti W, Deetz K. Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization. PCR Methods App 1995; 4: 357-362.
10. a C825T polymorphism. J Hypertens 2003; 21, 729-737.
11. Tripodi G, Casari G, Tisminetzky S, Bianchi G, Devescovi G, Muro A et al. Characterisation and chromosomal localisation of the rat α- and β-adducin-encoding genes. Gene 1995; 166: 307-311.
12. Glorioso N, Filigheddu F, Troffa C, Soro A, Parpaglia PP, Tsikoudakis A et al. Interaction of the α1-Na, K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension. Hypertension 2001; 38: 204-209.
13. Castejon AM, Alfieri AB, Hoffmann IS, Rathinavelu A, Cubeddu LX. Alpha-adducin polymorphism, salt sensitivity, nitric oxide excretion, and cardiovascular risk factors in normotensive Hispanics. Am J Hypertens 2003; 16: 1018-1024.
14. Barlassina C, Norton GR, Samani NJ, Woodwiss AJ, Candy GC, Radevski I et al. Adducin polymorphism in hypertensives of South African ancestry. Am J Hypertens 2000; 13: 719-723.
15. Glorioso N, Filligheddu F, Cusi D, Troffa C, Conti M, Natalizio M et al. adducin 460Trp allele is associated with erythrocyte Na transport in North Sardinian primary hypertensives. Hypertension 2002; 39 part 2): 357-362.
16. Gardos G. The function of calcium in the potassium permeability of human erythrocytes. Biochim Biophys Acta 1958; 30: 653-654.
17. Lew V, Ferreira H. Calcium Transport and the Properties of a Calcium-Activated Potassium Channel in Red Cell Membranes 1978. Academic Press: London, UK.
18. Resnick LM, Gupta RK, Laragh JH. Intracellular free magnesium in eythrocytes of essential hypertension: Relation to blood pressure and serum divalent cations. Proc Natl Acad Sci USA 1984; 81: 6511-6515.
19. Simons TJ. Calcium-dependent potassium exchange in human red cell ghosts. J Physiol 1976; 256: 227-244.