Serum ionized magnesium and calcium levels in adult patients with seizures

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 67, Issue 3, 2007, Pages 317-326

  Sinert, R ^a,b   Zehtabchi, S ^a   Desai, S ^a   Peacock, P ^a   Altura, B T ^a   Altura, B M ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b SUNY Downstate Medical Center   (United States)

Author keywords

Ionized calcium; Ionized magnesium; Seizure

Indexed keywords

CALCIUM; ETIRACETAM; GABAPENTIN; MAGNESIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OXCARBAZEPINE; PHENYTOIN; TOPIRAMATE; VALPROIC ACID;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CALCIUM BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; EMERGENCY WARD; FEMALE; FISHER EXACT TEST; HUMAN; ION SELECTIVE ELECTRODE; MAGNESIUM BLOOD LEVEL; MALE; PRIORITY JOURNAL; SEIZURE; STATISTICAL SIGNIFICANCE;

ADULT; ANTICONVULSANTS; CALCIUM; FEMALE; HUMANS; ION-SELECTIVE ELECTRODES; IONS; MAGNESIUM; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REFERENCE VALUES; SEIZURES;

EID: 34247366009     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510601051441     Document Type: Article

References (44)

1. Schachter SC. Iatrogenic seizures. Neurol Clin 1998;16:157-70.
2. Gutierrez-Delicado E, Serratosa JM. Genetics of the epilepsies. Curr Opin Neurol 2004;17:147-53.
3. Krumholz A, Grufferman S, Orr ST, Stern BJ. Seizures and seizure care in an emergency department. Epilepsia 1989;30:175-81.
4. Placidi F, Floris R, Bozzao A, Romigi A, Baviera ME, Tombini M, et al. Ketotic hyperglycemia and epilepsia partialis continua. Neurology 2001;57:534-7.
5. Schwechter EM, Veliskova J, Velisek L. Correlation between extracellular glucose and seizure susceptibility in adult rats. Ann Neurol 2003;53:91-101.
6. Frucht MM, Quigg M, Schwaner C, Fountain NB. Distribution of seizure precipitants among epilepsy syndromes. Epilepsia 2000;41:1534-9.
7. Spector S, Cull C, Goldstein LH. Seizure precipitants and perceived self-control of seizures in adults with poorly-controlled epilepsy. Epilepsy Res 2000;38:207-16.
8. Ault B, Evans RH, Francis AA, Oakes DJ, Watkins JC. Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations. J Physiol 1980;307:413-28.
9. Hallak M. Effect of parenteral magnesium sulfate administration on excitatory amino acid receptors in the rat brain. Magnes Res 1998;11:117-31.
10. Mathern GW, Pretorius JK, Mendoza D, Lozada A, Leite JP, Chimelli L, et al. Increased hippocampal AMPA and NMDA receptor subunit immunoreactivity in temporal lobe epilepsy patients. J Neuropathol Exp Neurol 1998;57:615-34.
11. Mikuni N, Babb TL, Ying Z, Najm I, Nishiyama K, Wylie C, et al. NMDA-receptors 1 and 2A/B coassembly increased in human epileptic focal cortical dysplasia. Epilepsia 1999;40:1683-7.
12. MacDermott AB, Mayer ML, Westbrook GL, Smith SJ, Barker JL. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 1986;321:519-22.
13. DeLorenzo RJ, Limbrick DD, Jr. Effects of glutamate on calcium influx and sequestration/extrusion mechanisms in hippocampal neurons. Adv Neurol 1996;71:37-46.
14. DeLorenzo RJ. A molecular approach to the calcium signal in brain: relationship to synaptic modulation and seizure discharge. Adv Neurol 1986;44:435-64.
15. Heinemann U, Hamon B. Calcium and epileptogenesis. Exp Brain Res 1986;65:1-10.
16. Chaistitwanich R, Mahoney AW, Hendricks DG, Sisson DV. Dietary calcium and phosphorus and seizure susceptibility of magnesium-deficient rats. Pharmacol Biochem Behav 1987;27:443-9.
17. Powers RD. Serum chemistry abnormalities in adult patients with seizures. Ann Emerg Med 1985;14:416-20.
18. Nypaver MM, Reynolds SL, Tanz RR, Davis AT. Emergency department laboratory evaluation of children with seizures: dogma or dilemma? Pediatr Emerg Care 1992;8:13-6.
19. 2+ ratio. Headache 1993;33:135-8.
20. 2+. Scand J Clin Lab Invest 1994;Suppl 217:77-81.
21. Resnick LM, Altura BT, Gupta RK, Laragh JH, Alderman MH, Altura BM. Intracellular and extracellular magnesium depletion in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1993;36:767-70.
22. Altura BT, Altura BM. Measurement of ionized magnesium in whole blood, plasma and serum with a new ion-selective electrode in healthy and diseased human subjects. Magnes Trace Elem 1991;10:90-8.
23. Altura BT, Shirey TL, Young CC, Dell'Orfano K, Hiti J, Welsh R, et al. Characterization of a new ion selective electrode for ionized magnesium in whole blood, plasma, serum, and aqueous samples. Scand J Clin Lab Invest 1994;Suppl 217:21-36.
24. Kulpmann WR, Dreier M. Drug interferences in the measurement of ionized magnesium in serum. In: D'Orazio P, Fogh-Andersen N, Larsson L, editors. The confluence of critical care analysis and near patient testing. Madison, Wisconsin, USA: Omnipress; 1988. p 380.
25. Pavel O, Ghiran V, Muschevici D, Benga G. Plasma and cerebrospinal fluid concentrations of magnesium in epileptic children. J Neurol Sci 1985;67:29-34.
26. Sood AK, Handa R, Malhotra RC, Gupta BS. Serum, CSF, RBC & urinary levels of magnesium & calcium in idiopathic generalised tonic clonic seizures. Indian J Med Res 1993;98:152-4.
27. Blyth A, Stewart MJ. Serum magnesium levels in patients treated with phenytoin. Clin Chim Acta 1975;62:305-8.
28. Katz SH, Gerstman I, Lautenbacher HW, Hediger ML. Failure to confirm anticonvulsant hypomagnesemia [letter]. Br Med J 1976;1:341.
29. Christiansen C, Nielsen SP, Rodbro P. Anticonvulsant hypomagnesemia [letter]. Br Med J 1974;1:198-9.
30. Altura BM, Lewenstom A. Unique magnesium ion selective electrodes. Scand J Clin Lab Invest 1994;Suppl 54:1-100.
31. Seiler HG, Sigel A. Determination of magnesium in biological materials. In: Sigel H, Sigel A, editors. Metal ions in biological systems. Vol. 26. New Jersey: Marcel Dekker; 1990. pp 611-24.
32. Bock JL, Crull GB, Wishnia A, Springer CS, Jr. 25Mg NMR studies of magnesium binding to erythrocyte constituents. J Inorg Biochem 1991;44:79-87.
33. 2+ preparation and use of radiotracers in magnesium physiology oriented studies. In: Lasserre B, Durlach J, editors. Magnesium: a relevant ion. London: John Libbey; 1992. pp 299-306.
34. Mota De Freitas D, Douris E. Techniques for measuring magnesium in tissues from hypertensive, psychotic, and neurological patients. In: Birch NJ, editor. Magnesium and the cell. London: John Libbey; 1993. pp 51-79.
35. 2+ in vascular smooth muscle cells during dietary magnesium deficiency in rat. Magnes Res 1996;9:101-8.
36. Altura BM. Introduction: importance of Mg in physiology and medicine and the need for ion selective electrodes. Scand J Clin Lab Invest 1994; Suppl 217:5-9.
37. Goldman RS, Finkbeiner SM. Therapeutic use of magnesium sulfate in selected cases of cerebral ischemia and seizure. N Engl J Med 1988;319:1224-5.
38. Herron CE, Lester RA, Coan EJ, Collingridge GL. Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism. Nature 1986;322:265-8.
39. Harris EW, Ganong AH, Cotman CW. Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors. Brain Res 1984;323:132-7.
40. Hardingham GE, Arnold FJ, Bading H. A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. Nat Neurosci 2001;4:565-6.
41. 2+ in acutely isolated hippocampal CA1 pyramidal cells of the guinea-pig. Brain Res 1996;728:204-8.
42. Altura BT, Memon ZI, Zhang A, Cheng TP, Silverman R, Cracco RQ, et al. Low levels of serum ionized magnesium are found in patients early after stroke which result in rapid elevation in cytosolic free calcium and spasm in cerebral vascular muscle cells. Neurosci Lett 1997;230:37-40.
43. Memon ZI, Altura BT, Benjamin JL, Cracco RQ, Altura BM. Predictive value of serum ionized but not total magnesium levels in head injuries. Scand J Clin Lab Invest 1995;55:671-7.
44. Mauskop A, Altura BT, Cracco RQ, Altura BM. Intravenous magnesium sulphate relieves migraine attacks in patients with low serum ionized magnesium levels: a pilot study. Clin Sci (Lond) 1995;89:633-6.