메뉴 건너뛰기




Volumn 5, Issue 1, 2007, Pages 13-21

Efficacy and safety of ezetimibe/simvastatin versus simvastatin monotherapy in hypercholesterolemic patients with metabolic syndrome

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; C REACTIVE PROTEIN; EZETIMIBE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; SIMVASTATIN; TRIACYLGLYCEROL;

EID: 34247355021     PISSN: 15404196     EISSN: None     Source Type: Journal    
DOI: 10.1089/met.2006.0033     Document Type: Article
Times cited : (8)

References (24)
  • 1
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey
    • Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002;287:356-359.
    • (2002) JAMA , vol.287 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 2
    • 0035897696 scopus 로고    scopus 로고
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Executive Summary of the Third Report of the National Cholesterol Education Program NCEP
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) JAMA 2001;285:2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 3
    • 3142729178 scopus 로고    scopus 로고
    • Grundy SM, Cleeman JI, Merz CNB, Brewer Jr. HB, Clark LT, Hunninhake DB, Pasternak RC, Smith Jr. SC, Stone NJ, for the Coordinating Committee of the National Cholesterol Education Program. NCEP Report. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Circulation 2004;110:227-239.
    • Grundy SM, Cleeman JI, Merz CNB, Brewer Jr. HB, Clark LT, Hunninhake DB, Pasternak RC, Smith Jr. SC, Stone NJ, for the Coordinating Committee of the National Cholesterol Education Program. NCEP Report. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Circulation 2004;110:227-239.
  • 5
    • 2342574933 scopus 로고    scopus 로고
    • Efficacy and safety of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia: A randomized, double-blind, placebo-controlled trial
    • Goldberg AC, Sapre A, Liu J, Capece R, Mitchel YB. Efficacy and safety of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia: a randomized, double-blind, placebo-controlled trial. Mayo Clin Proc 2004;79:620-629.
    • (2004) Mayo Clin Proc , vol.79 , pp. 620-629
    • Goldberg, A.C.1    Sapre, A.2    Liu, J.3    Capece, R.4    Mitchel, Y.B.5
  • 6
    • 11844291388 scopus 로고    scopus 로고
    • Ezetimibe Study Group. A multicenter, randomized, double-blind, placebo-controlled, factorial design study to evaluate the lipid-altering efficacy and safety profile of the ezetimibe/simvastatin tablet compared with ezetimibe and simvastatin monotherapy in patients with primary hypercholesterolemia
    • Bays HE, Ose L, Fraser N, Tribble DL, Quinto K, Reyes R, Johnson-Levonas AO, Sapre A, Donahue SR; Ezetimibe Study Group. A multicenter, randomized, double-blind, placebo-controlled, factorial design study to evaluate the lipid-altering efficacy and safety profile of the ezetimibe/simvastatin tablet compared with ezetimibe and simvastatin monotherapy in patients with primary hypercholesterolemia. Clin Ther 2004;26:1758-1773.
    • (2004) Clin Ther , vol.26 , pp. 1758-1773
    • Bays, H.E.1    Ose, L.2    Fraser, N.3    Tribble, D.L.4    Quinto, K.5    Reyes, R.6    Johnson-Levonas, A.O.7    Sapre, A.8    Donahue, S.R.9
  • 7
    • 33748303084 scopus 로고    scopus 로고
    • Treating to New Targets Investigators. Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: Analysis of the Treating to New Targets study
    • Deedwania P, Barter P, Carmena R, Fruchart JC, Grundy SM, Haffner S, Kastelein JJ, LaRosa JC, Schachner H, Shepherd J, Waters DD; Treating to New Targets Investigators. Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: analysis of the Treating to New Targets study. Lancet 2006;368:919-928.
    • (2006) Lancet , vol.368 , pp. 919-928
    • Deedwania, P.1    Barter, P.2    Carmena, R.3    Fruchart, J.C.4    Grundy, S.M.5    Haffner, S.6    Kastelein, J.J.7    LaRosa, J.C.8    Schachner, H.9    Shepherd, J.10    Waters, D.D.11
  • 8
    • 0034704893 scopus 로고    scopus 로고
    • C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    • Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-843.
    • (2000) N Engl J Med , vol.342 , pp. 836-843
    • Ridker, P.M.1    Hennekens, C.H.2    Buring, J.E.3    Rifai, N.4
  • 9
    • 0037078969 scopus 로고    scopus 로고
    • Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events
    • Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 2002;347:1557-1565.
    • (2002) N Engl J Med , vol.347 , pp. 1557-1565
    • Ridker, P.M.1    Rifai, N.2    Rose, L.3    Buring, J.E.4    Cook, N.R.5
  • 10
    • 0000590923 scopus 로고    scopus 로고
    • Production of C-reactive protein and risk of coronary events in stable and unstable angina European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group
    • Haverkate F, Thompson SG, Pyke SD, Gallimore JR, Pepys MB. Production of C-reactive protein and risk of coronary events in stable and unstable angina European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Lancet 1997;349:426-462.
    • (1997) Lancet , vol.349 , pp. 426-462
    • Haverkate, F.1    Thompson, S.G.2    Pyke, S.D.3    Gallimore, J.R.4    Pepys, M.B.5
  • 11
    • 0029812266 scopus 로고    scopus 로고
    • Serum Creactive protein concentration in acute myocardial infarction and its relationship to mortality during 24 months of follow-up in patients under thrombolytic treatment
    • Pietila KO, Harmoinen AP, Jokiniitty J, Pasternack AI. Serum Creactive protein concentration in acute myocardial infarction and its relationship to mortality during 24 months of follow-up in patients under thrombolytic treatment. Eur Heart J 1996;17:1345-1349.
    • (1996) Eur Heart J , vol.17 , pp. 1345-1349
    • Pietila, K.O.1    Harmoinen, A.P.2    Jokiniitty, J.3    Pasternack, A.I.4
  • 12
    • 0035799331 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein: Potential adjunct for global risk assessment in the primary prevention of cardiovascular disease
    • Ridker PM. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation 2001;103:1813-1818.
    • (2001) Circulation , vol.103 , pp. 1813-1818
    • Ridker, P.M.1
  • 13
    • 31344447948 scopus 로고    scopus 로고
    • The metabolic syndrome: Inflammation, diabetes mellitus, and cardiovascular disease
    • Haffner SM. The metabolic syndrome: inflammation, diabetes mellitus, and cardiovascular disease. Am J Cardiol 2006;97:3A-11A.
    • (2006) Am J Cardiol , vol.97
    • Haffner, S.M.1
  • 14
    • 14944370951 scopus 로고    scopus 로고
    • Effects of ezetimibe coadministered with simvastatin on C-reactive protein in a large cohort of hypercholesterolemic patients
    • Sager PT, Capece R, Lipka L, Strony J, Yang B, Suresh R, Mitchel Y, and Veltri E. Effects of ezetimibe coadministered with simvastatin on C-reactive protein in a large cohort of hypercholesterolemic patients. Atherosclerosis 2005;179:361-367.
    • (2005) Atherosclerosis , vol.179 , pp. 361-367
    • Sager, P.T.1    Capece, R.2    Lipka, L.3    Strony, J.4    Yang, B.5    Suresh, R.6    Mitchel, Y.7    Veltri, E.8
  • 15
  • 16
    • 16244402675 scopus 로고    scopus 로고
    • Ezetimibe Study Group. Long-term safety and, tolerability profiles and lipid-modifying efficacy of ezetimibe coadministered with ongoing simvastatin treatment: A multicenter, randomized, double-blind, placebo-controlled, 48-week extension study
    • Masana L, Mata P, Gagne C, Sirah W, Cho M, Johnson-Levonas AO, Meehan A, Troxell JK, Gumbiner B; Ezetimibe Study Group. Long-term safety and, tolerability profiles and lipid-modifying efficacy of ezetimibe coadministered with ongoing simvastatin treatment: A multicenter, randomized, double-blind, placebo-controlled, 48-week extension study. Clin Ther 2005;27:174-184.
    • (2005) Clin Ther , vol.27 , pp. 174-184
    • Masana, L.1    Mata, P.2    Gagne, C.3    Sirah, W.4    Cho, M.5    Johnson-Levonas, A.O.6    Meehan, A.7    Troxell, J.K.8    Gumbiner, B.9
  • 18
    • 11844291388 scopus 로고    scopus 로고
    • Ezetimibe Study Group. A multicenter, randomized, double-blind, placebo-controlled, factorial design study to evaluate the lipid-altering efficacy and safety profile of the ezetimibe/simvastatin tablet compared with ezetimibe and simvastatin monotherapy in patients with primary hypercholesterolemia
    • Bays HE, Ose L, Fraser N, Tribble DL, Quinto K, Reyes R, Johnson-Levonas AO, Sapre A, Donahue SR; Ezetimibe Study Group. A multicenter, randomized, double-blind, placebo-controlled, factorial design study to evaluate the lipid-altering efficacy and safety profile of the ezetimibe/simvastatin tablet compared with ezetimibe and simvastatin monotherapy in patients with primary hypercholesterolemia. Clin Ther 2004; 26:1758-1773.
    • (2004) Clin Ther , vol.26 , pp. 1758-1773
    • Bays, H.E.1    Ose, L.2    Fraser, N.3    Tribble, D.L.4    Quinto, K.5    Reyes, R.6    Johnson-Levonas, A.O.7    Sapre, A.8    Donahue, S.R.9
  • 20
    • 5444270779 scopus 로고    scopus 로고
    • Effects of ezetimibe added to on-going statin therapy on the lipid profile of hypercholesterolemic patients with diabetes mellitus or metabolic syndrome
    • Simons L, Tonkon M, Masana L, Maccubbin D, Shah A, Lee M, Gumbiner B. Effects of ezetimibe added to on-going statin therapy on the lipid profile of hypercholesterolemic patients with diabetes mellitus or metabolic syndrome. Curr Med Res Opin 2004;20:1437-1445.
    • (2004) Curr Med Res Opin , vol.20 , pp. 1437-1445
    • Simons, L.1    Tonkon, M.2    Masana, L.3    Maccubbin, D.4    Shah, A.5    Lee, M.6    Gumbiner, B.7
  • 21
    • 18244390229 scopus 로고    scopus 로고
    • A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: The ezetimibe add-on to statin for effectiveness (EASE) trial
    • Pearson TA, Denke MA, McBride PE, Battisti WP, Brady WE, Palmisano J. A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial. Mayo Clin Proc 2005;80:587-595.
    • (2005) Mayo Clin Proc , vol.80 , pp. 587-595
    • Pearson, T.A.1    Denke, M.A.2    McBride, P.E.3    Battisti, W.P.4    Brady, W.E.5    Palmisano, J.6
  • 22
    • 0035881018 scopus 로고    scopus 로고
    • Achieving and maintaining National Cholesterol Education Program low-density lipoprotein cholesterol goals with five statins
    • Andrews TC, Ballantyne CM, Hsia JA, Kramer JH. Achieving and maintaining National Cholesterol Education Program low-density lipoprotein cholesterol goals with five statins. Am J Med 2001;111:185-191.
    • (2001) Am J Med , vol.111 , pp. 185-191
    • Andrews, T.C.1    Ballantyne, C.M.2    Hsia, J.A.3    Kramer, J.H.4
  • 23
    • 0036895768 scopus 로고    scopus 로고
    • Combination therapy: Its rationale and the role of ezetimibe
    • Stone N. Combination therapy: its rationale and the role of ezetimibe. Eur Heart J 2002;4:J19-J22.
    • (2002) Eur Heart J , vol.4
    • Stone, N.1
  • 24
    • 0036895379 scopus 로고    scopus 로고
    • Evolving concepts and a new approach for management of hyperlipidemia
    • Ballantyne C. Evolving concepts and a new approach for management of hyperlipidemia. Eur Heart J 2002;4:J1-J3
    • (2002) Eur Heart J , vol.4
    • Ballantyne, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.