In vivo imaging of subcutaneous structures using functional photoacoustic microscopy

Nature Protocols

Volumn 2, Issue 4, 2007, Pages 797-804

  Zhang, Hao F ^a   Maslov, Konstantin ^a   Wang, Lihong V ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONFOCAL MICROSCOPY; FUNCTIONAL PHOTOACOUSTIC MICROSCOPY; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; IN VIVO STUDY; INFORMATION PROCESSING; LASER SAFETY; MICROSCOPIC ANATOMY; MICROSCOPY; MICROVASCULATURE; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; NUDE MOUSE; PHOTOACOUSTIC SPECTROSCOPY; PRACTICE GUIDELINE; PRIORITY JOURNAL; RAT; SAFETY; SIGNAL DETECTION; SPECTROSCOPY; SPRAGUE DAWLEY RAT; SUBCUTANEOUS TISSUE; ULTRASOUND TRANSDUCER; VOLUMETRY;

ANIMALS; LASERS; MICE; MICE, NUDE; MICROCIRCULATION; MICROSCOPY, ACOUSTIC; RATS; RATS, SPRAGUE-DAWLEY; SUBCUTANEOUS TISSUE;

ANIMALIA;

EID: 34247340041     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2007.108     Document Type: Article

References (26)

1. Xu, M. & Wang, L.V. Photoacoustic imaging in biomedicine. Rev. Sci. Instrum. 77, 041101 (2006).
2. Wang, X. et al. Noninvasive laser-induced photoacoustic tomography for structural and functional imaging of the brain in vivo. Nat Biotechnol. 21, 803-806 (2003).
3. Hoelen, C.G.A., de Mul, F.F.M., Pongers, R. & Dekker, A. Three-dimensional photoacoustic imaging of blood vessels in tissue. Opt. Lett. 23, 648-650 (1998).
4. Oraevsky, A.A. & Karabutov, A.A. Optoacoustic Tomography, in Biomedical Photonics Handbook, Vol. PM125 (ed. Vo-Dinh, T.) (CRC Press, Boca Raton, Florida, 2003).
5. Kruger, R.A., Liu, P., Fang, Y.R. & Appledom, C.R. Photoacoustic ultrasound (PAUS) - reconstruction tomography. Med. Phys. 22 1605-1609 (1995).
6. Bell, A.G. On the production and reproduction of sound by light. Am. J. Sci. 20, 305-324 (1880).
7. Diebold, G.J., Khan, M.I. & Park, S.M. Photoacoustic "signature" of particulate matter: Optical production of acoustic monopole radiation. Science 250, 101-104 (1990).
8. Tam, A.C. Applications of photoacoustic sensing techniques. Rev. Mod. Phys. 58, 381-431 (1986).
9. Oleary, M.A., Boas, D.A., Chance, B. & Yodh, A.G. Experimental images of heterogeneous turbid media by frequency-domain diffuse-photon tomography. Opt. Lett. 20, 426-428 (1995).
10. Boas, D.A. et al. Imaging the body with diffuse optical tomography. IEEE Signal Processing Mag. 18, 57-75 (2001).
11. Duck, F.A. Physical Properties of Tissue (Academy Press, London, 1990).
12. Maslov, K., Stoica, G. & Wang, L.V. In vivo dark-field reflection-mode photoacoustic microscopy. Opt. Lett. 30, 625-627 (2005).
13. Zhang, H.F., Maslov, K., Stoica, G. & Wang, L.V. Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging. Nat. Biotechnol. 24, 848-851 (2006).
14. Zhang, H.F., Maslov, K., Li, M.-L., Stoica, G. & Wang, L.V. In vivo volumetric imaging of subcutaneous microvasculature by photoacoustic microscopy. Opt. Express. 14, 9317-9323 (2006).
15. Zhang, H.F., Maslov, K., Sivaramakrishnan, M., Stoica, G. & Wang, L.V. Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy. Appl. Phys. Lett. 90 052901 (2007).
16. Oh, J.-T., Li, M.-L., Zhang, H.F., Maslov, K., Stoica, G. & Wang, L.V. Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy. J. Biomed. Opt. 11 034032 (2006).
17. Zhang, H.F., Maslov, K., Stoica, G. & Wang, L.V. Imaging acute thermal burns by photoacoustic microscopy. J. Biomed. Opt. 11, 054033 (2006).
18. Li, L., Zemp, R.J., Lungu, G., Stoica, G. & Wang, L.V. Imaging of gene expression in vivo with photoacoustic tomography. Proc. SPIE 6086, 62-67 (2006).
19. Maslov, K., Sivaramakrishnan, M., Zhang, H.F., Stoica, G. & Wang, L.V. Technical considerations in quantitative blood oxygenation measurement using photoacoustic microscopy in vivo. Proc. SPIE 6086, 215-225 (2006).
20. Briggs, G.A.D. Acoustic Microscopy (Clarendon, Oxford, 1992).
21. Laser Institute of America, American National Standard for Safe Use of Lasers ANSI Z136.1-2000, (American National Standards Institute Inc., New York, NY, 2000).
22. Li, M.-L., Zhang, H.F., Maslov, K., Stoica, G. & Wang, L.V. Improved in vivo photoacoustic microscopy based on a virtual-detector concept. Opt. Lett. 31, 474-476 (2006).
23. Brown, D.G. & Riederer, S.J. Contrast-to-noise ratio in maximum intensity projection images. Magn. Reson. Med. 23, 130-137 (1992).
24. Anderson, C.M., Saloner, D., Tsuruda, J.S., Shapeero, L.G. & Lee, R.E. Artifacts in maximum-intensity-projection display of MR angiograms. Am. J. Roentgenol. 154, 623-629 (1990).
25. Laufer, J., Deply, D., Elwell, C. & Beard, P. Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: Application to the measurement of blood oxygenation and haemoglobin concentration. Phys. Med. Biol. 52 141-168 (2007).
26. Wilson, B.C. & Jacques, S.L. Optical reflectance and transmittance of tissues: Principles and applications. IEEE J. Quant. Electron. 26, 2186-2199 (1990).