Gene therapy for Parkinson's disease

Brain and Nerve

Volumn 59, Issue 4, 2007, Pages 425-430

  Muramatsu, Shin Ichi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Adeno associated virus; Dopamine; Gene therapy; Parkinson's disease

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOVIRUS VECTOR; AROMATIC LEVO AMINO ACID DECARBOXYLASE; DOPAMINE; GLUTAMATE DECARBOXYLASE; LEVODOPA; NEURTURIN; RECOMBINANT ADENOVIRUS VECTOR; UNCLASSIFIED DRUG;

ARTICLE; BRAIN DEPTH STIMULATION; CLINICAL TRIAL; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HUMAN; NEUROTRANSMISSION; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; PUTAMEN; SUBTHALAMIC NUCLEUS;

GENE THERAPY; HUMANS; PARKINSON DISEASE;

EID: 34247279907     PISSN: 00068969     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Roth BL: Drugs and valvular heart disease. N Engl J Med 356: 6-9, 2007
2. Muramatsu S, Tsukada H, Nakano I, Ozawa K: Gene therapy for Parkinson's disease using recombinant adeno-associated viral vectors. Exp Opin Biol Ther 5: 663 671, 2005
3. Bankiewicz KS, Forsayeth J, Eberling JL, Sanchezpernaute R, Pivirotto P, et al: Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC. Mol Ther 14: 564-570, 2006
4. Wu Z, Asokan A, Samulski RJ: Adeno-associated virus serotypes: vector toolkit for human gene therapy. Mol Ther 14: 316-327, 2006
5. Manno CS, Pierce GF, Arruda VR, Glader B, Ragni M, et al: Successful transduction of liver in hemophilia by AAV-factor IX and limitations imposed by the host immune response. Nat Med 12: 342-347, 2006
6. Bankiewicz KS, Eberling JL, Kohutnicka M, Jagust W, Pivirotto P, et al: Convection-enhanced delivery of AAV vector in parkinsonian monkeys; In vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach. Exp Neurol 164: 2-14, 2000
7. th International Congress, Kyoto, October 30, 2006
8. Dass B, Olanow CW, Kordower JH: Gene transfer of trophic factors and stem cell grafting as treatments for Parkinson's disease. Neurology 66: S89-S103. 2006
9. rd, et al: Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys. Ann Neurol 60: 706-715, 2006
10. Wang LJ, Muramatsu S, Lu YY, Ikeguchi K, Fujimoto K, et al: Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease. Gene Ther 9: 381-389, 2002
11. th International Congress, Kyoto, November 2, 2006
12. During MJ, Kaplitt MG, Stern MB, Eidelberg D: Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation. Hum Gene Ther 12: 1589-1591, 2001
13. Luo J, Kaplitt MG, Fitzscimons HL, Zuzga DS, Liu Y, et al: Subthalamic GAD gene therapy in a Parkinson's disease rat model. Science 298: 425-429, 2002
14. Plaha P, Ben-Shlomo Y, Patel NK, Gill SS: Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism. Brain 129: 1732-1747, 2006
15. During MJ, Feigin A, Eidelberg D, Fitzsimons H, Bland R, et al: Subthalamic GAD gene transfer-improves brain metabolism associated with clinical recovery in Parkinson's disease. Society for Neuroscience Annual Meeting, Atlanta, October 17, 2006
16. Emborg ME, Carbon M, Holden JE, During MJ, Ma Y, et al: Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism. J Cereb Blood Flow Metab 2006, Jul 12; [Epub ahead of print]
17. Muramatsu S, Fujimoto K, Ikeguchi K, Shizuma N, Kawasaki K, et al: Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes. Hum Gene Ther 13: 345-354, 2002
18. Li XG, Okada T, Kodera M, Nara Y, Takino N, et al: Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease. Mol Ther 13: 160-166, 2006
19. Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, et al: Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proc Natl Acad Sci U S A 101: 17510-17515, 2004
20. Yamada M, Mizuno Y, Mochizuki H: Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease. Hum Gene Ther 16: 262-270, 2005