Rift Valley fever virus lacking NSm proteins retains high virulence in vivo and may provide a model of human delayed onset neurologic disease

Virology

Volumn 362, Issue 1, 2007, Pages 10-15

  Bird, Brian H ^a,b   Albariño, César G ^a   Nichol, Stuart T ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute hepatic disease; Bunyaviridae; Delayed neurologic disease; Hemorrhagic fever; Molecular pathogenesis; NSm protein; Pathogenesis; Phlebovirus; Rat model; Recombinant virus; Reverse genetics; Rift Valley fever virus; Viral virulence factors

Indexed keywords

PROTEIN NSM; PROTEIN NSS; UNCLASSIFIED DRUG; VIRULENCE FACTOR; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENETIC ANALYSIS; IN VIVO STUDY; LETHARGY; LIVER DISEASE; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RIFT VALLEY FEVER BUNYAVIRUS; TREMOR; VIRUS RECOMBINANT; VIRUS STRAIN; VIRUS VIRULENCE;

ANIMALS; ATAXIA; DISEASE MODELS, ANIMAL; ENCEPHALITIS, VIRAL; FEMALE; GENE DELETION; HEPATITIS, VIRAL, ANIMAL; LETHARGY; RATS; RATS, INBRED WF; RIFT VALLEY FEVER; RIFT VALLEY FEVER VIRUS; SURVIVAL ANALYSIS; TREMOR; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE;

ANIMALIA; BUNYAVIRIDAE; PHLEBOVIRUS; RATTUS; RIFT VALLEY FEVER VIRUS;

EID: 34247277649     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2007.01.046     Document Type: Article

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