Effect of two work practice changes on the microbial contamination rates of pharmacy-compounded sterile preparations

American Journal of Health-System Pharmacy

Volumn 64, Issue 8, 2007, Pages 837-841

  Trissel, Lawrence A ^a   Gentempo, Joseph A ^b   Saenz, Lisa M ^b   Woodard, Monica Y ^b   Angeles, Carol H ^b  

^a TriPharma Research   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Alcohols, isopropyl; Compounding; Contamination; Disinfectants; Gloves; Pharmacy; Sterile products

Indexed keywords

2 PROPANOL;

ARTICLE; ASEPSIS; CLINICAL PHARMACOLOGY; DISINFECTION; DRUG CONTAMINATION; DRUG FORMULATION; HEALTH CARE QUALITY; HOSPITAL PHARMACY; MICROBIAL CONTAMINATION; PHARMACIST; PRIORITY JOURNAL; PROTECTIVE CLOTHING; STAFF TRAINING;

EID: 34247266557     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.2146/060199     Document Type: Article

References (15)

1. Pharmaceutical compounding - sterile preparations. Pharmacopeial Forum. 2003; 29:750-809.
2. San Francisco Chronicle. Who is mixing your drugs? Bad medicine: pharmacy mix-ups a recipe for misery. Some drug-stores operate with very little oversight. http://sfgate.com/cgi-bin/article.cgi?f=/c/a/2002/06/23/MN12273. DTL&hw=bod+medicine&sn=006&sc=826 (accessed 2007 Jan 28).
3. North Carolina Department of Health and Human Services. Painkiller suspected in fourth N.C. meningitis case. www.dhhs.state.nc.us/pressrel/10-18- 02.htm (accessed 2002 Nov 22).
4. MMWR Weekly. Exophiala infection from contaminated injectable steroids prepared by a compounding pharmacy - United States, July - November 2002. www.cdc.gov/mmwr/preview/mmwrhtml/mm5149al.htm (accessed 2002 Dec 16).
5. The United States pharmacopeia, 25th rev., and The national formulary, 20th ed. Rockville, MD: United States Pharmacopeial Convention; 2002:2234-47.
6. ASHP guidelines on quality assurance for pharmacy-prepared sterile products. Am J Health-Syst Pharm. 2000; 57:150-69.
7. Trissel LA, Ogundele AB, Ingram DS et al. Using a media fill simulation to establish a benchmark microbiological contamination rate for low risk level compounding. Am J Health-Syst Pharm. 2003; 60:1853-5.
8. Trissel LA, Gentempo JA, Anderson RW et al. Using a media fill simulation to evaluate the microbial contamination rate for USP medium risk level compounding. Am J Health-Syst Pharm. 2005; 62:285-8.
9. Huey WY, Newton DW, Augustine SC et al. Microbial contamination potential of sterile disposable plastic syringes. Am J Hosp Pharm. 1985; 42:102-5.
10. Mitrano FP, Baptista RJ, Newton DW et al. Microbial contamination potential of solutions in prefilled disposable syringes used with a syringe pump. Am J Hosp Pharm. 1986; 43:78-80.
11. The United States pharmacopeia, 29th rev., and The national formulary, 24th ed. Rockville, MD: United States Pharmacopeial Convention; 2006:2735-51.
12. Slaughter RL, Edwards DJ, eds. Evaluating drug literature - a statistical approach. New York: McGraw-Hill Medical Publishing Division; 2001.
13. Gaddis GM, Gaddis ML. Introduction to biostatistics: part 5. Statistical inference techniques for hypothesis testing with nonparametric data. Ann Emerg Med. 1990; 20:1054-9.
14. Gaddis GM, Gaddis ML. Introduction to biostatistics: part 4. Statistical inference techniques in hypothesis testing. Ann Emerg Med. 1990; 19:820-5.
15. Gaddis GM, Gaddis ML. Introduction to biostatistics: part 3. Sensitivity, specificity, predictive value and hypothesis testing. Ann Emerg Med. 1990; 19:591-7.