Bmi-1 over-expression plays a secondary role in chronic myeloid leukemia transformation

Leukemia and Lymphoma

Volumn 48, Issue 4, 2007, Pages 793-801

  Merkerova, Michaela ^a   Bruchova, Hana ^a   Kracmarova, Alzbeta ^a   Klamova, Hana ^a   Brdicka, Radim ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION   (Czech Republic)

Author keywords

Bmi 1; CML; Expression arrays; Proliferation; siRNA

Indexed keywords

BINDING PROTEIN; BRCA2 PROTEIN; CASPASE 8; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLIN DEPENDENT KINASE; GENE PRODUCT; HEPATOMA DERIVED GROWTH FACTOR; NOTCH4 RECEPTOR; ONCOPROTEIN; POLO LIKE KINASE 1; POTEIN BMI 1; PROTEIN BAD; PROTEIN P16INK4; PROTEIN P16INK4A; RBQ1 RETINOBLASTOMA BINDING PROTEIN; RETINOBLASTOMA BINDING PROTEIN 4; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F3; TUMOR NECROSIS FACTOR RECEPTOR 1 ASSOCIATED DEATH DOMAIN PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT8B PROTEIN;

ADULT; APOPTOSIS; ARTICLE; CELL GROWTH; CELL TRANSFORMATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GENE FUNCTION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MALE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; CELL PROLIFERATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, LEUKEMIC; GENE SILENCING; HUMANS; K562 CELLS; LEUKEMIA, MYELOID, CHRONIC; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING;

EID: 34247236708     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190601186002     Document Type: Article

References (28)

1. Jacobs, J. J., Kieboom, K., Marino, S., DePinho, R. A. and van Lohuizen, M. (1999) The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature, 397, pp. 164-168.
2. Jacobs, J. J., Scheijen, B., Voncken, J. W., Kieboom, K., Berns, A. and van Lohuizen, M. (1999) Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev, 13, pp. 2678-2690.
3. van Kemenade, F. J., Raaphorst, F. M., Blokzijl, T., Fieret, E., Hamer, K. M. and Satijn, D. P. (2001) Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. Blood, 97, pp. 3896-3901.
4. Vonlanthen, S., Heighway, J., Altermatt, H. J., Gugger, M., Kappeler, A. and Borner, M. M. (2001) The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression. Br J Cancer, 84, pp. 1372-1376.
5. Bea, S., Tort, F., Pinyol, M., Puig, X., Hernandez, L. and Hernandez, S. (2001) BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas. Cancer Res, 61, pp. 2409-2412.
6. Lessard, J. and Sauvageau, G. (2003) Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature, 423, pp. 255-260.
7. Park, I. K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M. and Weissman, I. L. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature, 423, pp. 302-305.
8. Shah, N. P., Tran, C., Lee, F. Y., Chen, P., Norris, D. and Sawyers, C. L. (2004) Overriding imatinib resistance with a novel ABL kinase inhibitor. Science, 305, pp. 399-401.
9. Weisberg, E., Manley, P. W., Breitenstein, W., Bruggen, J., Cowan-Jacob, S. W. and Ray, A. (2005) Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell, 7, pp. 129-141.
10. Gumireddy, K., Baker, S. J., Cosenza, S. C., John, P., Kang, A. D. and Robell, K. A. (2005) A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance. Proc Natl Acad Sci USA, 102, pp. 1992-1997.
11. Wolff, N. C., Veach, D. R., Tong, W. P., Bornmann, W. G., Clarkson, B. and Ilaria Jr, R. L. (2005) PD166326, a novel tyrosine kinase inhibitor, has greater antileukemic activity than imatinib mesylate in a murine model of chronic myeloid leukemia. Blood, 105, pp. 3995-4003.
12. Scherr, M., Battmer, K., Winkler, T., Heidenreich, O., Ganser, A. and Eder, M. (2003) Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood, 101, pp. 1566-1568.
13. Merkerova, M., Bruchova, H. and Brdicka, R. (2005) Specific silencing of PCNA gene expression in leukemic cell lines using siRNA. Cas Lek Cesk, 144, pp. 472-475.
14. Chomczynsky, P. and Sacchi, N. (1987) Single step method of RNA isolation by acid guanidin-isothiocyanate-phenol-chloroform extraction. Anal Biochem, 162, pp. 156-159.
15. Molofsky, A. V., Pardal, R., Iwashita, T., Park, I. K., Clarke, M. F. and Morrison, S. J. (2003) Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature, 425, pp. 962-967.
16. Brisson, M., Nguyen, T., Vogt, A., Yalowich, J., Giorgianni, A. and Tobi, D. (2004) Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase. Mol Pharmacol, 66, pp. 824-833.
17. Gasparotto, D., Maestro, R., Piccinin, S., Vukosavljevic, T., Barzan, L. and Sulfaro, S. (1997) Overexpression of CDC25A and CDC25B in head and neck cancers. Cancer Res, 57, pp. 2366-2368.
18. Liu, X. and Erikson, R. L. (2003) Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells. Proc Natl Acad Sci USA, 100, pp. 5789-5794.
19. Zhu, Y. Y., Shi, J. M., Sun, J., Lan, J. P., Lai, X. Y. and Li, J. Y. (2004) Expression of Pin1 in malignant hematopoietic cells and its relation with cell cycle. Zhejiang Da Xue Xue Bao Yi Xue Ban, 33, pp. 500-503.
20. Ranger, A. M., Zha, J., Harada, H., Datta, S. R., Danial, N. N. and Gilmore, A. P. (2003) Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci USA, 100, pp. 9324-9329.
21. Wu, G. S., Burns, T. F., McDonald III, E. R., Jiang, W., Meng, R. and Krantz, I. D. (1997) KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet, 17, pp. 141-143.
22. Paulson, Q. X., McArthur, M. J. and Johnson, D. G. (2006) E2F3a stimulates proliferation, p53-independent apoptosis and carcinogenesis in a transgenic mouse model. Cell Cycle, 5, pp. 184-190.
23. Nicolas, E., Morales, V., Magnaghi-Jaulin, L., Harel-Bellan, A., Richard-Foy, H. and Trouche, D. (2000) RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein. J Biol Chem, 275, pp. 9797-9804.
24. Huang, P., Feng, L., Oldham, E. A., Keating, M. J. and Plunkett, W. (2000) Superoxide dismutase as a target for the selective killing of cancer cells. Nature, 407, pp. 390-395.
25. Davies, A. A., Masson, J. Y., McIlwraith, M. J., Stasiak, A. Z., Stasiak, A. and Venkitaraman, A. R. (2001) Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol Cell, 7, pp. 273-282.
26. Liu, S., Dontu, G. and Wicha, M. S. (2005) Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res, 7, pp. 86-95.
27. Menard, S., Tagliabue, E. and Colnaghi, M. I. (1998) The 67 kDa laminin receptor as a prognostic factor in human cancer. Breast Cancer Res Treat, 52, pp. 137-145.
28. Hirohashi, S. and Kanai, Y. (2003) Cell adhesion system and human cancer morphogenesis. Cancer Sci, 94, pp. 575-581.