Suppression of catechol-O-methyltransferase activity through blunting of α2-adrenoceptor can explain hypertension in dahl salt-sensitive rats

Hypertension Research

Volumn 30, Issue 3, 2007, Pages 269-278

  Hirano, Yoko ^a   Tsunoda, Makoto ^a   Shimosawa, Tatsuo ^b   Matsui, Hiromitsu ^b   Fujita, Toshiro ^b   Funatsu, Takashi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Catechol O methyltransferase; Catecholamines; Dahl; Norepinephrine; Pithed rat

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CATECHOL METHYLTRANSFERASE; CATECHOLAMINE; DOPAMINE; HYDRALAZINE; NORADRENALIN; POSTSYNAPTIC RECEPTOR; PRESYNAPTIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; DOPAMINE URINE LEVEL; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; HYPERTENSION; IN VITRO STUDY; KIDNEY; LIVER; MALE; NATRIURESIS; NONHUMAN; NORADRENALIN RELEASE; NORADRENALIN URINE LEVEL; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALT INTAKE; SALT LOADING; SIGNAL TRANSDUCTION; SPINAL ANIMAL;

ANIMALS; BLOOD PRESSURE; CATECHOL O-METHYLTRANSFERASE; DISEASE MODELS, ANIMAL; DOPAMINE; GENE EXPRESSION REGULATION; HYPERTENSION; MALE; NOREPINEPHRINE; RATS; RATS, INBRED DAHL; RECEPTORS, ADRENERGIC, ALPHA-2; RNA, MESSENGER; SODIUM CHLORIDE;

EID: 34247228662     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1291/hypres.30.269     Document Type: Article

References (29)

1. Dahl LK, Heine M, Tassinari L: Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion. Nature 1962; 194: 480-482.
2. Saavedra JM, Carmine RD, Mccarty R, Guicheney P, Weise V, Iwai J: Increased adrenal catecholamines in salt-sensitive genetically hypertensive Dahl rats. Am J Physiol 1983; 245: H762-H766.
3. 2-adrenoceptor activity in Dahl salt-sensitive rats by dietary sodium changes. Meth Find Exp Clin Pharmacol 1998; 20: 755-760.
4. Mccarty R, Saavedra JM: Plasma catecholamines in salt-sensitive hypertensive (Dahl) rats. Physiol Behav 1982; 28: 1083-1088.
5. Saruta T, Kumagai H: The sympathetic nervous system in hypertension and renal diseases. Curr Opin Nephrol Hypertens 1996; 5: 72-79.
6. Aperia AC: Internal dopamine: a key signal in the interactive regulation of sodium metabolism. Annu Rev Physiol 2000; 62: 621-647.
7. Carey RM: Renal dopamine system. Paracrine regulator of sodium homeostasis and blood pressure (Theodore Cooper Memorial Lecture). Hypertension 2001; 38: 297-302.
8. +-ATPase activity is lacking in Dahl salt-sensitive rats. Hypertension 1993; 21: 767-771.
9. 1 receptor in the prehypertensive Dahl salt-sensitive rat. Exp Nephrol 1995; 3: 15-22.
10. Männistö PT, Kaakkola S: Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 1999; 51: 593-628.
11. Tsunoda M, Tenhunen J, Tilgmann C, Arai H, Imai K: Reduced membrane-bound catechol-0-methyltransferase in the liver of spontaneously hypertensive rats. Hypertens Res 2003; 26: 923-927.
12. Odlind C, Göransson V, Reenilä I, Hansell P: Regulation of dopamine-induced natriuresis by the dopamine-metabolizing enzyme catechol-O-methyltransferase. Exp Nephrol 1999; 7: 314-322.
13. +-ATPase. Kidney Int 1997; 52: 742-747.
14. Helkamaa T, Männistö PT, Rauhala P, et al: Resistance to salt-induced hypertension in catechol-O-methyltransferasegene-disrupted mice. J Hypertens 2003; 21: 2365-2374.
15. Hirano Y, Tsunoda M, Funatsu T, lmai K: Rapid assay for catechol-O-methyltransferase activity by high-performance liquid chromatography-fluorescence detection. J Chromatogr B 2005; 819: 41-46.
16. Bradford MM: A rapid method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
17. Lineweaver H, Burk D: The determination of enzyme dissociation constants. J Am Chem Soc 1934; 56: 658-666.
18. Takezawa K, Tsunoda M, Watanabe N, Imai K: An automatic analyzer for catecholarnines and their 3-O-methyl metabolites using a micro coulometric flow cell as a post-column reactor for fluorogenic reaction. Anal Chem 2000; 72: 4009-4014.
19. Tenhunen J, Salminen M, Lundstrbrn K, Kiviluoto T, Savolainen R, Ulmanen I: Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters. Eur J Biochem 1994; 223: 1049-1059.
20. Tsunoda M, Takezawa K, Santa T, Imai K: Simultaneous automatic determination of catecholarnines and their 3-O-methyl metabolites in rat plasma by high-performance liquid chromatography using peroxyoxalate chemiluminescence reaction. Anal Biochem 1999; 269: 386-392.
21. Kawai J, Ando K, Shimosawa T, Harri K, Fujita T: Regional hemodynamic effects of adrenomedullin in Wistar rats: a comparison with calcitonin gene-related peptide. Hypertens Res 2002; 25: 441-446.
22. Shimosawa T, Fujita T: Hypotensive effect of a newly identified peptide, proadrenomedullin N-terminal 20 peptide. Hypertension 1996; 28: 325-329.
23. Shimosawa T, Ando K, Fujita T: A newly identified peptide, proadrenomedullin N-terminal 20 peptide, induces hypotensive action via pertussis toxin-sensitive mechanisms. Hypertension 1997; 30: 1009-1014.
24. Doxey JC, Everitt J: Inhibitory effects of clonidine on responses to sympathetic nerve stimulation in the pithed rat. Br J Pharmacol 1977; 61: 559-566.
25. 2-adrenoceptors: an investigation of the effects of clonidine in the pithed rat. Br J Pharmacol 1980; 68: 225-234.
26. Tsunoda M, Takezawa K, Masuda M, Imai K: Rat liver and kidney catechol-O-methyltransferase activity measured by high-performance liquid chromatography with fluorescence detection. Biomed Chromatogr 2002; 16: 536-541.
27. Kost DP, DeFrances MC, Lee C-R, Michalopoulos GK: Patterns of alpha-1-adrenergic receptor expression in regenerating and neoplastic hepatic tissue. Pathobiology 1992; 60: 303-308.
28. Cayla C, Schaak S, Roquelaine C, Gales C, Quinchon F, Paris H: Homologous regulation of the α2C-adrenoceptor subtype in human hepatocarcinoma, HepG2. Br J Pharmacol 1999; 126: 69-78.
29. Schaak S, Cayla C, Blaise R, Quinchon F, Paris H: HepG2 and SK-N-MC: two human models to study alpha-2 adrenergic receptous of the alpha-2C subtype. J Pharmacol Exp Ther 1997; 281: 983-991.